Compressive Sensing DNA Microarrays

Compressive sensing microarrays (CSMs) are DNA-based sensors that operate using group testing and compressive sensing (CS) principles. In contrast to conventional DNA microarrays, in which each genetic sensor is designed to respond to a single target, in a CSM, each sensor responds to a set of targets. We study the problem of designing CSMs that simultaneously account for both the constraints from CS theory and the biochemistry of probe-target DNA hybridization. An appropriate cross-hybridization model is proposed for CSMs, and several methods are developed for probe design and CS signal recovery based on the new model. Lab experiments suggest that in order to achieve accurate hybridization profiling, consensus probe sequences are required to have sequence homology of at least 80% with all targets to be detected. Furthermore, out-of-equilibrium datasets are usually as accurate as those obtained from equilibrium conditions. Consequently, one can use CSMs in applications in which only short hybridization times are allowed

True colour retrieval from multiple illuminant scene’s image

This paper presents an algorithm to retrieve the true colour of an image captured under multiple illuminant. The proposed method uses a histogram analysis and K-means++ clustering technique to split the input image into a number of segments. It then determines normalised average absolute difference (NAAD) for each resulting segment’s colour component. If the NAAD of the segment’s component is greater than an empirically determined threshold. It assumes that the segment does not represent a uniform colour area, hence the segment’s colour component is selected to be used for image colour constancy adjustment. The initial colour balancing factor for each chosen segment’s component is calculated using the Minkowski norm based on the principal that the average values of image colour components are achromatic. It finally calculates colour constancy adjustment factors for each image pixel by fusing the initial colour constancy factors of the chosen segments weighted by the normalised Euclidian distances of the pixel from the centroids of the selected segments. Experimental results using benchmark single and multiple illuminant image datasets, show that the proposed method’s images subjectively exhibit highest colour constancy in the presence of multiple illuminant and also when image contains uniform colour areas

Colour Constancy For Non‐Uniform Illuminant using Image Textures

Colour constancy (CC) is the ability to perceive the true colour of the scene on its image regardless of the scene’s illuminant changes. Colour constancy is a significant part of the digital image processing pipeline, more precisely, where true colour of the object is needed. Most existing CC algorithms assume a uniform illuminant across the whole scene of the image, which is not always the case. Hence, their performance is influenced by the presence of multiple light sources. This paper presents a colour constancy algorithm using image texture for uniform/non-uniformly lit scene images. The propose algorithm applies the K-means algorithm to segment the input image based on its different colour feature. Each segment’s texture is then extracted using the Entropy analysis algorithm. The colour information of the texture pixels is then used to calculate initial colour constancy adjustment factor for each segment. Finally, the colour constancy adjustment factors for each pixel within the image is determined by fusing the colour constancy of all segment regulated by the Euclidian distance of each pixel from the centre of the segments. Experimental results on both single and multiple illuminant image datasets show that the proposed algorithm outperforms the existing state of the art colour constancy algorithms, particularly when the images lit by multiple light sources

π+π+\pi^+\pi^+ and π+π−\pi^+\pi^- colliding in noncommutative space

By studying the scattering process of scalar particle pion on the noncommutative scalar quantum electrodynamics, the non-commutative amendment of differential scattering cross-section is found, which is dependent of polar-angle and the results are significantly different from that in the commutative scalar quantum electrodynamics, particularly when $\cos\theta\sim \pm 1$. The non-commutativity of space is expected to be explored at around $\Lambda_{NC}\sim$TeV.Comment: Latex, 12 page

Factors influencing farmers' participation in water management: a community development perspective

Participation is believed to a systematic involvement of the significant number of people, in diverse activities to manage their own problems, carrying the concept of togetherness, which enhance the advantages. It always oscillates and depends on the background in which it occurs. Farmers' participation is critical to improve on-farm water management and crop productivity. The study was conducted to identify the factors involved in the fluctuation of participation. This paper reports the results, in which, farmer participation through planning, implementation, monitoring and evaluation of water-user associations were measured, and it was linked to various socioeconomic, demographic, and farm and irrigation characteristics. Multiple linear regression analysis reveals that the participation was positively influenced by age, education, residential locality, house type, lack of on-farm facilities, underground water use for irrigation purpose and location of watercourses on the canal network. However, residential locality and on-farm facilities have significantly negative relationships with the dependent variable in Sindh province of Pakistan

