13,261 research outputs found
User data dissemination concepts for earth resources
Domestic data dissemination networks for earth-resources data in the 1985-1995 time frame were evaluated. The following topics were addressed: (1) earth-resources data sources and expected data volumes, (2) future user demand in terms of data volume and timeliness, (3) space-to-space and earth point-to-point transmission link requirements and implementation, (4) preprocessing requirements and implementation, (5) network costs, and (6) technological development to support this implementation. This study was parametric in that the data input (supply) was varied by a factor of about fifteen while the user request (demand) was varied by a factor of about nineteen. Correspondingly, the time from observation to delivery to the user was varied. This parametric evaluation was performed by a computer simulation that was based on network alternatives and resulted in preliminary transmission and preprocessing requirements. The earth-resource data sources considered were: shuttle sorties, synchronous satellites (e.g., SEOS), aircraft, and satellites in polar orbits
k-d Darts: Sampling by k-Dimensional Flat Searches
We formalize the notion of sampling a function using k-d darts. A k-d dart is
a set of independent, mutually orthogonal, k-dimensional subspaces called k-d
flats. Each dart has d choose k flats, aligned with the coordinate axes for
efficiency. We show that k-d darts are useful for exploring a function's
properties, such as estimating its integral, or finding an exemplar above a
threshold. We describe a recipe for converting an algorithm from point sampling
to k-d dart sampling, assuming the function can be evaluated along a k-d flat.
We demonstrate that k-d darts are more efficient than point-wise samples in
high dimensions, depending on the characteristics of the sampling domain: e.g.
the subregion of interest has small volume and evaluating the function along a
flat is not too expensive. We present three concrete applications using line
darts (1-d darts): relaxed maximal Poisson-disk sampling, high-quality
rasterization of depth-of-field blur, and estimation of the probability of
failure from a response surface for uncertainty quantification. In these
applications, line darts achieve the same fidelity output as point darts in
less time. We also demonstrate the accuracy of higher dimensional darts for a
volume estimation problem. For Poisson-disk sampling, we use significantly less
memory, enabling the generation of larger point clouds in higher dimensions.Comment: 19 pages 16 figure
User data dissemination concepts for earth resources: Executive summary
The impact of the future capabilities of earth-resources data sensors (both satellite and airborne) and their requirements on the data dissemination network were investigated and optimum ways of configuring this network were determined. The scope of this study was limited to the continental U.S.A. (including Alaska) and to the 1985-1995 time period. Some of the conclusions and recommendations reached were: (1) Data from satellites in sun-synchronous polar orbits (700-920 km) will generate most of the earth-resources data in the specified time period. (2) Data from aircraft and shuttle sorties cannot be readily integrated in a data-dissemination network unless already preprocessed in a digitized form to a standard geometric coordinate system. (3) Data transmission between readout stations and central preprocessing facilities, and between processing facilities and user facilities are most economically performed by domestic communication satellites. (4) The effect of the following factors should be studied: cloud cover, expanded coverage, pricing strategies, multidiscipline missions
VoroCrust: Voronoi Meshing Without Clipping
Polyhedral meshes are increasingly becoming an attractive option with
particular advantages over traditional meshes for certain applications. What
has been missing is a robust polyhedral meshing algorithm that can handle broad
classes of domains exhibiting arbitrarily curved boundaries and sharp features.
In addition, the power of primal-dual mesh pairs, exemplified by
Voronoi-Delaunay meshes, has been recognized as an important ingredient in
numerous formulations. The VoroCrust algorithm is the first provably-correct
algorithm for conforming polyhedral Voronoi meshing for non-convex and
non-manifold domains with guarantees on the quality of both surface and volume
elements. A robust refinement process estimates a suitable sizing field that
enables the careful placement of Voronoi seeds across the surface circumventing
the need for clipping and avoiding its many drawbacks. The algorithm has the
flexibility of filling the interior by either structured or random samples,
while preserving all sharp features in the output mesh. We demonstrate the
capabilities of the algorithm on a variety of models and compare against
state-of-the-art polyhedral meshing methods based on clipped Voronoi cells
establishing the clear advantage of VoroCrust output.Comment: 18 pages (including appendix), 18 figures. Version without compressed
images available on https://www.dropbox.com/s/qc6sot1gaujundy/VoroCrust.pdf.
