U-shaped fairings suppress vortex-induced vibrations for cylinders in cross-flow

We employ three-dimensional direct and large-eddy numerical simulations of the vibrations and flow past cylinders fitted with free-to-rotate U-shaped fairings placed in a cross-flow at Reynolds number 100 ⩽ Re ⩽ 10,000. Such fairings are nearly neutrally buoyant devices fitted along the axis of long circular risers to suppress vortex-induced vibrations (VIVs). We consider three different geometric configurations: a homogeneous fairing, and two configurations (denoted A and AB) involving a gap between adjacent segments. For the latter two cases, we investigate the effect of the gap on the hydrodynamic force coefficients and the translational and rotational motions of the system. For all configurations, as the Reynolds number increases beyond 500, both the lift and drag coefficients decrease. Compared to a plain cylinder, a homogeneous fairing system (no gaps) can help reduce the drag force coefficient by 15 % for reduced velocity U* = 4.65, while a type A gap system can reduce the drag force coefficient by almost 50 % for reduced velocity U* = 3.5, 4.65, 6, and, correspondingly, the vibration response of the combined system, as well as the fairing rotation amplitude, are substantially reduced. For a homogeneous fairing, the cross-flow amplitude is reduced by about 80 %, whereas for fairings with a gap longer than half a cylinder diameter, VIVs are completely eliminated, resulting in additional reduction in the drag coefficient. We have related such VIV suppression or elimination to the features of the wake flow structure. We find that a gap causes the generation of strong streamwise vorticity in the gap region that interferes destructively with the vorticity generated by the fairings, hence disorganizing the formation of coherent spanwise cortical patterns. We provide visualization of the incoherent wake flow that leads to total elimination of the vibration and rotation of the fairing–cylinder system. Finally, we investigate the effect of the friction coefficient between cylinder and fairing. The effect overall is small, even when the friction coefficients of adjacent segments are different. In some cases the equilibrium positions of the fairings are rotated by a small angle on either side of the centreline, in a symmetry-breaking bifurcation, which depends strongly on Reynolds number

U-shaped fairings suppress vortex-induced vibrations for cylinders in cross-flow

We employ three-dimensional direct and large-eddy numerical simulations of the vibrations and flow past cylinders fitted with free-to-rotate U-shaped fairings placed in a cross-flow at Reynolds number 100 ⩽ Re ⩽ 10,000. Such fairings are nearly neutrally buoyant devices fitted along the axis of long circular risers to suppress vortex-induced vibrations (VIVs). We consider three different geometric configurations: a homogeneous fairing, and two configurations (denoted A and AB) involving a gap between adjacent segments. For the latter two cases, we investigate the effect of the gap on the hydrodynamic force coefficients and the translational and rotational motions of the system. For all configurations, as the Reynolds number increases beyond 500, both the lift and drag coefficients decrease. Compared to a plain cylinder, a homogeneous fairing system (no gaps) can help reduce the drag force coefficient by 15 % for reduced velocity U* = 4.65, while a type A gap system can reduce the drag force coefficient by almost 50 % for reduced velocity U* = 3.5, 4.65, 6, and, correspondingly, the vibration response of the combined system, as well as the fairing rotation amplitude, are substantially reduced. For a homogeneous fairing, the cross-flow amplitude is reduced by about 80 %, whereas for fairings with a gap longer than half a cylinder diameter, VIVs are completely eliminated, resulting in additional reduction in the drag coefficient. We have related such VIV suppression or elimination to the features of the wake flow structure. We find that a gap causes the generation of strong streamwise vorticity in the gap region that interferes destructively with the vorticity generated by the fairings, hence disorganizing the formation of coherent spanwise cortical patterns. We provide visualization of the incoherent wake flow that leads to total elimination of the vibration and rotation of the fairing–cylinder system. Finally, we investigate the effect of the friction coefficient between cylinder and fairing. The effect overall is small, even when the friction coefficients of adjacent segments are different. In some cases the equilibrium positions of the fairings are rotated by a small angle on either side of the centreline, in a symmetry-breaking bifurcation, which depends strongly on Reynolds number