Renormalization Group Equations and the Lifshitz Point In Noncommutative Landau-Ginsburg Theory

A one-loop renormalization group (RG) analysis is performed for noncommutative Landau-Ginsburg theory in an arbitrary dimension. We adopt a modern version of the Wilsonian RG approach, in which a shell integration in momentum space bypasses the potential IR singularities due to UV-IR mixing. The momentum-dependent trigonometric factors in interaction vertices, characteristic of noncommutative geometry, are marginal under RG transformations, and their marginality is preserved at one loop. A negative $\Theta$-dependent anomalous dimension is discovered as a novel effect of the UV-IR mixing. We also found a noncommutative Wilson-Fisher (NCWF) fixed point in less than four dimensions. At large noncommutativity, a momentum space instability is induced by quantum fluctuations, and a consequential first-order phase transition is identified together with a Lifshitz point in the phase diagram. In the vicinity of the Lifshitz point, we introduce two critical exponents $\nu_m$ and $\beta_k$, whose values are determined to be 1/4 and 1/2, respectively, at mean-field level.Comment: 37 pages, 4 figure

Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal Dystrophies in 144 Consanguineous Pakistani Families.

PurposeThe Pakistan Punjab population has been a rich source for identifying genes causing or contributing to autosomal recessive retinal degenerations (arRD). This study was carried out to delineate the genetic architecture of arRD in the Pakistani population.MethodsThe genetic origin of arRD in a total of 144 families selected only for having consanguineous marriages and multiple members affected with arRD was examined. Of these, causative mutations had been identified in 62 families while only the locus had been identified for an additional 15. The remaining 67 families were subjected to homozygosity exclusion mapping by screening of closely flanking microsatellite markers at 180 known candidate genes/loci followed by sequencing of the candidate gene for pathogenic changes.ResultsOf these 67 families subjected to homozygosity mapping, 38 showed homozygosity for at least one of the 180 regions, and sequencing of the corresponding genes showed homozygous cosegregating mutations in 27 families. Overall, mutations were detected in approximately 61.8 % (89/144) of arRD families tested, with another 10.4% (15/144) being mapped to a locus but without a gene identified.ConclusionsThese results suggest the involvement of unmapped novel genes in the remaining 27.8% (40/144) of families. In addition, this study demonstrates that homozygosity mapping remains a powerful tool for identifying the genetic defect underlying genetically heterogeneous arRD disorders in consanguineous marriages for both research and clinical applications

Description and process evaluation of pharmacists’ interventions in a pharmacist-led information technology-enabled multicentre cluster randomised controlled trial for reducing medication errors in general practice (PINCER trial)

Objective To undertake a process evaluation of pharmacists' recommendations arising in the context of a complex IT-enabled pharmacist-delivered randomised controlled trial (PINCER trial) to reduce the risk of hazardous medicines management in general practices. Methods PINCER pharmacists manually recorded patients’ demographics, details of interventions recommended, actions undertaken by practice staff and time taken to manage individual cases of hazardous medicines management. Data were coded and double entered into SPSS v15, and then summarised using percentages for categorical data (with 95% CI) and, as appropriate, means (SD) or medians (IQR) for continuous data. Key findings Pharmacists spent a median of 20 minutes (IQR 10, 30) reviewing medical records, recommending interventions and completing actions in each case of hazardous medicines management. Pharmacists judged 72% (95%CI 70, 74) (1463/2026) of cases of hazardous medicines management to be clinically relevant. Pharmacists recommended 2105 interventions in 74% (95%CI 73, 76) (1516/2038) of cases and 1685 actions were taken in 61% (95%CI 59, 63) (1246/2038) of cases; 66% (95%CI 64, 68) (1383/2105) of interventions recommended by pharmacists were completed and 5% (95%CI 4, 6) (104/2105) of recommendations were accepted by general practitioners (GPs), but not completed at the end of the pharmacists’ placement; the remaining recommendations were rejected or considered not relevant by GPs. Conclusions The outcome measures were used to target pharmacist activity in general practice towards patients at risk from hazardous medicines management. Recommendations from trained PINCER pharmacists were found to be broadly acceptable to GPs and led to ameliorative action in the majority of cases. It seems likely that the approach used by the PINCER pharmacists could be employed by other practice pharmacists following appropriate training