Dwarfs Gobbling Dwarfs: A Stellar Tidal Stream Around NGC 4449 and Hierarchical Galaxy Formation on Small Scales

A candidate diffuse stellar substructure was previously reported in the halo of the nearby dwarf starburst galaxy NGC 4449 by Karachentsev et al. We map and analyze this feature using a unique combination of deep integrated-light images from the Black Bird 0.5-meter telescope, and high-resolution wide-field images from the 8-meter Subaru telescope, which resolve the nebulosity into a stream of red giant branch stars, and confirm its physical association with NGC 4449. The properties of the stream imply a massive dwarf spheroidal progenitor, which after complete disruption will deposit an amount of stellar mass that is comparable to the existing stellar halo of the main galaxy. The ratio between luminosity or stellar-mass between the two galaxies is ~1:50, while the indirectly measured dynamical mass-ratio, when including dark matter, may be ~1:10-1:5. This system may thus represent a "stealth" merger, where an infalling satellite galaxy is nearly undetectable by conventional means, yet has a substantial dynamical influence on its host galaxy. This singular discovery also suggests that satellite accretion can play a significant role in building up the stellar halos of low-mass galaxies, and possibly in triggering their starbursts.Comment: ApJ Letters, in press. Minor changes. 6 pages, 3 figures. A high resolution version of the paper and Subaru image are available at http://www.cosmotography.com/images/small_ngc4449.htm

Preheating by Previrialization and its Impact on Galaxy Formation

We use recent observations of the HI-mass function to constrain galaxy formation. The data conflicts with the standard model where most of the gas in a low-mass dark matter halo is assumed to settle into a disk of cold gas that is depleted by star formation and supernova-driven outflows until the disk becomes gravitationally stable. A consistent model can be found if low-mass haloes are embedded in a preheated medium, with a specific gas entropy ~ 10Kev cm^2. Such a model simultaneously matches the faint-end slope of the galaxy luminosity function. We propose a preheating model where the medium around low-mass haloes is preheated by gravitational pancaking. Since gravitational tidal fields suppress the formation of low-mass haloes while promoting that of pancakes, the formation of massive pancakes precedes that of the low-mass haloes within them. We demonstrate that the progenitors of present-day dark matter haloes with M<10^{12}h^{-1}\msun were embedded in pancakes of masses ~5x10^{12}h^{-1}\msun at z~2. The formation of such pancakes heats the gas to a temperature of 5x10^5K and compresses it to an overdensity of ~10. Such gas has a cooling time that exceeds the age of the Universe at z~2, and has a specific entropy of ~15Kev cm^2, almost exactly the amount required to explain the stellar and HI mass functions. (Abridged)Comment: 13 pages, 3 figures. Accepted for publication in MNRA

Thin discs, thick dwarfs and the effects of stellar feedback

We investigate the role of stellar mass in shaping the intrinsic thickness of galaxy discs by determining the probability distribution of apparent axis ratios (b/a) for two different samples that probe the faint end of the galaxy luminosity function. We find that the b/a distribution has a characteristic 'U-shape' and identify a limiting mass M_* ~ 2x10^9 M_sun below which low-mass galaxies start to be systematically thicker. This tendency holds for very faint (M_B ~ -8) dwarfs in the Local Volume, which are essentially spheroidal systems. We argue that galaxy shape is the result of the complex interplay between mass, specific angular momentum and stellar feedback effects. Thus, the increasing importance of turbulent motions in lower mass galaxies leads to the formation of thicker systems, a result supported by the latest hydrodynamical simulations of dwarf galaxy formation and other theoretical expectations. We discuss several implications of this finding, including the formation of bars in faint galaxies, the deprojection of HI line profiles and simulations of environmental effects on the dwarf galaxy population.Comment: 6 pages, 2 figures. Accepted for publication in MNRAS Letter

On the morphologies, gas fractions, and star formation rates of small galaxies

We use a series of N-body/smoothed particle hydrodynamics simulations and analytic arguments to show that the presence of an effective temperature floor in the interstellar medium at T_F ~ 10^4 K naturally explains the tendency for low-mass galaxies to be more spheroidal, more gas rich, and less efficient in converting baryons into stars than larger galaxies. The trend arises because gas pressure support becomes important compared to angular momentum support in small dark matter haloes. We suggest that dwarf galaxies with rotational velocities ~ 40 km/s do not originate as thin discs, but rather are born as thick, puffy systems. If accreted on to larger haloes, tenuous dwarfs of this kind will be more susceptible to gas loss or tidal transformation than scaled-down versions of larger spirals. For a constant temperature floor, pressure support becomes less important in large haloes, and this produces a tendency for massive isolated galaxies to have thinner discs and more efficient star formation than their less massive counterparts, as observed.Comment: 10 pages, 8 figures, MNRAS in press. Minor changes in response to referee comment