The role of external broadcasting in a closed political system

This article investigates the role and impact of external broadcasting (radio and television) on a closed political system, through the example of the two post-war German states: the West German Federal Republic of Germany (FRG) and the East German German Democratic Republic (GDR). The aim is to debunk myths about the influence of external broadcasting on the events that led to German reunification in 1990. The study follows a historical approach and discusses what role external media played during the years of a divided Germany. The findings are based on several historical sources, research reports from the 1950s and 1960s and over 100 biographical interviews with former residents of the German Democratic Republic (GDR). The article analyses the impact of external broadcasting on citizens and the political elite in times of crisis as well as during everyday life

Analysis of the giant genomes of Fritillaria (Liliaceae) indicates that a lack of DNA removal characterizes extreme expansions in genome size.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Plants exhibit an extraordinary range of genome sizes, varying by > 2000-fold between the smallest and largest recorded values. In the absence of polyploidy, changes in the amount of repetitive DNA (transposable elements and tandem repeats) are primarily responsible for genome size differences between species. However, there is ongoing debate regarding the relative importance of amplification of repetitive DNA versus its deletion in governing genome size. Using data from 454 sequencing, we analysed the most repetitive fraction of some of the largest known genomes for diploid plant species, from members of Fritillaria. We revealed that genomic expansion has not resulted from the recent massive amplification of just a handful of repeat families, as shown in species with smaller genomes. Instead, the bulk of these immense genomes is composed of highly heterogeneous, relatively low-abundance repeat-derived DNA, supporting a scenario where amplified repeats continually accumulate due to infrequent DNA removal. Our results indicate that a lack of deletion and low turnover of repetitive DNA are major contributors to the evolution of extremely large genomes and show that their size cannot simply be accounted for by the activity of a small number of high-abundance repeat families.Thiswork was supported by the Natural Environment ResearchCouncil (grant no. NE/G017 24/1), the Czech Science Fou nda-tion (grant no. P501/12/G090), the AVCR (grant no.RVO:60077344) and a Beatriu de Pinos postdoctoral fellowshipto J.P. (grant no. 2011-A-00292; Catalan Government-E.U. 7thF.P.)

Aplastic Crisis as Primary Manifestation of Systemic Lupus Erythematosus

Aplastic crisis is an unusual feature of systemic lupus erythematosus (SLE). We report the case of a 54-year-old woman presenting with both (extravascular) Coombs-positive hemolytic anemia and laboratory findings of bone marrow hyporegeneration with concomitant severe neutropenia. A bone marrow biopsy confirmed aplastic crisis. Diagnostic work-up revealed soaring titers of autoantibodies (anti-nuclear, anti-double-stranded DNA, anti-cardiolipin-IgM, and anti-beta 2-glykoprotein-IgM antibodies), indicating a connective tissue disease as the most plausible reason for bone marrow insufficiency. As the criteria for SLE were fulfilled, we initiated an immunosuppressive therapy by steroids, which led to a rapid complete hematologic and clinical remission in our patient. In this case, we could report on one of the rare cases of SLE-induced aplastic crisis showing that this condition can be entirely reversed by immunosuppressive treatment and that SLE-induced aplastic crisis yields a good prognosis. In conclusion, in a case of aplastic crisis, physicians should be aware that SLE can be a rare cause that is accessible to specific treatment

Drawing Trees with Perfect Angular Resolution and Polynomial Area

We study methods for drawing trees with perfect angular resolution, i.e., with angles at each node v equal to 2{\pi}/d(v). We show: 1. Any unordered tree has a crossing-free straight-line drawing with perfect angular resolution and polynomial area. 2. There are ordered trees that require exponential area for any crossing-free straight-line drawing having perfect angular resolution. 3. Any ordered tree has a crossing-free Lombardi-style drawing (where each edge is represented by a circular arc) with perfect angular resolution and polynomial area. Thus, our results explore what is achievable with straight-line drawings and what more is achievable with Lombardi-style drawings, with respect to drawings of trees with perfect angular resolution.Comment: 30 pages, 17 figure

Efficacy of an intensive outpatient rehabilitation program in alcoholism: Predictors of outcome 6 months after treatment

