Pre-trilostane and 3-hour post-trilostane cortisol to monitor trilostane therapy in dogs

It is recommended that trilostane therapy of canine hyperadrenocorticism is monitored using an ACTH stimulation test, however this has never been validated. Three cortisol concentrations (pre-trilostane, 3-hour posttrilostane and 1-hour post-ACTH stimulation) were compared to a clinical score obtained from an owner questionnaire. There were 110 sets of 3 cortisol measurements and questionnaires obtained from 67 trilostane treated dogs. Questionnaire results were used to classify each dog as well or unwell. Well dogs were then categorised as having excellent, moderate or poor hyperadrenocorticism control, using thresholds produced by 14 independent veterinarians. Correlation co-efficients were used to compare the three cortisol concentrations to the owner score and the Kruskal Wallis and Mann-Whitney U tests were used to compare the three cortisol concentrations between categories of control. Cortisol cut-off values between significantly different categories were determined using ROC curves. Pre-trilostane and 3-hour post-trilostane cortisol were better correlated to the owner score and had cut-offs to differentiate between categories of control that had superior sensitivity and specificity results, than the post-ACTH cortisol. Iatrogenic hypoadrenocorticism was not detected in any unwell dog. This study shows that the pre-trilostane and 3-hour post-trilostane cortisol are potentially better monitoring methods than the ACTH stimulation test

On characteristic equations, trace identities and Casimir operators of simple Lie algebras

Two approaches are developed to exploit, for simple complex or compact real Lie algebras g, the information that stems from the characteristic equations of representation matrices and Casimir operators. These approaches are selected so as to be viable not only for `small' Lie algebras and suitable for treatment by computer algebra. A very large body of new results emerges in the forms, a) of identities of a tensorial nature, involving structure constants etc. of g, b) of trace identities for powers of matrices of the adjoint and defining representations of g, c) of expressions of non-primitive Casimir operators of g in terms of primitive ones. The methods are sufficiently tractable to allow not only explicit proof by hand of the non-primitive nature of the quartic Casimir of g2, f4, e6, but also e.g. of that of the tenth order Casimir of f4.Comment: 39 pages, 8 tables, late

Subduction Duration and Slab Dip

The dip angles of slabs are among the clearest characteristics of subduction zones, but the factors that control them remain obscure. Here, slab dip angles and subduction parameters, including subduction duration, the nature of the overriding plate, slab age, and convergence rate, are determined for 153 transects along subduction zones for the present day. We present a comprehensive tabulation of subduction duration based on isotopic ages of arc initiation and stratigraphic, structural, plate tectonic and seismic indicators of subduction initiation. We present two ages for subduction zones, a long‐term age and a reinitiation age. Using cross correlation and multivariate regression, we find that (1) subduction duration is the primary parameter controlling slab dips with slabs tending to have shallower dips at subduction zones that have been in existence longer; (2) the long‐term age of subduction duration better explains variation of shallow dip than reinitiation age; (3) overriding plate nature could influence shallow dip angle, where slabs below continents tend to have shallower dips; (4) slab age contributes to slab dip, with younger slabs having steeper shallow dips; and (5) the relations between slab dip and subduction parameters are depth dependent, where the ability of subduction duration and overriding plate nature to explain observed variation decreases with depth. The analysis emphasizes the importance of subduction history and the long‐term regional state of a subduction zone in determining slab dip and is consistent with mechanical models of subduction

One-dimensional radiation-hydrodynamic simulations of imploding spherical plasma liners with detailed equation-of-state modeling

This work extends the one-dimensional radiation-hydrodynamic imploding spherical argon plasma liner simulations of T. J. Awe et al. [Phys. Plasmas 18, 072705 (2011)] by using a detailed tabular equation-of-state (EOS) model, whereas Awe et al. used a polytropic EOS model. Results using the tabular EOS model give lower stagnation pressures by a factor of 3.9-8.6 and lower peak ion temperatures compared to the polytropic EOS results. Both local thermodynamic equilibrium (LTE) and non-LTE EOS models were used in this work, giving similar results on stagnation pressure. The lower stagnation pressures using a tabular EOS model are attributed to a reduction in the liner's ability to compress arising from the energy sink introduced by ionization and electron excitation, which are not accounted for in a polytropic EOS model. Variation of the plasma liner species for the same initial liner geometry, mass density, and velocity was also explored using the LTE tabular EOS model, showing that the highest stagnation pressure is achieved with the highest atomic mass species for the constraints imposed.Comment: 21 pages, 3 tables, 7 figures, accepted for publication by Phys. Plasmas (9/24/2012

Trait anxiety but not state anxiety during critical Illness was associated with anxiety and depression over 6 months after ICU

