Wojenna proza Wiktora Astafiewa a problem nienawiści i przebaczenia

Viktor Astafyev was an outstanding Russian writer and a representative  of ”village prose”. In his oeuvre, along with works on the question of “man and nature”, we may find numerous important works concerning the subject of war. Astafyev fought in WWII, which left him with some unhealed wounds. In his novels about this 'Great Patriotic War', the dominating pacifist humanism triggered the first depiction of German soldiers through the prism of Christian mercy in Russian literature. The attempt to analyze the novel The Cursed and the Slain is very relevant in light of our present reality, full of news of new military conflicts, including that in eastern Ukraine

Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke.

Stroke is the leading cause of adult disability. Neurogenesis after stroke is associated with repair; however, the mechanisms regulating poststroke neurogenesis and its functional effect remain unclear. Here, we investigate multiple mechanistic routes of induced neurogenesis in the poststroke brain, using both a forelimb overuse manipulation that models a clinical neurorehabilitation paradigm, as well as local manipulation of cellular activity in the peri-infarct cortex. Increased activity in the forelimb peri-infarct cortex via either modulation drives increased subventricular zone (SVZ) progenitor proliferation, migration, and neuronal maturation in peri-infarct cortex. This effect is sensitive to competition from neighboring brain regions. By using orthogonal tract tracing and rabies virus approaches in transgenic SVZ-lineage-tracing mice, SVZ-derived neurons synaptically integrate into the peri-infarct cortex; these effects are enhanced with forelimb overuse. Synaptic transmission from these newborn SVZ-derived neurons is critical for spontaneous recovery after stroke, as tetanus neurotoxin silencing specifically of the SVZ-derived neurons disrupts the formation of these synaptic connections and hinders functional recovery after stroke. SVZ-derived neurogenesis after stroke is activity-dependent, region-specific, and sensitive to modulation, and the synaptic connections formed by these newborn cells are functionally critical for poststroke recovery

BRAFV600E mutation in cutaneous lesions of patients with adult Langerhans cell histiocytosis.

BACKGROUND: Langerhans cell histiocytosis (LCH) is characterized by the proliferation of pathologic Langerhans cells. The disease can develop in any age and can affect almost any organ. Cutaneous involvement is frequent in LCH. The recent demonstration of the activating, oncogenic BRAFV600E gene mutation in LCH samples strongly supports the neoplastic origin of the disease. OBJECTIVES: Our aim was to analyse the clinical data of the patients and whether BRAFV600E mutation is present in skin lesions of patients with adult onset LCH, and to investigate whether the BRAFV600E mutation status has any effect on the clinical presentation and the outcome of the disease. METHODS: We diagnosed and treated 15 adult LCH patients in the period of 1987-2012 and collected their clinical data. Three of our patients suffered from skin involvement and 12 patients had multiorgan disease (five patients out of the multisystem group died). Eleven formalin-fixed paraffin-embedded skin samples from 10 patients were available for BRAFV600E mutation analysis. RESULTS: Among the 11 examined samples, 6 contained the BRAFV600E mutation (54.5%). Our results indicate that in the adult group of LCH patients the presence of BRAFV600E mutation is similar to what was previously suggested in case of the childhood forms, at least as far as skin lesions are concerned. The BRAF mutation status of our patients does not seem to correlate with the extent and/or the outcome of the disease. CONCLUSION: Our results support the neoplastic origin of LCH and suggest that skin lesions of LCH are sufficient for the diagnosis of the disease and for assessing its BRAF status. In addition, analysis of BRAF status of patients with LCH can lead to the administration of new targeted therapies which may provide better disease control and prognosis

Religious and moral problems in the rural prose of the 20th century (V. Astafiev, V. Rasputin, and V. Shukshin)

