Job satisfaction among Malaysian employees: An application of Spector’s Job Satisfaction Survey in the South East Asian context.

Job satisfaction explains individuals’ reactions towards their jobs. Many studies find that job satisfaction is a well-known construct that is widely used to study work-related well-being; and contributes significantly to employees’ overall quality of life. The current paper examines job satisfaction among Malaysian employees using the Job Satisfaction Survey (JSS). In particular, the present study compares the job satisfaction levels of Malaysian samples with those of a previously reported study involving samples from Singapore and the United States. Results of one sample t-test reveals statistically significant differences in pay, promotion, fringe benefits, contingent rewards, supervision, co-workers and nature of work subscales. No cultural influence exists between Malaysian and Singapore samples in terms of perceived operating conditions satisfaction. Similarly, no statistically significant difference exists between Malaysian and the United States perception towards the communication facet. Furthermore, the results of factor analysis support the previous study, suggesting possible cultural differences in the understanding of, and consensus regarding, the structure of the job satisfaction scale

Probing CP Violation with and without Momentum Reconstruction at the LHC

We study the potential to observe CP-violating effects in SUSY cascade decay chains at the LHC. We consider squark and gluino production followed by subsequent decays into neutralinos with a three-body leptonic decay in the final step. Asymmetries composed by triple products of momenta of the final state particles are sensitive to CP-violating effects. Due to large boosts these asymmetries can be difficult to observe at a hadron collider. We show that using all available kinematic information one can reconstruct the decay chains on an event-by-event basis even in the case of 3-body decays, neutrinos and LSPs in the final state. We also discuss the most important experimental effects like major backgrounds and momentum smearing due to finite detector resolution. We show that with 300 fb$^{-1}$ of collected data, CP violation may be discovered at the LHC for a wide range of the phase of the bino mass parameter $M_1$.Comment: Version accepted for publication in JHEP. Clarifications added on the assumptions used for plots. New references adde

Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge are protected against a secondary lethal challenge. Using RAGγc knock-out mice we show that this protection is independent of T, B and NK cells. In protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocytosis and killing. Protection was also associated with an enhanced expression of CXCR2 and Dectin-1 on bone marrow phagocytes. We also show that protective lung cytokine and chemokine responses are induced more rapidly and with enhanced dynamics in protected mice. Our findings support the hypothesis that following a first encounter with a non-lethal dose of A. fumigatus conidia, the innate immune system is primed and can mediate protection against a secondary lethal infection

Association between proton pump inhibitor therapy and clostridium difficile infection: a contemporary systematic review and meta-analysis.

Abstract Introduction Emerging epidemiological evidence suggests that proton pump inhibitor (PPI) acid-suppression therapy is associated with an increased risk of Clostridium difficile infection (CDI). Methods Ovid MEDLINE, EMBASE, ISI Web of Science, and Scopus were searched from 1990 to January 2012 for analytical studies that reported an adjusted effect estimate of the association between PPI use and CDI. We performed random-effect meta-analyses. We used the GRADE framework to interpret the findings. Results We identified 47 eligible citations (37 case-control and 14 cohort studies) with corresponding 51 effect estimates. The pooled OR was 1.65, 95% CI (1.47, 1.85), I2 = 89.9%, with evidence of publication bias suggested by a contour funnel plot. A novel regression based method was used to adjust for publication bias and resulted in an adjusted pooled OR of 1.51 (95% CI, 1.26–1.83). In a speculative analysis that assumes that this association is based on causality, and based on published baseline CDI incidence, the risk of CDI would be very low in the general population taking PPIs with an estimated NNH of 3925 at 1 year. Conclusions In this rigorously conducted systemic review and meta-analysis, we found very low quality evidence (GRADE class) for an association between PPI use and CDI that does not support a cause-effect relationship

Effect of whole-body vibration on muscle strength, spasticity, and motor performance in spastic diplegic cerebral palsy children

Background and purpose: Spastic diplegia is a common form of cerebral palsy (CP) and is characterized by spasticity and muscle weakness of both lower limbs resulting in decreased walking ability. The purpose of this study was to evaluate the effect of whole body vibration (WBV) training on muscle strength, spasticity, and motor performance in spastic diplegic cerebral palsy children after 12-weeks treatment.Methods: Thirty spastic diplegic CP children (8–12 years) were randomized to two equal groups, control group and WBV group. The control group received a selected physical therapy treatment program for spastic diplegic CP and the WBV group received the same program in addition to WBV training. Measurements of isometric strength of knee extensors, spasticity, walking speed, walking balance and gross motor function were performed before and after 12 weeks of the treatment program.Results: Isometric strength of knee extensors, spasticity and the walking speed were significantly improved only in the WBV group (P < 0.05). Growth motor function measure-88 (GMFM-88) (D%) was significantly increased (P < 0.05) in both groups in favor of the WBV group and GMFM-88 (E%) was significantly increased (P < 0.05) only in the WBV group, while walking balance did not change significantly in either group.Conclusion: The obtained results suggest that 12-weeks’ intervention of whole-body vibration training can increase knee extensors strength and decrease spasticity with beneficial effects on walking speed and motor development in spastic diplegic CP childrenKeywords: Whole body vibration; Cerebral palsy; Spastic diplegia; Walking balance; Motor developmen

