Controlled delivery of Imatinib mesylate from collagen coated poly(lactic acid) microspheres: In vitro release studies

The development of injectable microspheres for controlled drug delivery to the desired site is a major challenge. We demonstrated the possibility of entrapping an anticancer drug, Imatinib mesylate, in collagen coated biodegradable poly (lactic acid) microspheres with a mean diameter of 10-20 µm. The collagen coating on polymeric matrix surfaces through various surface modification techniques was the current scenario to improve bio-integration of the polymers with the in-vivo system. Here protein adsorption principle is used and various characterization techniques like FTIR, DSC and SEM analysis are used to confirm collagen coating. The reduction in burst release of the Imatinib from the PLA microspheres further confirms its presence and role in controlled release.  This collagen coated PLA microspheres may have potential for the targeted delivery of Imatinib mesylate to treat gastrointestinal stromal tumors, chronic myeloid leukemia cancer

Controlled delivery of Imatinib mesylate from collagen coated poly(lactic acid) microspheres: In vitro release studies

The development of injectable microspheres for controlled drug delivery to the desired site is a major challenge. We demonstrated the possibility of entrapping an anticancer drug, Imatinib mesylate, in collagen coated biodegradable poly (lactic acid) microspheres with a mean diameter of 10-20 µm. The collagen coating on polymeric matrix surfaces through various surface modification techniques was the current scenario to improve bio-integration of the polymers with the in-vivo system. Here protein adsorption principle is used and various characterization techniques like FTIR, DSC and SEM analysis are used to confirm collagen coating. The reduction in burst release of the Imatinib from the PLA microspheres further confirms its presence and role in controlled release.  This collagen coated PLA microspheres may have potential for the targeted delivery of Imatinib mesylate to treat gastrointestinal stromal tumors, chronic myeloid leukemia cancer

Biodegradable graft hydrogel membranes for in-vitro release studies of Levofloxacin Hemihydrate drug

Controlled release of Levofloxacin Hemihydrate drug through Methyl Methacrylate grafted Poly (vinyl alcohol) (PVA-g-MMA) hydrogel membranes have been investigated. These graft co-polymer hydrogel membranes of various formulations were prepared using conventional solution casting method by varying, monomer, cross-linker and drug content. An attempt has been made to characterize these hydrogel membranes by various instrumental techniques like, Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). The release patterns of the drug from the hydrogel membrane were carried out in pH 7.4 media and the samples were analysed spectrophotometrically at 294 nm wavelength on a UV Vis spectrophotometer. The mechanical properties of the hydrogel membranes were characterized by UTM. FTIR spectra of the membranes indicated complete esterification of the free carboxyl groups of Methyl Methacrylate. XRD studies indicated that the crystallinity of the membranes was mainly due to Methyl Methacrylate. The experimental results indicated that the hydrogel membrane could be tried for various biomedical application

Biodegradable graft hydrogel membranes for in-vitro release studies of Levofloxacin Hemihydrate drug

Controlled release of Levofloxacin Hemihydrate drug through Methyl Methacrylate grafted Poly (vinyl alcohol) (PVA-g-MMA) hydrogel membranes have been investigated. These graft co-polymer hydrogel membranes of various formulations were prepared using conventional solution casting method by varying, monomer, cross-linker and drug content. An attempt has been made to characterize these hydrogel membranes by various instrumental techniques like, Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). The release patterns of the drug from the hydrogel membrane were carried out in pH 7.4 media and the samples were analysed spectrophotometrically at 294 nm wavelength on a UV Vis spectrophotometer. The mechanical properties of the hydrogel membranes were characterized by UTM. FTIR spectra of the membranes indicated complete esterification of the free carboxyl groups of Methyl Methacrylate. XRD studies indicated that the crystallinity of the membranes was mainly due to Methyl Methacrylate. The experimental results indicated that the hydrogel membrane could be tried for various biomedical application

Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

This article reports the fabrication of pH-sensitive microbeads from sodium alginate (SA) and modified karaya gum (KG). KG was modified by graft copolymerization using 2-hydroxyethyl methacrylate (2-HEMA) through in situ free radical polymerization reaction. The graft copolymer was blended with SA to develop microbeads by a simple ionotropic gelation technique. The microbeads were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and scanning electron microscopy. The effect of %HEMA and polymer blend ratio on the swelling capacity was investigated. Drug release kinetics of the microbeads was investigated under both pH 7.4 and pH 1.2 at 37°C. The drug release kinetics was analyzed by evaluating the release data using different kinetic models. </jats:p