Victor Astafiev, Valentin Rasputin and Vasiliy Shukshin are the representatives of a rural Russian prose. They all come from Siberia that has a great impact on their works. They wanted to save the rural spirit, hidden in the endless forests of the taiga, from the destructive influence of the urban culture. The writers wanted the Siberian countryside to help Russian society, which was drawn away from cultural roots, to return again to God.Victor Astafiev, Valentin Rasputin and Vasiliy Shukshin are the representatives of a rural Russian prose. They all come from Siberia that has a great impact on their works. They wanted to save the rural spirit, hidden in the endless forests of the taiga, from the destructive influence of the urban culture. The writers wanted the Siberian countryside to help Russian society, which was drawn away from cultural roots, to return again to God.Victor Astafiev, Valentin Rasputin and Vasiliy Shukshin are the representatives of a rural Russian prose. They all come from Siberia that has a great impact on their works. They wanted to save the rural spirit, hidden in the endless forests of the taiga, from the destructive influence of the urban culture. The writers wanted the Siberian countryside to help Russian society, which was drawn away from cultural roots, to return again to God

Sapo-boi : um sistema de detecção de instrusões por assinatura em espaços de kernel e usuário utilizando BPF e XDP

Orientador: André Ricardo Abed GrégioCoorientador: Vinicius Fulber-GarciaDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Exatas, Programa de Pós-Graduação em Informática. Defesa : Curitiba, 18/06/2025Inclui referênciasÁrea de concentração: Ciência da ComputaçãoResumo: Sistemas de Detecção de Intrusão em redes por assinatura proporcionam uma maneira de realizar inspeção de tráfego em um segmento de rede, aumentando assim sua segurança, haja vista a possível detecção de padrões relacionados com atividade maliciosa (assinaturas de malware). Devido à execução de Deep Packet Inspection, o desempenho desse tipo de solução tende a ser menor à medida que as taxas de transmissão ou a quantidade de assinaturas presentes na base aumentam. Uma possível abordagem para o aumento de desempenho dessas soluções é a implementação em espaço de kernel, mais especificamente, em espaço de driver, antes que as estruturas que representam um pacote sejam alocadas pelo sistema operacional. Desta forma, é possível escrever um programa BPF (Berkeley Packet Filter), anexado à primeira camada da pilha de rede do kernel Linux, o XDP (eXpress Data Path), que tem por objetivo realizar a detecção de assinaturas de malware. Este trabalho propõe o Sapo-boi (Sistema de Avaliação e Processamento de tráfegO baseado em BPF/XDP para Observação de Intrusões), a fim de mostrar a viabilidade da implementação de um sistema de detecção de intrusões por assinatura em espaço de kernel/driver, bem como discutir as implicações e limitações de fazê-lo. A solução é dividida em dois módulos, o Módulo de Suspeição: um programa BPF/XDP usado para o casamento inicial de padrões maliciosos em espaço de kernel, que redireciona pacotes considerados suspeitos para o espaço de usuário através de sockets XDP; e o Módulo de Avaliação: processo de usuário, para onde os pacotes oriundos do Módulo de Suspeição são redirecionados para avaliação aprofundada e veredito final. Os experimentos foram executados de forma a comparar o Sapo-boi com outras três soluções: duas delas totalmente em espaço de usuário, e uma que, como o Sapo-boi, também é dividida entre espaços de kernel e usuário. Os resultados apontam uma queda significativa da taxa de pacotes não avaliados pela solução proposta quando comparada às soluções em espaço de usuário, bem como indicam que a maneira como o Sapo-boi realiza a passagem de pacotes para o espaço de usuário é mais robusta do que a maneira realizada pela outra solução em kernel. Mais especificamente, num cenário com alto número de assinaturas a serem avaliadas (16 mil) e 10Gbps, o Sapo-boi deixa de avaliar pouco mais de 2% dos pacotes, ao passo Suricata e Snort deixam de avaliar 9,61% e 91,7%, respectivamente. Com relação à outra solução em espaço de kernel, com as mesmas métricas citadas anteriormente, o Sapo-boi é capaz de redirecionar 99,99% dos pacotes ao espaço de usuário, ao passo que a solução mencionada redireciona pouco mais de 91%, o que pode acarretar na ausência de alertas, que representam a real detecção da atividade maliciosa

