A novel method to obtain modulus image of soft tissues using ultrasound water jet indentation : a phantom study

2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Ultrasound elastomicroscopy using water beam indentation : preliminary study

Author name used in this publication: M. H. LuAuthor name used in this publication: Y. P. ZhengAuthor name used in this publication: Q. H. Huang2004-2005 > Academic research: not refereed > Chapter in an edited book (author)Accepted ManuscriptPublishe

3-D measurement of body tissues based on ultrasound images with 3-D spatial information

2005-2006 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Development of a portable 3D ultrasound imaging system for musculoskeletal tissues

Author name used in this publication: Q. H. HuangAuthor name used in this publication: Y. P. ZhengAuthor name used in this publication: M. H. LuAuthor name used in this publication: Z. R. ChiCentre for Signal Processing, Department of Electronic and Information EngineeringRehabilitation Engineering Centre2004-2005 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

A novel noncontact ultrasound indentation system for measurement of tissue material properties using water jet compression

Author name used in this publication: M. H. LuAuthor name used in this publication: Y. P. ZhengAuthor name used in this publication: Q. H. Huang2004-2005 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

A new adaptive interpolation algorithm for 3D ultrasound imaging with speckle reduction and edge preservation

Author name used in this publication: Qinghua HuangAuthor name used in this publication: Yongping ZhengAuthor name used in this publication: Minhua Lu2008-2009 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Novel silica stabilization method for the analysis of fine nanocrystals using coherent X-ray diffraction imaging

High-energy X-ray Bragg coherent diffraction imaging (BCDI) is a well established synchrotron-based technique used to quantitatively reconstruct the three-dimensional morphology and strain distribution in nanocrystals. The BCDI technique has become a powerful analytical tool for quantitative investigations of nanocrystals, nanotubes, nanorods and more recently biological systems. BCDI has however typically failed for fine nanocrystals in sub-100 nm size regimes – a size routinely achievable by chemical synthesis – despite the spatial resolution of the BCDI technique being 20–30 nm. The limitations of this technique arise from the movement of nanocrystals under illumination by the highly coherent beam, which prevents full diffraction data sets from being acquired. A solution is provided here to overcome this problem and extend the size limit of the BCDI technique, through the design of a novel stabilization method by embedding the fine nanocrystals into a silica matrix. Chemically synthesized FePt nanocrystals of maximum dimension 20 nm and AuPd nanocrystals in the size range 60–65 nm were investigated with BCDI measurement at beamline 34-ID-C of the APS, Argonne National Laboratory. Novel experimental methodologies to elucidate the presence of strain in fine nanocrystals are a necessary pre-requisite in order to better understand strain profiles in engineered nanocrystals for novel device development

A Upf3b-mutant mouse model with behavioral and neurogenesis defects.

Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts. NMD is regulated in a tissue-specific and developmentally controlled manner, raising the possibility that it influences developmental events. Indeed, loss or depletion of NMD factors have been shown to disrupt developmental events in organisms spanning the phylogenetic scale. In humans, mutations in the NMD factor gene, UPF3B, cause intellectual disability (ID) and are strongly associated with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and schizophrenia (SCZ). Here, we report the generation and characterization of mice harboring a null Upf3b allele. These Upf3b-null mice exhibit deficits in fear-conditioned learning, but not spatial learning. Upf3b-null mice also have a profound defect in prepulse inhibition (PPI), a measure of sensorimotor gating commonly deficient in individuals with SCZ and other brain disorders. Consistent with both their PPI and learning defects, cortical pyramidal neurons from Upf3b-null mice display deficient dendritic spine maturation in vivo. In addition, neural stem cells from Upf3b-null mice have impaired ability to undergo differentiation and require prolonged culture to give rise to functional neurons with electrical activity. RNA sequencing (RNAseq) analysis of the frontal cortex identified UPF3B-regulated RNAs, including direct NMD target transcripts encoding proteins with known functions in neural differentiation, maturation and disease. We suggest Upf3b-null mice serve as a novel model system to decipher cellular and molecular defects underlying ID and neurodevelopmental disorders

Evaluation of bone-tendon junction healing using water jet ultrasound indentation method

2009-2010 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Identity-based remote data integrity checking with perfect data privacy preserving for cloud storage

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Remote data integrity checking (RDIC) enables a data storage server, such as a cloud server, to prove to a verifier that it is actually storing a data owner’s data honestly. To date, a number of RDIC protocols have been proposed in the literature, but almost all the constructions suffer from the issue of a complex key management, that is, they rely on the expensive public key infrastructure (PKI), which might hinder the deployment of RDIC in practice. In this paper, we propose a new construction of identity-based (ID-based) RDIC protocol by making use of key-homomorphic cryptographic primitive to reduce the system complexity and the cost for establishing and managing the public key authentication framework in PKI based RDIC schemes. We formalize ID-based RDIC and its security model including security against a malicious cloud server and zero knowledge privacy against a third party verifier. We then provide a concrete construction of ID-based RDIC scheme which leaks no information of the stored files to the verifier during the RDIC process. The new construction is proven secure against the malicious server in the generic group model and achieves zero knowledge privacy against a verifier. Extensive security analysis and implementation results demonstrate that the proposed new protocol is provably secure and practical in the real-world applications.This work is supported by the National Natural Science Foundation of China (61501333,61300213,61272436,61472083), Fok Ying Tung Education Foundation (141065), Program for New Century Excellent Talents in Fujian University (JA1406