The Computer Misuse Act 1990: lessons from its past and predictions for its future

The age of the internet has thrown down some real challenges to the Computer Misuse Act 1990. Recently, the Government made changes to this piece of legislation, in an attempt to meet two of those challenges--the proliferation of “ Denial of Service” (DoS) attacks, and the creation and dissemination of “ Hackers' tools” --and to fulfil international commitments on cybercrime. Yet some of these new measures invite criticisms of policy, form and content, and bring doubts about how easy to interpret, and how enforceable, they will be

The Meaning of Poverty: Questions of Distribution and Power

Focusing on the low-income parts of the world and reviewing the different ways we can define poverty, I first argue that what people generally mean by poverty – or, more broadly, by economic well-being – cannot be adequately captured by a single, absolute measure such as income level or a more complex aggregate such as the Human Development Index. Not only do these measures fail to account for the complexity of human material needs, but they also fail to recognize the importance of distributional issues. The failure to incorporate a consideration of distribution in defining poverty is conceptually problematic, if not simply wrong. This failure also creates serious practical problems for campaigns against poverty, at best limiting their impact and at worst dooming them to failure. The United Nations Millennium Goals program is a case in point. If poverty is viewed simply in absolute terms rather than including a consideration of distributional issues, the social structures that generate poverty tend to be ignored. Policy is then viewed as a technical issue and often focuses on particular programs that are directed to helping the poor improve their absolute situation: new seed varieties to raise income, mosquito nets treated with insecticide to improve health, more schools to raise the level of education. These sorts of policies, when they are actually implemented successfully, can have positive impacts. Yet they leave unexamined and unaddressed the social structures and power relations that have generated and continue to generate poverty.poverty, income distribution, power, Millennium Development Goals, Human Devleopment Index

Why Equality? How Equality?

Much of the discussion of economic development in low and middle income countries and of poverty reduction has either ignored the issue of income distribution or has tended to view income distribution only in terms of its impact on economic growth. In this paper I argue that such an approach is misguided.development, distribution, poverty

Climate Change, Markets, and Technology

Environmental Economics and Policy, Resource /Energy Economics and Policy, Q15, Q25, Q38,

Stalking Victims, Victims of Sexual Violence and Criminal Justice System Responses: Is there a Difference or just ‘Business as Usual’?

Based on the qualitative accounts of 26 self-defined stalking victims, this article examines the experiences of stalking victims with regard to the responses they received from criminal justice system practitioners. These experiences are compared and discussed in relation to the responses victims of domestic violence and rape commonly receive by criminal justice system officials. The discussion reveals the way the experiences of stalking victims with criminal justice system officials parallel the experiences of victims of other forms of sexual violence and points out the meaning of these commonalities. The article concludes by assessing the role of the law in improving the treatment of victims by the criminal justice system and problematizing its potential in bringing about social change

Liberalization, migration and development : the Mexico-U.S. relationship

Las migraciones desde México a EE.UU. han aumentado por la liberalización de la economía mexicana. Los defensores de la liberalización habían mantenido que ésta reduciría las migraciones; de hecho, usaban tal argumento junto con el sentir anti-inmigrantes como base para hacer atractivo al público estadounidense el Tratado de Libre Comercio de América del Norte. La demagogia anti-inmigración no sólo era ofensiva sino errónea en cuanto a su contenido. Diversos efectos de la liberalización han actuado como factores causales de los movimientos de personas hacia el Norte y del mantenimiento de altas tasas de migración. Esta realidad debería forzar una re-evaluación de las políticas en EE.UU. Una política que aceptara la realidad de las continuas migraciones y que integrara a los inmigrantes a la fuerza de trabajo con derechos plenos podría tener amplios beneficios. ___________________________________Migration from Mexico to the United States has been increased by liberalization of the Mexican economy. Proponents of liberalization had maintained that it would reduce migration; indeed, they used this argument along with anti-immigrant sentiment as one basis on which to sell the North American Free Trade Agreement to the U.S. public. The anti-immigration demagogy was not only offensive in sentiment but also wrong in substance. Various impacts of liberalization have been causal factors moving people northward and maintaining the high rate of migration. This reality should force a reassessment of policy in the United States. A policy that accepted the reality of continuing migration and integrated the immigrants into the labor force with full rights could have widespread benefits

