The Invariance Hypothesis Implies Domain-Specific Regions in Visual Cortex

Is visual cortex made up of general-purpose information processing machinery, or does it consist of a collection of specialized modules? If prior knowledge, acquired from learning a set of objects is only transferable to new objects that share properties with the old, then the recognition system’s optimal organization must be one containing specialized modules for different object classes. Our analysis starts from a premise we call the invariance hypothesis: that the computational goal of the ventral stream is to compute an invariant-to-transformations and discriminative signature for recognition. The key condition enabling approximate transfer of invariance without sacrificing discriminability turns out to be that the learned and novel objects transform similarly. This implies that the optimal recognition system must contain subsystems trained only with data from similarly-transforming objects and suggests a novel interpretation of domain-specific regions like the fusiform face area (FFA). Furthermore, we can define an index of transformation-compatibility, computable from videos, that can be combined with information about the statistics of natural vision to yield predictions for which object categories ought to have domain-specific regions in agreement with the available data. The result is a unifying account linking the large literature on view-based recognition with the wealth of experimental evidence concerning domain-specific regions.National Science Foundation (U.S.). Science and Technology Center (Award CCF-1231216)National Science Foundation (U.S.) (Grant NSF-0640097)National Science Foundation (U.S.) (Grant NSF-0827427)United States. Air Force Office of Scientific Research (Grant FA8650-05-C-7262)Eugene McDermott Foundatio

Acute wound management: revisiting the approach to assessment, irrigation, and closure considerations

Abstract Background As millions of emergency department (ED) visits each year include wound care, emergency care providers must remain experts in acute wound management. The variety of acute wounds presenting to the ED challenge the physician to select the most appropriate management to facilitate healing. A complete wound history along with anatomic and specific medical considerations for each patient provides the basis of decision making for wound management. It is essential to apply an evidence‐based approach and consider each wound individually in order to create the optimal conditions for wound healing. Aims A comprehensive evidence‐based approach to acute wound management is an essential skill set for any emergency physician or acute care practitioner. This review provides an overview of current evidence and addresses frequent pitfalls. Methods A systematic review of the literature for acute wound management was performed. Results A structured MEDLINE search was performed regarding acute wound management including established wound care guidelines. The data obtained provided the framework for evidence‐based recommendations and current best practices for wound care. Conclusion Acute wound management varies based on the wound location and characteristics. No single approach can be applied to all wounds; however, a systematic approach to acute wound care integrated with current best practices provides the framework for exceptional wound management

Facilitating Next-Generation Pre-Exposure Prophylaxis Clinical Trials Using HIV Recent Infection Assays: A Consensus Statement from the Forum HIV Prevention Trial Design Project

Standard-of-care HIV pre-exposure prophylaxis (PrEP) is highly efficacious, but uptake of and persistence on a daily oral pill is low in many settings. Evaluation of alternate PrEP products will require innovation to avoid the unpractically large sample sizes in noninferiority trials. We propose estimating HIV incidence in people not on PrEP as an external counterfactual to which on-PrEP incidence in trial subjects can be compared. HIV recent infection testing algorithms (RITAs), such as the limiting antigen avidity assay plus viral load used on specimens from untreated HIV positive people identified during screening, is one possible approach. Its feasibility is partly dependent on the sample size needed to ensure adequate power, which is impacted by RITA performance, the number of recent infections identified, the expected efficacy of the intervention, and other factors. Screening sample sizes to support detection of an 80% reduction in incidence for 3 key populations are more modest, and comparable to the number of participants in recent phase III PrEP trials. Sample sizes would be significantly larger in populations with lower incidence, where the false recency rate is higher or if PrEP efficacy is expected to be lower. Our proposed counterfactual approach appears to be feasible, offers high statistical power, and is nearly contemporaneous with the on-PrEP population. It will be important to monitor the performance of this approach during new product development for HIV prevention. If successful, it could be a model for preventive HIV vaccines and prevention of other infectious diseases

The relative salience of facial features when differentiating faces based on an interference paradigm

