New flavonoid glycosides from Aconitum naviculare (Bruhl) Stapf, a medicinal herb from the trans-Himalayan region of Nepal

Three new flavonoid glycosides, 3-O-[b-D-glucopyranosyl-(1!3)-(4-O-trans-p-coumaroyl)-a-L-rhamnopyranosyl-(1!6)- b-D-glucopyranosyl]-7-O-[b-D-glucopyranosyl-(1!3)-a-L-rhamnopyranosyl]kaempferol, 3-O-[b-D-glucopyranosyl-(1!3)-(4-Otrans- p-coumaroyl)-a-L-rhamnopyranosyl-(1!6)-b-D-glucopyranosyl]-7-O-[b-D-glucopyranosyl-(1!3)-a-L-rhamnopyranosyl]quercetin and 7-O-[b-D-glucopyranosyl-(1!3)-a-L-rhamnopyranosyl]quercetin were isolated from the aqueous extract of the aerial parts of Aconitum naviculare. Their structures were elucidated by spectral analysis (HRAPI-TOF MS, 1H, 13C NMR, HMQC, HMBC, DFQ-COSY, ROESY and TOCSY)

Diterpenoid alkaloids and phenol glycosides from Aconitum naviculare (Bruhl) Stapf.

Phytochemical investigation of the aerial parts of Aconitum naviculare, a medicinal plant used in traditional Nepalese medicine, led to the isolation and characterization of two new diterpenoid alkaloids, navirine B (1), and navirine C (2), along with (+) chellespontine (3), kaempferol-7-O-\u3b2-D-glucopyranosyl(1\u21923)\u3b1-L-rhamnopyranoside (4), kaempferol-7-O \u3b1-Lrhamnopyranoside, 3-O-\u3b2-D-glucopyranoside (5), p-coumaric-4-O-\u3b2-D-glucopyranoside acid (6), and ferulic-4-O-\u3b2-Dglucopyranoside acid (7). The structures of the isolated compounds were elucidated on the basis of extensive analyses of 1D and 2D NMR spectra (HMQC, HMBC, COSY, ROESY) and HR-MS data. The antiproliferative activity of alkaloids 1-3 against human tumor cell lines (LoVo and 2008) was also evaluated

Two phenolic glycosides from Curculigo orchioides Gaertn

One new glycoside derivative from syringic acid and one new phenol glycoside, curculigoside E (1) and orchioside D (2), were isolated and characterized from the rootstock of Curculigo orchioides collected in the Nawalparasi District (Nepal). The structures of the new isolated compounds were elucidated by means of spectroscopic methods such as 1D, 2D NMR and MS