Ironia w dramatach sowizdrzalskich przełomu XVI i XVII wieku

Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00

Effect of sex and menstrual cycle in women on starting speed, anaerobic endurance and muscle power

The aim of our study was to compare the indicators of starting speed, anaerobic endurance and power in women as well as men, and to investigate whether the values of these indicators differ in women during the follicular and luteal phases of the menstrual cycle. The studied group included 16 men and 16 women. The subjects performed the 20-second maximal cycling sprint test. The men performed the test twice at 14-day intervals. The women undertook the test 4 times: twice during the middle of follicular phase and twice in the middle of luteal phase in separate menstrual cycles. Hormonal changes during the menstrual cycle do not influence anaerobic performance, starting speed or anaerobic endurance in women. Anaerobic performance in men is higher than in women with similar aerobic performance expressed as VO2max/LBM (lean body mass). A lower power decrease with time was noted for women than men, with a similar time of maintaining power in both groups. This is evidence of women’s better anaerobic endurance compared to men. At the same time, the men had significantly better starting speed rates than women

Synthesis, Biological Activity, and NMR-Based Structural Studies of Deltorphin I Analogs Modified in Message Domain with a New a,a-Disubstituted Glycines

This article describes new deltorphin I analogs in which phenylalanine residues were replaced by the corresponding (R) or (S)-a-benzyl-b-azidoalanine, a-benzyl-b- (1-pyrrolidinyl)alanine, a-benzyl-b-(1-piperidinyl)alanine, and a-benzyl-b-(4-morpholinyl)-alanine residues. The potency and selectivity of the new analogs were evaluated by a competitive receptor binding assay in the rat brain using [3H]DAMGO (a l ligand) and [3H]DELT (a d ligand). The affinity of analogs containing (R) or (S)-abenzyl- b-azidoalanine in position 3 to d-receptors strongly depended on the chirality of the a,a-disubstituted residue. The conformational behavior of peptides modified with (R) or (S)-a-benzyl-b-(1-piperidinyl)Ala, which displays the opposite selectivity, was analyzed by 1H and 13C NMR. The l-selective Tyr-D-Ala-(R)- a-benzyl-b-(1-piperidinyl)Ala-Asp-Val-Val-Gly-NH2 lacks the helical conformation observed in the d-selective Tyr- D-Ala-(S)-a-benzyl-b-(1-piperidinyl)Ala-Asp-Val-Val-Gly- NH2. Our results support the proposal that differences between d- and l-selective opioid peptides are attributable to the presence or absence of a spatial overlap between the N-terminal message domain and the C-terminal address domain

Kwercetyna hamuje proliferację i zwiększa wrażliwość komórek raka jajnika na cisplatynę i paklitaksel

Introduction: Due to frequent diagnosis of ovarian cancer at an advanced clinical stage, in most cases surgical debulking is followed by chemotherapy. The principal cause of therapeutic failure involves incomplete surgery and resistance of neoplastic cells to chemotherapy. A search continues for substances which would overcome resistance to treatment and, as a result, would increase efficacy of the applied treatment. Quercetin represents one of more interesting compounds, which at present in subjected to several tests. Material and methods: Studies were performed on in vitro sensitivity of human ovarian cancer cell lines, SKOV-3, EFO27, OVCAR-3 and A2780P to low doses of quercetin and on the effect exerted by quercetin on sensitivity of the cell lines to cisplatin and pactitaxel. Results: The experiments proved that the studied cells of ovarian cancer manifest a similar sensitivity to quercetin. Following incubation of the cells with two distinct concentrations of quercetin and the studied cytostatic agents all the cells lines were found to significantly increase their sensitivity to pactitaxel In cases of two cell lines, OVCAR-2 and A2780P, they also significantly increased their sensitivity to cisplatin. Discussion: Our results demonstrated suitability of low quercetin doses (achievable using oral administration) as a substance which increases sensitivity of ovarian cancer cells to cisplatin and paclitaxel. The value of quercetin include its wide accessibility, efficacy and a broad range of activity but also its low toxicity, as compared to other examined compounds. Conclusions: Used in low doses, quercetin increases chemosensitivity of ovarian cancer cells.Wstęp: Ze względu na częste rozpoznawanie raków jajnika w zaawansowanym stadium klinicznym w większości przypadków po przeprowadzeniu zabiegu operacyjnego stosowana jest chemioterapia. Podstawową przyczyną niepowodzeń stosowanej terapii jest nieradykalność leczenia operacyjnego oraz oporność komórek nowotworowych na chemioterapię. Poszukuje się substancji, które pozwolą zwalczyć oporność na leczenie i w efekcie zwiększyć skuteczność stosowanej terapii. Jednym z ciekawszych związków poddawanych obecnie szeregowi badań jest kwercetyna. Materiał i metody: Przeprowadzono badania in vitro wrażliwości linii komórkowych ludzkiego raka jajnika SKOV-3, EFO27, OVCAR-3 i A2780P na niskie dawki kwercetyny oraz ocenę wpływu kwercetyny na wrażliwość linii komórkowych na cisplatynę i paklitaksel. Wyniki: Przeprowadzone doświadczenia wykazały, że badane komórki raka jajnika wykazują zbliżoną wrażliwość na kwercetynę. W wyniku inkubacji badanych komórek z dwoma różnymi stężeniami kwercetyny i z badanymi cytostatykami wykazaliśmy, że wszystkie linie istotnie zwiększyły swoją wrażliwość na paklitaksel. W przypadku dwóch linii – OVCAR-2 i A2780P uzyskaliśmy również istotny wzrost wrażliwości na cisplatynę. Dyskusja: Nasze badania wykazały przydatność niskich dawek kwercetyny (osiągalnych przy podaży doustnej), jako substancji zwiększającej wrażliwość komórek raka jajnika na cisplatynę i paklitaksel. Jej walory podkreśla nie tylko łatwa dostępność, skuteczność i szeroki zakres działania, ale również mała, w porównaniu z innymi badanymi substancjami, toksyczność. Wnioski: Kwercetyna zastosowana w niskich dawkach powoduje wzrost chemiowrażliwości komórek raka jajnika

