‘We are labeled as gang members, even though we are not’: belonging, aspirations and social mobility in Cartagena

This paper explores how belonging and aspirations interact to shape marginalized young Colombians’ strategies for upward social mobility. Recent literature has argued that in the context of inequality and poverty, social mobility is constrained by people’s inability to aspire to and/or achieve their aspirations. The majority of this literature is from the economics field and looks at the way poverty acts as a brake on social mobility. This paper provides an additional interdisciplinary analysis of the role of ‘belonging’ (to places and social class) in influencing aspirations of young Colombians. Findings are based on ethnographic fieldwork with young people from two marginalized neighborhoods in Cartagena. It is argued that aspirations are closely linked to belonging and the extent to which young people feel integral to or distanced from their localities. Using a Bourdieusian perspective, the paper examines how belonging is developed and how it influences behavior, orientations and future prospects. This approach generates insights into young people’s apparent low aspirations beyond the explanation of internal behavioral poverty traps. In so doing, it provides a more comprehensive understanding of how societal structures limit aspiration development and achievement

Systematic Management of Stocking Rates Improves Performance of Northern Australian Cattle Properties in a Variable Climate

The risks for extensive cattle properties in the rangelands of northern Australia arising from high inter-annual rainfall variability are predominantly managed through adjustments in stocking rates (SR). This modelling study compared the performance of SR strategies that varied considerably in the extent that they adjusted SR annually at three locations in northern Australia. At all locations, land types and pasture condition states, the SR strategies that achieved the best pasture condition were those that least increased and most decreased SR annually in response to changes in forage availability. At Donors Hill (Qld), these conservative strategies also achieved the highest cattle live-weight gains per hectare (LWG/ha). While conservative strategies produced the highest percent perennials at Fitzroy Crossing (WA), strategies which allowed larger increases and decreases in SR also performed well, enabling them to also achieve high LWG/ha with little deterioration of pasture condition. A similar trend occurred at Alice Springs (NT), although at this location the strategies with even larger annual increases and decreases in SR achieved relatively high percent perennials and the highest LWG/ha. While systematic management of SR appears to perform better than a constant SR strategy when rainfall variability is high, it is unclear if the magnitude of annual adjustments in SR needs to increase with increasing rainfall variability

Identifying and Addressing Sustainable Pasture and Grazing Management Options for a Major Economic Sector–The North Australian Beef Industry

Sustainable use of the northern grazing lands is a long-standing issue for management and policy, heightened by projections of increased climatic variability, uncertainty on forage supplies, vegetation complexes, and weeds and diseases. Meat and Livestock Australia has supported a large study to explore sustainable grazing management strategies and increase the capacity of the sector to address climate change. Potential options were explored by bio-economic modeling of ‘representative’ beef enterprises defined by pastoralists and supported by regional research and extension specialists. Typical options include diversification, infrastructure, flexible stocking rates, wet season resting, and prescribed fire. Concurrent activities by another team included regional impact assessments and surveys of pastoralists’ understanding and attitudes towards climate change and adaptive capacity. The results have been widely canvassed and a program of on-ground demonstrations of various options implemented. The paper describes the structure of this program and highlights key results indicating considerable scope to address sustainability challenges

Impacts of Projected Climate Change on Pasture Growth and Safe Carrying Capacities for Three Extensive Grazing Land Regions in Northern Australia

The northern beef industry is a major component of the regional economies of Queensland, Northern Territory and northern Western Australia, and has contributed an estimated $5 billion to Australia’s economy in 2009-10. Projected climate change will have an adverse impact on Australia’s agricultural production (McKeon et al. 2008) with an expected 3.5% decline in beef production in northern Australia by 2030 (Heyhoe et al. 2008). The GRASP pasture production model (McKeon et al. 2000) has been used to evaluate impacts of climate change in Australia’s rangelands (Crimp et al. 2002, McKeon et al. 2008), with the positive effects of higher carbon dioxide (CO2) on pasture growth likely to be offset by reductions in pasture productivity and digestibility due to lower rainfall and higher temperatures (Crimp et al. 2002). The impacts of three projected future climates on livestock carrying capacity of grazing lands in Fitzroy, Maranoa-Balonne and Victoria River District regions were assessed using GRASP

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Municipal-academic partnerships for innovation in sanitation delivery: a case study in Durban, South Africa

Service delivery for the diverse communities of eThekwini Municipality requires innovative solutions. The partnership between the Pollution Research Group (PRG) at the University of KwaZulu-Natal (UKZN) and eThekwini Water and Sanitation (EWS) began informally in the 1960s and was first formalised in 2006. The Memorandum of Agreement (MoA) between the two organisations included a retainer that allowed greatly flexibility than would have been possible with project-to-project funding. This allows the PRG to act as an in-house research and development team for EWS and gives the PRG access to numerous research sites. The partnership has led to global recognition for progressive policies and innovative service delivery. It has benefited from interdisciplinary research, trust between organisations and individuals that is built on open and transparent communication, and strong leadership. EWS and the PRG are keen to support similar municipal-academic partnerships across Africa to support locally relevant applied sanitation research