Ироническая оценка советской действительности в творческой биографии Oлега Григорьева

This text is an attempt to acquaint the reader with the writer’s biography of Oleg Grigoryev, a Russian poet and a representative of “the literary underground”. His works can be classified as urban folklore. Most of his poems are full of harsh irony, which may shock with its dark humour. Grigoryev often resorts to the poetics of the absurd, which may lead a keen reader to the conclusion that he is close to the creative actions of the poetic group of the Oberiuty with Daniil Kharms and Alexander Vvedenski as their main representatives. In this light, Grigoryev’s poetry can be interpreted as a reflection of the dark Soviet reality in which he lived and with which he struggled. Such an attitude surely did not help him in succeeding within the official Russian literature

РЕЦЕПЦІЯ ТВОРЧОСТІ СЕРГІЯ ЄСЕНІНА І НІКОЛАЯ КЛЮЄВА В УКРАЇНІ (КИЇВСЬКЕ НАУКОВЕ КОЛО КЛЮЄВОСЛОВ)

Sergei Yesenin and Nikolai Klyuev are the poets whose works have been analyzed numerous times, especially in recent years. These analyses were deprived of analytical and interpretative narrowness, which resulted from censorship in the past. It should be emphasized that in Russia and other countries in the world the works by Yesenin were more often published than the works by Klyuev which disappeared because of ideological reasons for a few decades. Klyuev began to be mentioned after Stalin’s death and he was often accompanied by Yesenin. The older poet was presented in a bad light as a representative of kulak poetry and the one who hindered creative development of his follower. In this context critical literary works by Ukrainian researchers are presented in an interesting way because these people made an important contribution to the study of Russian “new peasant” poetry.Сергій Єсенін і Ніколай Клюєв – це поети, творчість яких дочекалася, особливо в останніх роках, численних опрацювань, позбавлених аналітичної та інтерпретаційної вузькості, що була у минулому наслідком надмірної запопадливості цензури. Належить підкреслити, що у видавничому обігу Росії та інших країн з’являлося радше прізвище Єсеніна, тоді як прізвище Клюєва, з чисто ідеологічного приводу, зникло з читацької рецепції на кілька десятиліть. Про нього почали говорити лише після смерті Сталіна, найчастіше, однак, коли займалися творчістю Єсеніна. Старший поет був представле- ний у негативному світлі, як представник кулацької поезії і як той, що утрудняє своєму учневі творчий розвиток. Інтерес у цьому контексті становлять літературно-критичні праці українських дослідників, які зробили великий внесок в науку про російську „новомужицьку” поезію.Сергій Єсенін і Ніколай Клюєв – це поети, творчість яких дочекалася, особливо в останніх роках, численних опрацювань, позбавлених аналітичної та інтерпретаційної вузькості, що була у минулому наслідком надмірної запопадливості цензури. Належить підкреслити, що у видавничому обігу Росії та інших країн з’являлося радше прізвище Єсеніна, тоді як прізвище Клюєва, з чисто ідеологічного приводу, зникло з читацької рецепції на кілька десятиліть. Про нього почали говорити лише після смерті Сталіна, найчастіше, однак, коли займалися творчістю Єсеніна. Старший поет був представлений у негативному світлі, як представник кулацької поезії і як той, що утрудняє своєму учневі творчий розвиток. Інтерес у цьому контексті становлять літературно-критичні праці українських дослідників, які зробили великий внесок в науку про російську „новомужицьку” поезію

A natureza é política : por uma crítica à Educação Ambiental na Base Nacional Comum Curricular

Orientadora: Camila Itikawa GimenesCoorientadora: Odisséa Boaventura de OliveiraTrabalho de Conclusão de Curso (Licenciatura) - Universidade Federal do Paraná. Setor de Ciências Biológicas. Curso de Graduação em Ciências Biológicas