Proton radiotherapy should be further developed in Poland

  Proton radiation therapy needs to be further developed in Poland by virtue of both epidemiological considerations and because this type of radiation exhibits very advantageous biological and physical properties. The underlying benefit of such therapy is to make lower integral radiation dose delivered to structures beyond a given target area, including critical organs, resulting in reduced toxicities for patients. Of somewhat less import is the improvement in dose distributions for target areas (vs photons), which can potentially bring about a better local control. As a result, proton radiotherapy is mainly indicated for paediatric cases, where any development of complications is most likely because of the long lifetimes and the heightened radiosensitivity of healthy tissues. The most recent studies also show that certain subpopulations of patients can benefit from proton beam radiotherapy in cases of widespread cancers such as from the lung or breast. A further advantage is found after conducting a cost-effectiveness analysis whereby proton beam radiotherapy was demonstrated as a cost-effective procedure, with both lowered costs for treating complications and indirect costs. By the term ‘development’ as used herein, it is understood that there is a need to open another proton therapy centre in Poland; this question however being left open in the presented article. Nevertheless, before taking such a high-level decision, the following requires consideration: the working experience garnered by the existing Cyclotron Centre at Bronowice (CCB), outcomes from current prospective clinical trials and, above all, delivering appropriately managed and coordinated oncological care for cancer patients in Poland regarding multi-centre collaboration between specialists

Methodological considerations for documenting the energy demand of dance activity: a review.

Previous research has explored the intensity of dance class, rehearsal, and performance and attempted to document the body's physiological adaptation to these activities. Dance activity is frequently described as: complex, diverse, non-steady state, intermittent, of moderate to high intensity, and with notable differences between training and performance intensities and durations. Many limitations are noted in the methodologies of previous studies creating barriers to consensual conclusion. The present study therefore aims to examine the previous body of literature and in doing so, seeks to highlight important methodological considerations for future research in this area to strengthen our knowledge base. Four recommendations are made for future research. Firstly, research should continue to be dance genre specific, with detailed accounts of technical and stylistic elements of the movement vocabulary examined given wherever possible. Secondly, a greater breadth of performance repertoire, within and between genres, needs to be closely examined. Thirdly, a greater focus on threshold measurements is recommended due to the documented complex interplay between aerobic and anaerobic energy systems. Lastly, it is important for research to begin to combine temporal data relating to work and rest periods with real-time measurement of metabolic data in work and rest, in order to be able to quantify demand more accurately

Quality of life of hemodialyzed patients with the consideration of the type of vascular access

  Introduction: Kidney disease is a major challenge for modern medicine, despite advances in its diagnosis and therapy. Hemodialysis, as one of the key renal replacement therapies, sustains patients' vital functions, but is associated with significant challenges in terms of the quality of life. Aim: To assess the quality of life of patients undergoing hemodialysis with consideration of the type of vascular access. Material and method: The study was conducted from November 2023 to March 2024 among patients of dialysis stations in the district of Jastrzębie, diversified in terms of age, place of residence, education, and marital status. The study used a diagnostic survey method with a self-constructed questionnaire and a KDQOL-SFTM tool. Results and conclusions: Patients with a fistula tend to have a higher quality of life, better physical and social functioning, and better overall health than patients using a vascular catheter. Gender and place of residence have no significant effect on the quality of life of hemodialyzed patients, regardless of the type of vascular access. Patients under 60 years of age show better physical health than older patients. Secondary and higher education correlates with higher quality of life in terms of symptoms. Marital status has a significant impact on physical health. Shorter duration of dialysis treatment is associated with better quality of life in terms of symptoms, disease quality of life and mental health. The absence of dialysis complications correlates with higher quality of life in terms of symptoms, quality of life in disease and physical health. The results of the study highlight the importance of the type of vascular access and socio-demographic factors in assessing the quality of life of hemodialyzed patients.  &nbsp