Supplemental materials available on
https://www.dropbox.com/s/6p72h1e2ivw6kj3/VoroCrust_supplemental_materials.pd
High‐sensitivity cardiac troponin after cardiac stress test: A systematic review and meta‐analysis
Planar Airy beam light-sheet for two-photon microscopy
We demonstrate the first planar Airy light-sheet microscope. Fluorescence
light-sheet microscopy has become the method of choice to study large
biological samples with cellular or sub-cellular resolution. The
propagation-invariant Airy beam enables a ten-fold increase in field-of-view
with single-photon excitation; however, the characteristic asymmetry of the
light-sheet limits its potential for multi-photon excitation. Here we show how
a planar light-sheet can be formed from the curved propagation-invariant Airy
beam. The resulting symmetric light sheet excites two-photon fluorescence
uniformly across an extended field-of-view without the need for deconvolution.
We demonstrate the method for rapid two-photon imaging of large volumes of
neuronal tissue.Comment: 7 pages, 4 figure
TEMPORAL ROUTINES FOR GENERATIONAL PRODUCT INNOVATION IN COMPUTER SOFTWARE
IN COMPUTER SOFTWARE This study uses a routines-based theoretical lens to examine time-based pacing of generational product innovation in the applications software industry. We develop a temporal routines model to explain the effect of time since previous innovation on generational product innovation. The model further suggests that organizational size moderates the time-pacing relationship. Employing event history analysis, we examined forty-six organizations competing in four segments of business productivity software from 1994 to 1998. We found empirical evidence consistent with our temporal routines model, indicating that software organizations, particularly larger organizations, employ temporal routines for generational product innovation. TEMPORAL ROUTINES FOR GENERATIONAL PRODUCT INNOVATION IN COMPUTER SOFTWARE Time-based pacing of innovation has drawn recent interest from academics (Brown and Eisenhardt, 1997; Bluedorn, 2002) and practitioners (Economist, 2003). Time-based pacing typically involves generational forms of innovation. A generational product innovation represents a significant advance in the technical performance of an existing product (Lawless an
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Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality.
Metabolic adaptation is linked to the ability of the opportunistic pathogen Candida albicans to colonize and cause infection in diverse host tissues. One way that C. albicans controls its metabolism is through the glucose repression pathway, where expression of alternative carbon source utilization genes is repressed in the presence of its preferred carbon source, glucose. Here we carry out genetic and gene expression studies that identify transcription factors Mig1 and Mig2 as mediators of glucose repression in C. albicans. The well-studied Mig1/2 orthologs ScMig1/2 mediate glucose repression in the yeast Saccharomyces cerevisiae; our data argue that C. albicans Mig1/2 function similarly as repressors of alternative carbon source utilization genes. However, Mig1/2 functions have several distinctive features in C. albicans. First, Mig1 and Mig2 have more co-equal roles in gene regulation than their S. cerevisiae orthologs. Second, Mig1 is regulated at the level of protein accumulation, more akin to ScMig2 than ScMig1. Third, Mig1 and Mig2 are together required for a unique aspect of C. albicans biology, the expression of several pathogenicity traits. Such Mig1/2-dependent traits include the abilities to form hyphae and biofilm, tolerance of cell wall inhibitors, and ability to damage macrophage-like cells and human endothelial cells. Finally, Mig1 is required for a puzzling feature of C. albicans biology that is not shared with S. cerevisiae: the essentiality of the Snf1 protein kinase, a central eukaryotic carbon metabolism regulator. Our results integrate Mig1 and Mig2 into the C. albicans glucose repression pathway and illuminate connections among carbon control, pathogenicity, and Snf1 essentiality
Spoke-Darts for High-Dimensional Blue-Noise Sampling
Blue noise sampling has proved useful for many graphics applications, but
remains underexplored in high-dimensional spaces due to the difficulty of
generating distributions and proving properties about them. We present a blue
noise sampling method with good quality and performance across different
dimensions. The method, spoke-dart sampling, shoots rays from prior samples and
selects samples from these rays. It combines the advantages of two major
high-dimensional sampling methods: the locality of advancing front with the
dimensionality-reduction of hyperplanes, specifically line sampling. We prove
that the output sampling is saturated with high probability, with bounds on
distances between pairs of samples and between any domain point and its nearest
sample. We demonstrate spoke-dart applications for approximate Delaunay graph
construction, global optimization, and robotic motion planning. Both the
blue-noise quality of the output distribution and the adaptability of the
intermediate processes of our method are useful in these applications.Comment: 19 pages, 22 figure
Multi-soliton energy transport in anharmonic lattices
We demonstrate the existence of dynamically stable multihump solitary waves
in polaron-type models describing interaction of envelope and lattice
excitations. In comparison with the earlier theory of multihump optical
solitons [see Phys. Rev. Lett. {\bf 83}, 296 (1999)], our analysis reveals a
novel physical mechanism for the formation of stable multihump solitary waves
in nonintegrable multi-component nonlinear models.Comment: 4 pages, 4 figure
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