Treatment of alcohol-dependent patients was primarily focused on inpatient settings in the past decades. The efficacy of these treatment programs has been evaluated in several studies and proven to be sufficient. However, with regard to the increasing costs in public healthcare systems, questions about alternative treatment strategies have been raised. Meanwhile, there is growing evidence that outpatient treatment might be comparably effective as inpatient treatment, at least for subgroups of alcohol dependents. On that background, the present study aimed to evaluate the efficacy of a high-structured outpatient treatment program in 103 alcohol-dependent patients. 74 patients (72%) terminated the outpatient treatment regularly. At 6 months' follow-up, 95% patients were successfully located and personally re-interviewed. Analyses revealed that 65 patients (64%) were abstinent at the 6-month follow-up evaluation and 37 patients ( 36%) were judged to be non-abstinent. Pretreatment variables which were found to have a negative impact (non-abstinence) on the 6-month outcome after treatment were a higher severity of alcohol dependence measured by a longer duration of alcohol dependence, a higher number of prior treatments and a stronger alcohol craving (measured by the Obsessive Compulsive Drinking Scale). Further patients with a higher degree of psychopathology measured by the Beck Depression Inventory (depression) and State-Trait Anxiety Inventory (anxiety) relapsed more often. In summary, results of this study indicate a favorable outcome of socially stable alcohol-dependent patients and patients with a lower degree of depression, anxiety and craving in an intensive outpatient rehabilitation program

Lymphatic Filariasis Control in Tanzania: Effect of Six Rounds of Mass Drug Administration with Ivermectin and Albendazole on Infection and Transmission.

Control of lymphatic filariasis (LF) in most countries of sub-Saharan Africa is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. We present findings from a detailed study on the effect of six rounds of MDA with this drug combination as implemented by the National Lymphatic Filariasis Elimination Programme (NLFEP) in a highly endemic rural area of north-eastern Tanzania.\ud The effect of treatment on transmission and human infection was monitored in a community- and a school-based study during an 8-year period (one pre-intervention and 7 post-intervention years) from 2003 to 2011. Before intervention, 24.5% of the community population had microfilariae (mf) in the blood, 53.3% had circulating filarial antigens (CFA) and 78.9% had specific antibodies to the recombinant filarial antigen Bm14. One year after the sixth MDA, these values had decreased considerably to 2.7%, 19.6% and 27.5%, respectively. During the same period, the CFA prevalence among new intakes of Standard 1 pupils in 10 primary schools decreased from 25.2% to 5.6%. In line with this, transmission by the three vectors (Anopheles gambiae, An. funestus and Culex quinquefasciatus) as determined by dissection declined sharply (overall vector infectivity rate by 99.3% and mean monthly transmission potential by 99.2% between pre-intervention and fifth post-intervention period). A major shift in vector species composition, from predominantly anopheline to almost exclusively culicine was observed over the years. This may be largely unrelated to the MDAs but may have important implications for the epidemiology of LF in the area. Six MDAs caused considerable decrease in all the measured indices for transmission and human infection. In spite of this, indices were still relatively high in the late period of the study, and it may take a long time to reach the recommended cut-off levels for interruption of transmission unless extra efforts are made. These should include increased engagement of the target population in the control activities, to ensure higher treatment coverage. It is expected that the recent initiative to distribute insecticide impregnated bed nets to every household in the area will also contribute towards reaching the goal of successful LF elimination

Molecular Gas in the Host Galaxy of a Quasar at Redshift z=6.42

Observations of the molecular gas phase in quasar host galaxies provide fundamental constraints on galaxy evolution at the highest redshifts. Molecular gas is the material out of which stars form; it can be traced by spectral line emission of carbon--monoxide (CO). To date, CO emission has been detected in more than a dozen quasar host galaxies with redshifts (z) larger 2, the record holder being at z=4.69. At these distances the CO lines are shifted to longer wavelengths, enabling their observation with sensitive radio and millimetre interferometers. Here we present the discovery of CO emission toward the quasar SDSS J114816.64+525150.3 (hereafter J1148+5251) at a redshift of z=6.42, when the universe was only 1/16 of its present age. This is the first detection of molecular gas at the end of cosmic reionization. The presence of large amounts of molecular gas (M(H_2)=2.2e10 M_sun) in an object at this time demonstrates that heavy element enriched molecular gas can be generated rapidly in the earliest galaxies.Comment: 12 pages, 2 figures. To appear in Nature, July, 200