The Resolved Structure and Dynamics of an Isolated Dwarf Galaxy: A VLT and Keck Spectroscopic Survey of WLM

We present spectroscopic data for 180 red giant branch stars in the isolated dwarf irregular galaxy WLM. Observations of the Calcium II triplet lines in spectra of RGB stars covering the entire galaxy were obtained with FORS2 at the VLT and DEIMOS on Keck II allowing us to derive velocities, metallicities, and ages for the stars. With accompanying photometric and radio data we have measured the structural parameters of the stellar and gaseous populations over the full galaxy. The stellar populations show an intrinsically thick configuration with $0.39 \leq q_{0} \leq 0.57$. The stellar rotation in WLM is measured to be $17 \pm 1$ km s$^{-1}$, however the ratio of rotation to pressure support for the stars is $V/\sigma \sim 1$, in contrast to the gas whose ratio is seven times larger. This, along with the structural data and alignment of the kinematic and photometric axes, suggests we are viewing WLM as a highly inclined oblate spheroid. Stellar rotation curves, corrected for asymmetric drift, are used to compute a dynamical mass of $4.3\pm 0.3\times10^{8}$M$_{\odot}$ at the half light radius ($r_{h} = 1656 \pm 49$ pc). The stellar velocity dispersion increases with stellar age in a manner consistent with giant molecular cloud and substructure interactions producing the heating in WLM. Coupled with WLM's isolation, this suggests that the extended vertical structure of its stellar and gaseous components and increase in stellar velocity dispersion with age are due to internal feedback, rather than tidally driven evolution. These represent some of the first observational results from an isolated Local Group dwarf galaxy which can offer important constraints on how strongly internal feedback and secular processes modulate SF and dynamical evolution in low mass isolated objects.Comment: 14 Pages, 17 figures, 3 tables. Accepted for publication in Ap

A Comprehensive Workflow for General-Purpose Neural Modeling with Highly Configurable Neuromorphic Hardware Systems

In this paper we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware-experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results

Properties of Galaxies in and around Voids

Two surveys for intrinsically faint galaxies towards nearby voids have been conducted at the MPI f\"ur Astronomie, Heidelberg. One selected targets from a new diameter limited ($\Phi \ge 5''$) catalog with morphological criteria while the other used digitized objective prism Schmidt plates to select mainly HII dwarf galaxies. For some 450 galaxies, redshifts and other optical data were obtained. We studied the spatial distribution of the sample objects, their luminosity function, and their intrinsic properties. Most of the galaxies belong to already well known sheets and filaments. But we found about a dozen highly isolated galaxies in each sample (nearest neighborhood distance $\ge 3 h_{75}^{-1} Mpc$). These tend to populate additional structures and are not distributed homogeneously throughout the voids. As our results on 'void galaxies' still suffer from small sample statistics, I also tried to combine similar existing surveys of nearby voids to get further hints on the larger structure and on the luminosity function of the isolated galaxies. No differences in the luminosity function of sheet and void galaxies could be found. The optical and infrared properties of both samples are in the normal range for samples dominated by late-type dwarfs. Follow-up HI studies show that the isolated dwarfs in both samples have unusual high amount of neutral gas for a given luminosity.Comment: 10 pages, 4 figures, latex, to appear in the proceedings of the 'Ringberg workshop on Large Scale Structure', hold Sep. 23-28, 199

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. METHODS Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. RESULTS Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). CONCLUSION Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

The origin of the light distribution in spiral galaxies

We analyse a high-resolution, fully cosmological, hydrodynamical disc galaxy simulation, to study the source of the double-exponential light profiles seen in many stellar discs, and the effects of stellar radial migration upon the spatiotemporal evolution of both the disc age and metallicity distributions. We find a ‘break’ in the pure exponential stellar surface brightness profile, and trace its origin to a sharp decrease in the star formation per unit surface area, itself produced by a decrease in the gas volume density due to a warping of the gas disc. Star formation in the disc continues well beyond the break. We find that the break is more pronounced in bluer wavebands. By contrast, we find little or no break in the mass density profile. This is, in part, due to the net radial migration of stars towards the external parts of the disc. Beyond the break radius, we find that ∼60 per cent of the resident stars migrated from the inner disc, while ∼25 per cent formed in situ. Our simulated galaxy also has a minimum in the age profile at the break radius but, in disagreement with some previous studies, migration is not the main mechanism producing this shape. In our simulation, the disc metallicity gradient flattens with time, consistent with an ‘inside-out’ formation scenario. We do not find any difference in the intensity or the position of the break with inclination, suggesting that perhaps the differences found in empirical studies are driven by dust extinction