Changing ideas of bodily cleanliness

The modern bathroom reflects Western ideas on the handling of bodily wastes, and consequently ideas of cleanliness. Taking a historical study as the point of departure, the purpose of this paper is to understand the extent to which the idea of cleanliness influences the possibility of converting the water closet to a more sustainable technology. An examination of historical changes demonstrates that our present ideas on cleanliness are distinct in their own way. It also demonstrates that our present ideas of cleanliness represent a drawing together of several loose ends, development towards which having been incoherent. Great variation has been apparent in practices surrounding, and the social importance of, cleanliness. People have lived in different ways and have had different ideas about how to behave. The Roman culture thought of bathing and relieving oneself as social duties. In the Middle Ages, uncleanliness ruled the day as people had a very natural and relaxed attitude to bodily waste. Following the urbanisation process, cleanliness was thought of as a step towards progress and a sanitational cure for epidemics in the cities. In more recent times, cleanliness became a project of orderliness and became institutionalised in society. The water closet is inextricably linked with our present ideas of cleanliness. This could impede a future conversion of the water closet, these ideas in several ways conflicting with the more sustainable toilet system. Nevertheless, it is also a point of this paper to illustrate that our present ideas of cleanliness are not self-evident. On the contrary, our ideas are contextually bound and might thus change, for instance, due to a strengthening of e.g. the environmental discourse

Inaccurate use of asymptotic formulas

The asymptotic form of the plane wave decomposition into spherical waves, which is used to express the scattering amplitude in terms of phase shifts, is incorrect. We explain why and show how to circumvent the mathematical inconsistency.Comment: 3 pages, version to appear in Am. J. Phy

A Model of Colonic Crypts using SBML Spatial

The Spatial Processes package enables an explicit definition of a spatial environment on top of the normal dynamic modeling SBML capabilities. The possibility of an explicit representation of spatial dynamics increases the representation power of SBML. In this work we used those new SBML features to define an extensive model of colonic crypts composed of the main cellular types (from stem cells to fully differentiated cells), alongside their spatial dynamics.Comment: In Proceedings Wivace 2013, arXiv:1309.712

RAB family gene expression in breast cancer cells under influence of paclitaxel

The aim of this study was to investigate the role of paclitaxel on RAB family of genes in primary breast cancer cell lines. The cancer breast cells obtained from 40 women during mastectomy were used to address this issue. The group included patients with intraductal breast cancer - lesions in I or II advancement level by TNM classification and G1-G2 by Bloom classification. (tumor dimensions up to 2.0 cm without metastases to lymph nodes). Cytostatic drugs before surgery were not administered to these patients. The cultures were conducted in 25 cm^2^ plastic containers at RPMI medium with addiction of 10% fetal bovine serum (FBS) at the standard conditions. After reaching concentration levels of 10 000/ml of the cells, the cultures were treated with 60 ng/ml and 300 ng/ml doses of paclitaxel. The concentrations were calculated in relation to therapeutic doses of paclitaxel, applied in polytherapy in patients with breast cancer. The cell cultures untreated for cytostatic were used as a control group. Analysis was conducted for RAB family of genes: RAB3D, RAB5B, RAB5C, RAB7, RAB7L1, RAB9P1, RAB10. RAB11A, RAB311B, RAB13, RAB18, RAB22A, RAB23, RAB26, RAB27A, RAB27B, RAB28, RAB30, RAB31, RAB33A, RAB3D6, RAB 38, RABL2B Total RNA was extracted from the harvest control group and the treated cells, and this was followed by cDNA synthesis, which was used for hybridization assays using arrays. A lower dose of paclitaxel (60 ng/ml) treatment resulted in an increase (2-4 fold- statistically significant), whereas a higher dose (300 ng/ml) caused a decrease (2-fold - statistically insignificant) in expression of examined oncogenes, compared to that of the control group.In summary, this data indicates that 60 ng/ml paclitaxel dose induced the RAB gene expression in an up-regulated pathway. A higher concentration of cytostatic (300 ng/ml) is a toxic dose for primary breast cells in vitro