Research on face recognition and social judgment usually addresses the manipulation of facial features (eyes, nose, mouth, etc.). Using a procedure based on a Stroop-like task, Montepare and Opeyo (J Nonverbal Behav 26(1):43-59, 2002) established a hierarchy of the relative salience of cues based on facial attributes when differentiating faces. Using the same perceptual interference task, we established a hierarchy of facial features. Twenty-three participants (13 men and 10 women) volunteered for the experiment to compare pairs of frontal faces. The participants had to judge if the eyes, nose, mouth and chin in the pair of images were the same or different. The factors manipulated were the target-distractive factor (4 face components 9 3 distractive factors), interference (absent vs. present) and correct answer (the same vs. different). The analysis of reaction times and errors showed that the eyes and mouth were processed before the chin and nose, thus highlighting the critical importance of the eyes and mouth, as shown by previous research

Machine vision for counting fruit on mango tree canopies

Machine vision technologies hold the promise of enabling rapid and accurate fruit crop yield predictions in the field. The key to fulfilling this promise is accurate segmentation and detection of fruit in images of tree canopies. This paper proposes two new methods for automated counting of fruit in images of mango tree canopies, one using texture-based dense segmentation and one using shape-based fruit detection, and compares the use of these methods relative to existing techniques:—(i) a method based on K-nearest neighbour pixel classification and contour segmentation, and (ii) a method based on super-pixel over-segmentation and classification using support vector machines. The robustness of each algorithm was tested on multiple sets of images of mango trees acquired over a period of 3 years. These image sets were acquired under varying conditions (light and exposure), distance to the tree, average number of fruit on the tree, orchard and season. For images collected under the same conditions as the calibration images, estimated fruit numbers were within 16 % of actual fruit numbers, and the F1 measure of detection performance was above 0.68 for these methods. Results were poorer when models were used for estimating fruit numbers in trees of different canopy shape and when different imaging conditions were used. For fruit-background segmentation, K-nearest neighbour pixel classification based on colour and smoothness or pixel classification based on super-pixel over-segmentation, clustering of dense scale invariant feature transform features into visual words and bag-of-visual-word super-pixel classification using support vector machines was more effective than simple contrast and colour based segmentation. Pixel classification was best followed by fruit detection using an elliptical shape model or blob detection using colour filtering and morphological image processing techniques. Method results were also compared using precision–recall plots. Imaging at night under artificial illumination with careful attention to maintaining constant illumination conditions is highly recommended. © 2016, Springer Science+Business Media New Yor

Machine vision for counting fruit on mango tree canopies

Machine vision technologies hold the promise of enabling rapid and accurate fruit crop yield predictions in the field. The key to fulfilling this promise is accurate segmentation and detection of fruit in images of tree canopies. This paper proposes two new methods for automated counting of fruit in images of mango tree canopies, one using texture-based dense segmentation and one using shape-based fruit detection, and compares the use of these methods relative to existing techniques:—(i) a method based on K-nearest neighbour pixel classification and contour segmentation, and (ii) a method based on super-pixel over-segmentation and classification using support vector machines. The robustness of each algorithm was tested on multiple sets of images of mango trees acquired over a period of 3 years. These image sets were acquired under varying conditions (light and exposure), distance to the tree, average number of fruit on the tree, orchard and season. For images collected under the same conditions as the calibration images, estimated fruit numbers were within 16 % of actual fruit numbers, and the F1 measure of detection performance was above 0.68 for these methods. Results were poorer when models were used for estimating fruit numbers in trees of different canopy shape and when different imaging conditions were used. For fruit-background segmentation, K-nearest neighbour pixel classification based on colour and smoothness or pixel classification based on super-pixel over-segmentation, clustering of dense scale invariant feature transform features into visual words and bag-of-visual-word super-pixel classification using support vector machines was more effective than simple contrast and colour based segmentation. Pixel classification was best followed by fruit detection using an elliptical shape model or blob detection using colour filtering and morphological image processing techniques. Method results were also compared using precision–recall plots. Imaging at night under artificial illumination with careful attention to maintaining constant illumination conditions is highly recommended. © 2016, Springer Science+Business Media New Yor