Interfacing peripheral nerve with macro-sieve electrodes following spinal cord injury

Macro-sieve electrodes were implanted in the sciatic nerve of five adult male Lewis rats following spinal cord injury to assess the ability of the macro-sieve electrode to interface regenerated peripheral nerve fibers post-spinal cord injury. Each spinal cord injury was performed via right lateral hemisection of the cord at the T9–10 site. Five months post-implantation, the ability of the macro-sieve electrode to interface the regenerated nerve was assessed by stimulating through the macro-sieve electrode and recording both electromyography signals and evoked muscle force from distal musculature. Electromyography measurements were recorded from the tibialis anterior and gastrocnemius muscles, while evoked muscle force measurements were recorded from the tibialis anterior, extensor digitorum longus, and gastrocnemius muscles. The macro-sieve electrode and regenerated sciatic nerve were then explanted for histological evaluation. Successful sciatic nerve regeneration across the macro-sieve electrode interface following spinal cord injury was seen in all five animals. Recorded electromyography signals and muscle force recordings obtained through macro-sieve electrode stimulation confirm the ability of the macro-sieve electrode to successfully recruit distal musculature in this injury model. Taken together, these results demonstrate the macro-sieve electrode as a viable interface for peripheral nerve stimulation in the context of spinal cord injury

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

Phosphoinositide-3-kinase (PI3K) is an enzyme group, known to regulate key survival pathways in acute myeloid leukaemia (AML). It generates phosphatidylinositol-3,4,5-triphosphate, which provides a membrane docking site for protein kinaseB activation. PI3K catalytic p110 subunits are divided into 4 isoforms; α,β,δ and γ. The PI3Kδ isoform is always expressed in AML cells, whereas the frequency of PI3Kγ expression is highly variable. The functions of these individual catalytic enzymes have not been fully resolved in AML, therefore using the PI3K p110δ and p110γ-targeted inhibitor IPI-145 (duvelisib) and specific p110δ and p110γ shRNA, we analysed the role of these two p110 subunits in human AML blast survival. The results show that PI3Kδ and PI3Kγ inhibition with IPI-145 has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with IPI-145 inhibits both adhesion and migration of AML blasts to bone marrow stromal cells. Using shRNA targeted to the individual isoforms we demonstrated that p110δ-knockdown had a more significant anti-proliferative effect on AML cells, whereas targeting p110γ-knockdown significantly inhibited AML migration. The results demonstrate that targeting both PI3Kδ and PI3Kγ to inhibit AML-BMSC interactions provides a biologic rationale for the pre-clinical evaluation of IPI-145 in AML

Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML

Pharmacological targeting of BTK using ibrutinib has recently shown encouraging clinical activity in a range of lymphoid malignancies. Recently we reported that ibrutinib inhibits human acute myeloid leukemia (AML) blast proliferation and leukemic cell adhesion to the surrounding bone marrow stroma cells. Here we report that in human AML ibrutinib, in addition, functions to inhibit SDF1/CXCR4-mediated AML migration at concentrations achievable in vivo. It has previously been shown that SDF1/CXCR4-induced migration is dependent on activation of downstream BTK in chronic lymphocytic leukaemia (CLL) and multiple myeloma. Here we show that SDF-1 induces BTK phosphorylation and downstream MAPK signalling in primary AML blast. Furthermore, we show that ibrutinib can inhibit SDF1-induced AKT and MAPK activation. These results reported here provide a molecular mechanistic rationale for clinically evaluating BTK inhibition in AML patients and suggests that in some AML patients the blasts count may initially rise in response to ibrutinib therapy, analgous to similar clinical observations in CLL