Optimization in offshore supply vessel planning

This paper considers the offshore supply vessel (OSV) planning problem, which consists of determining an optimal fleet size and mix of OSVs as well as their weekly routes and schedules for servicing offshore oil and gas installations. The work originates from a project with Statoil, the leading operator on the Norwegian continental shelf. We present both a new arc-flow and a voyage-based model for solving the OSV planning problem. A decision support tool based on the voyage-based model has been used by planners in Statoil, and cost savings from this was estimated to approximately 3 million USD/year. Weather conditions at the Norwegian continental shelf can be harsh; wave heights may limit both an OSV’s sailing speed and the time to perform unloading/loading operations at the installations. Hence, we analyze the weather impact on the execution of a schedule and propose robustness approaches to obtain solutions that can better withstand delays due to rough weather. Simulations indicate that such solutions both are more robust and have lower expected costs.acceptedVersio

Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders

Several types of biodegradable materials have been investigated for the treatment of osteomyelitis. Calcium phosphate (CaP) ceramics are among the most performing materials due to their resemblance to human hard tissues in terms of mineralogical composition, and proven ability to adsorb and deliver a number of drugs. This research work was intended to study the suitability of modified CaP powders loaded with a fluoroquinolone as drug delivery systems for osteomyelitis treatment. Levofloxacin (LEV) was chosen due to the well-recognized antistaphylococcal activity and adequate penetration into osteoarticular tissues. Substituted CaP powders (5 mol% Sr2+ or 5 mol% Mg2+) were synthesised through aqueous precipitation. The obtained powders were characterised by X-ray diffraction, SEM and FTIR analysis. The X-ray diffraction patterns confirmed the presence of HA and beta-tricalcium phosphates (beta-TCP) phases in doped compositions, especially in the case of Mg-doped system. The fixation of LEV at the surface of the particles occurred only by physisorption. Both the in vitro microbiological susceptibility, against Staphylococcus spp, and biocompatibility of LEV-loaded CaP powders have not been compromised