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors

A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The nonreceptor tyrosine kinase SRC regulates many cellular signalling processes, and pharmacological inhibition has long been a target of cancer drug discovery projects. Here, we describe the in vitro and in vivo characterisation of the small‐molecule SRC inhibitor AZD0424. We show that AZD0424 potently inhibits the phosphorylation of tyrosine‐419 of SRC (IC50 ~ 100 nm) in many cancer cell lines; however, inhibition of cell viability, via a G1 cell cycle arrest, was observed only in a subset of cancer cell lines in the low (on target) micromolar range. We profiled the changes in intracellular pathway signalling in cancer cells following exposure to AZD0424 and other targeted therapies using reverse‐phase protein array (RPPA) analysis. We demonstrate that SRC is activated in response to treatment of KRAS‐mutant colorectal cell lines with MEK inhibitors (trametinib or AZD6244) and that AZD0424 abrogates this. Cell lines treated with trametinib or AZD6244 in combination with AZD0424 had reduced EGFR, FAK and SRC compensatory activation, and cell viability was synergistically inhibited. In vivo, trametinib treatment of mice‐bearing HCT116 tumours increased phosphorylation of SRC on Tyr419, and, when combined with AZD0424, inhibition of tumour growth was greater than with trametinib alone. We also demonstrate that drug‐induced resistance to trametinib is not re‐sensitised by AZD0424 treatment in vitro, likely as a result of multiple compensatory signalling mechanisms; however, inhibition of SRC remains an effective way to block invasion of trametinib‐resistant tumour cells. These data imply that SRC inhibition may offer a useful addition to MEK inhibitor combination strategies

Resting pastures to improve land condition in northern Australia: guidelines based on the literature and simulation modelling

Pasture rest is a possible strategy for improving land condition in the extensive grazing lands of northern Australia. If pastures currently in poor condition could be improved, then overall animal productivity and the sustainability of grazing could be increased. The scientific literature is examined to assess the strength of the experimental information to support and guide the use of pasture rest, and simulation modelling is undertaken to extend this information to a broader range of resting practices, growing conditions and initial pasture condition. From this, guidelines are developed that can be applied in the management of northern Australia’s grazing lands and also serve as hypotheses for further field experiments. The literature on pasture rest is diverse but there is a paucity of data from much of northern Australia as most experiments have been conducted in southern and central parts of Queensland. Despite this, the limited experimental information and the results from modelling were used to formulate the following guidelines. Rest during the growing season gives the most rapid improvement in the proportion of perennial grasses in pastures; rest during the dormant winter period is ineffective in increasing perennial grasses in a pasture but may have other benefits. Appropriate stocking rates are essential to gain the greatest benefit from rest: if stocking rates are too high, then pasture rest will not lead to improvement; if stocking rates are low, pastures will tend to improve without rest. The lower the initial percentage of perennial grasses, the more frequent the rests should be to give a major improvement within a reasonable management timeframe. Conditions during the growing season also have an impact on responses with the greatest improvement likely to be in years of good growing conditions. The duration and frequency of rest periods can be combined into a single value expressed as the proportion of time during which resting occurs; when this is done the modelling suggests the greater the proportion of time that a pasture is rested, the greater is the improvement but this needs to be tested experimentally. These guidelines should assist land managers to use pasture resting but the challenge remains to integrate pasture rest with other pasture and animal management practices at the whole-property scale

Resting pastures to improve land condition in northern Australia: guidelines based on the literature and simulation modelling

Pasture rest is a possible strategy for improving land condition in the extensive grazing lands of northern Australia. If pastures currently in poor condition could be improved, then overall animal productivity and the sustainability of grazing could be increased. The scientific literature is examined to assess the strength of the experimental information to support and guide the use of pasture rest, and simulation modelling is undertaken to extend this information to a broader range of resting practices, growing conditions and initial pasture condition. From this, guidelines are developed that can be applied in the management of northern Australia’s grazing lands and also serve as hypotheses for further field experiments. The literature on pasture rest is diverse but there is a paucity of data from much of northern Australia as most experiments have been conducted in southern and central parts of Queensland. Despite this, the limited experimental information and the results from modelling were used to formulate the following guidelines. Rest during the growing season gives the most rapid improvement in the proportion of perennial grasses in pastures; rest during the dormant winter period is ineffective in increasing perennial grasses in a pasture but may have other benefits. Appropriate stocking rates are essential to gain the greatest benefit from rest: if stocking rates are too high, then pasture rest will not lead to improvement; if stocking rates are low, pastures will tend to improve without rest. The lower the initial percentage of perennial grasses, the more frequent the rests should be to give a major improvement within a reasonable management timeframe. Conditions during the growing season also have an impact on responses with the greatest improvement likely to be in years of good growing conditions. The duration and frequency of rest periods can be combined into a single value expressed as the proportion of time during which resting occurs; when this is done the modelling suggests the greater the proportion of time that a pasture is rested, the greater is the improvement but this needs to be tested experimentally. These guidelines should assist land managers to use pasture resting but the challenge remains to integrate pasture rest with other pasture and animal management practices at the whole-property scale