Objective: To determine the association between anxiety during critical illness and symptoms of anxiety and depression over 6 months after ICU discharge in survivors of intensive care treatment. Design: Longitudinal study. Setting: One closed mixed ICU in an adult tertiary hospital in Brisbane, Australia. Patients: Participants (n = 141) were adults (≥ 8 yr), admitted to ICU for at least 24 hours, able to communicate either verbally or nonverbally, understand English, and open their eyes spontaneously or in response to voice. Interventions: None. Measurements and Main Results: The outcomes of symptoms of anxiety and depression over 6 months after ICU discharge were assessed using the Hospital Anxiety Depression Scale. The primary variable of interest was anxiety during critical illness. Two components of anxiety (state and trait) were assessed during critical illness using the Faces Anxiety Scale and the trait component of the State-Trait Anxiety Inventory. Perceived social support, cognitive functioning, and posttraumatic stress symptoms were also assessed using standardized instruments. Clinical and demographic data were obtained from patients and medical records. Participants were followed up in hospital wards and at 3 and 6 months after ICU discharge. During ICU treatment, 81 of the 141 participants (57%) reported moderate to severe levels of state anxiety. Of the 92 participants who completed the surveys at the 6-month follow-up, 26 participants (28%) reported symptoms of anxiety and 21 (23%) symptoms of depression. Symptoms of anxiety and depression were strongly correlated in this cohort of survivors. Trait anxiety was significantly associated with both anxiety and depression symptoms over time; however, state anxiety was not associated with either outcome. Participants who reported post-ICU memories of intra-ICU anxiety were significantly more anxious during recovery over 6 months. Cognitive functioning and posttraumatic stress symptoms were both significantly associated with anxiety and depression symptoms over time. Conclusion: Symptoms of anxiety and depression are a significant issue for general ICU survivors. Trait anxiety was significantly associated with adverse emotional outcomes over 6 months after ICU discharge. There was also a significant relationship between post-ICU memories of intra-ICU anxiety and anxiety during recovery. Interventions to reduce anxiety during critical illness need to be considered and evaluated for their longer term benefits for survivors of critical illness

The role of primary healthcare professionals in oral cancer prevention and detection

AIM: To investigate current knowledge, examination habits and preventive practices of primary healthcare professionals in Scotland, with respect to oral cancer, and to determine any relevant training needs. SETTING: Primary care. METHOD: Questionnaires were sent to a random sample of 357 general medical practitioners (GMPs) and 331 dental practitioners throughout Scotland. Additionally, focus group research and interviews were conducted amongst primary healthcare team members. RESULTS: Whilst 58% of dental respondents reported examining regularly for signs of oral cancer, GMPs examined patients' mouths usually in response to a complaint of soreness. The majority of GMPs (85%) and dentists (63%) indicated that they felt less than confident in detecting oral cancer, with over 70% of GMPs identifying lack of training as an important barrier. Many practitioners were unclear concerning the relative importance of the presence of potentially malignant lesions in the oral cavity. A high proportion of the GMPs indicated that they should have a major role to play in oral cancer detection (66%) but many felt strongly that this should be primarily the remit of the dental team. CONCLUSION: The study revealed a need for continuing education programmes for primary care practitioners in oral cancer-related activities. This should aim to improve diagnostic skills and seek to increase practitioners' participation in preventive activities

Validity and normative data for thirty-second chair stand test in elderly community-dwelling Hong Kong Chinese

It is important to establish valid field measures of lower body strength in the elderly, and to provide representative normative values that are culturally specific in order to help health professionals in the risk assessment of this group. A sample of 1,038 elderly Hong Kong Chinese undertook a 30-sec chair stand test (30CST), with a subsample of 143 completing isometric measures of maximal hip flexion and knee extension, plus a habitual physical activity questionnaire. The 30CST was significantly, yet only weakly, correlated with the isometric strength measures (r ∼ 0.3-0.4), but accurately discriminated between levels of habitual physical activity and across ages in decades. The normative values generated provide useful data for health screening in this elderly Hong Kong population, but do not compare well with their healthier US counterparts. © 2006 Wiley-Liss, Inc.postprin

Patterns of physical exercise and contributing factors among Hong Kong older adults

Key Messages 1. Studies suggest that regular physical activity and exercise offer a significant opportunity to enhance years of active independent life for older individuals. However, the majority of local respondents have a relatively sedentary lifestyle and were not getting adequate physical activity and exercise, though many recognised the health benefits of being active. 2. Compared with their relatively active American counterparts, in terms of strength, flexibility and agility, the respondents of this study fared unfavourably, with mean values in the 20-30 percentile score or lower. 3. More than 80% of elderly adults regularly participated in sports activities, the majority of whom engaged in only a low-to-moderate level of physical exercise mainly due to limited choices and time allocation for such activity. Nearly 17% of the respondents engaged in walking as a leisure activity; a substantial proportion included completion of their household activities (shopping, visiting friends) in what they termed ‘walking’. As walking confers many health benefits, its promotion in the immediate environments of the elderly is practical and undoubtedly health enhancing. 4. Findings suggested that cognitive-perceptual factors, ie perceived ‘pros’ and ‘cons’ of doing exercise, selfefficacy of exercise, stages of change and perceived barriers to exercise were all influential variables contributing to engagement in sports activity. Longitudinal studies are needed to understand the causal and temporal relations between these variables. 5. Health promotion programmes to educate older adults about the benefits of engaging in physical activity with respect to their self-efficacy are crucial. Education can enhance individual’s knowledge and/or awareness concerning the health benefits of physical activity and exercise. Those who are deprived and less educated should receive more attention from policymakers and service providers.published_or_final_versio

Interference effects in f-deformed fields

We show how the introduction of an algeabric field deformation affects the interference phenomena. We also give a physical interpretation of the developed theory.Comment: 6 pages, Latex file, no figures, accepted by Physica Script