Brexit: What next? Sovereignty, Devolution, and Economic Policy – an open forum

Wednesday, 12 October 2016 Time: 5.15pm to 6.45pm Location: Maurice Keyworth Building SR (1.09) Leeds University Business Schoo

Studies on the Synthesis, Stability and Conformation of 2-Sulfonyl-Oxetane Fragments

A library of 2-sulfonyl oxetane fragments has been synthesised and elaborated into lead-like compounds. The oxetane derivatives were stable to acidic and basic conditions and have 3-preferred conformations.</p

Realist econometrics? Nell and Errouaki on methodological institutionalism, regularity and uncertainty

Nell and Errouaki state that their intent is to reformulate econometrics along more realistic lines. In so doing they also explicitly acknowledge a debt to realist debates in methodology, notably in relation to the construction of argument regarding the nature of science, objectivity and laws in Chapter 4 (Nell and Errouaki, 2013: xii). This requires some context, since seeking to be more realistic and accepting the tenets of realism are not necessarily the same. One is theory and application, and the other is argument regarding the grounds of theory and application. Moreover, the status of econometrics in relation to realism is not an uncontroversial subject. Nell and Errouaki’s work is worth careful consideration because its themes are so little considered within econometrics, despite their relevance for the role and realisticness of econometrics. The vast majority of work on econometrics concerns problems of method only – the technical limits of methods and resolutions to technical problems – very little of it concerns how (and whether) an econometric inquiry should be structured and pursued in order to be adequate

Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells.

The HOX genes encode a family of transcription factors that are dysregulated in several malignancies and have been implicated in oncogenesis and cancer cell survival. Disruption of HOX protein function using the peptide HXR9 has shown anti-tumor effects against melanoma, lung cancer and renal cancer. In this report, we evaluated the expression of all 39 HOX genes in a panel of six malignant B-cell lines, including multiple myeloma cells and found different levels of expression of HOX family members suggesting that they also have a role in malignant B-cell survival. We show that disrupting HOX function using the peptide HXR9 induces significant cytotoxicity in the entire panel of cell lines. Importantly, we found that the cytotoxic effects of HXR9 can be enhanced by combining it with ch128.1Av, an antibody-avidin fusion protein specific for the human transferrin receptor 1 (CD71). Iron starvation induced by the fusion protein contributes to the enhanced effect and involves, at least in part, the induction of a caspase-independent pathway. These results show the relevance of HOX proteins in malignant B-cell survival and suggest that our therapeutic strategy may be effective in the treatment of incurable B-cell malignancies such as multiple myeloma