Non-parametric data optimization for 2D laser based people tracking

© 2017 IEEE. Generally, a model on describing human motion patterns should have an ability to enhance tracking performance particularly when dealing with long term occlusions. These patterns can be efficiently learned by applying Gaussian Processes (GPs). However, the GPs can become computationally expensive with increasing training data with time. Thus, with the proposed data selection and management using Mutual Information (MI) and Mahalanobis Distance (MD)approach, we have be able to keep the necessary portion of informative data and discard the others. This approach is then experimented by using the measurements of horizontal 2D scan of public area of our research centre with a stationary laser range finder. Experimental results show that even 90% reduction of data did not contribute to significantly increased Root Mean Square Error (RMSE). Implementation of Gaussian Process - Particle filter tracker for people tracking with long term occlusions produces a remarkable tracking performance when compared to Extended Kalman Filter (EKF) tracker

Effect of resistance and aerobic exercises on bone mineral density, muscle strength and functional ability in children with hemophilia

Background and purpose: Children with hemophilia are at risk for reduced bone mineral density (BMD), muscle strength and functional ability as a result of reduced leisure-time activity and less involvement in intense activities. So, the purpose of this study was to investigate the effect of resistance and aerobic exercise program on BMD, muscle strength and functional ability in children with hemophilia.Materials and methods: Thirty boys with hemophilia A ranging in age from 10 to 14 years had participated in this study. They were assigned randomly into two equal groups (control and study groups). Control group received a designed physical therapy program and aerobic exercise in the form of treadmill training, while the study group received the same program as the control group in addition to resistance training program in the form of bicycle ergometer training and weight resistance. Both groups received treatment sessions three times per week for three successive months. BMD, muscle strength of knee flexors and extensors and functional ability were evaluated before and after the 3 months of treatment program.Results: There was no significant difference between both groups in the pre-treatment mean values of all measured variables. Significant improvement was observed in BMD, knee extensors and flexors strength, and functional ability in the study group when comparing pre and post treatment measurements. There was a significant improvement in functional ability of the control group. Significant difference was also observed between both groups when comparing the post treatment measurements in favor of the study group.Conclusion: Based on obtained data, it can be concluded that, resistance and aerobic exercise training program is effective in increasing BMD, muscle strength and functional ability in children with hemophilia.Keywords: Hemophilia; Resistance; Aerobic exercise; Bone mineral density; Strength; Functional abilit

Inter-hemispheric EEG coherence analysis in Parkinson's disease : Assessing brain activity during emotion processing

Parkinson’s disease (PD) is not only characterized by its prominent motor symptoms but also associated with disturbances in cognitive and emotional functioning. The objective of the present study was to investigate the influence of emotion processing on inter-hemispheric electroencephalography (EEG) coherence in PD. Multimodal emotional stimuli (happiness, sadness, fear, anger, surprise, and disgust) were presented to 20 PD patients and 30 age-, education level-, and gender-matched healthy controls (HC) while EEG was recorded. Inter-hemispheric coherence was computed from seven homologous EEG electrode pairs (AF3–AF4, F7–F8, F3–F4, FC5–FC6, T7–T8, P7–P8, and O1–O2) for delta, theta, alpha, beta, and gamma frequency bands. In addition, subjective ratings were obtained for a representative of emotional stimuli. Interhemispherically, PD patients showed significantly lower coherence in theta, alpha, beta, and gamma frequency bands than HC during emotion processing. No significant changes were found in the delta frequency band coherence. We also found that PD patients were more impaired in recognizing negative emotions (sadness, fear, anger, and disgust) than relatively positive emotions (happiness and surprise). Behaviorally, PD patients did not show impairment in emotion recognition as measured by subjective ratings. These findings suggest that PD patients may have an impairment of inter-hemispheric functional connectivity (i.e., a decline in cortical connectivity) during emotion processing. This study may increase the awareness of EEG emotional response studies in clinical practice to uncover potential neurophysiologic abnormalities

Host candidate gene polymorphisms and clearance of drug-resistant parasites

Resistance to anti-malarial drugs is a widespread problem for control programmes for this devastating disease. Molecular tests are available for many anti-malarial drugs and are useful tools for the surveillance of drug resistance. However, the correlation of treatment outcome and molecular tests with particular parasite markers is not perfect, due in part to individuals who are able to clear genotypically drug-resistant parasites. This study aimed to identify molecular markers in the human genome that correlate with the clearance of malaria parasites after drug treatment, despite the drug resistance profile of the protozoan as predicted by molecular approaches

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

BACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetic nephropathy. We assessed whether epigenetic modification of DNA methylation is associated with diabetic nephropathy in a case-control study of 192 Irish patients with type 1 diabetes mellitus (T1D). Cases had T1D and nephropathy whereas controls had T1D but no evidence of renal disease. METHODS: We performed DNA methylation profiling in bisulphite converted DNA from cases and controls using the recently developed Illumina Infinium(R) HumanMethylation27 BeadChip, that enables the direct investigation of 27,578 individual cytosines at CpG loci throughout the genome, which are focused on the promoter regions of 14,495 genes. RESULTS: Singular Value Decomposition (SVD) analysis indicated that significant components of DNA methylation variation correlated with patient age, time to onset of diabetic nephropathy, and sex. Adjusting for confounding factors using multivariate Cox-regression analyses, and with a false discovery rate (FDR) of 0.05, we observed 19 CpG sites that demonstrated correlations with time to development of diabetic nephropathy. Of note, this included one CpG site located 18 bp upstream of the transcription start site of UNC13B, a gene in which the first intronic SNP rs13293564 has recently been reported to be associated with diabetic nephropathy. CONCLUSION: This high throughput platform was able to successfully interrogate the methylation state of individual cytosines and identified 19 prospective CpG sites associated with risk of diabetic nephropathy. These differences in DNA methylation are worthy of further follow-up in replication studies using larger cohorts of diabetic patients with and without nephropathy