THEATRE AS THE REPRESENTATIVE SCENE OF THE POWER OF COURT: THE FIFTEENTH- AND SIXTEENTH-CENTURY ITALIAN EXEMPLA

Tra XV e XVI secolo il teatro diviene luogo deputato alla rappresentazione della corte . Il luogo teatrale manifesta emblematicamente la metafora del potere e del prestigio del casato . Sin dalla seconda metà del XV secolo la corte di Ferrara mette in atto, attraverso la figura di Pellegrino Prisciani, un’ operazione culturale orientata al recupero dei testi e del teatro classico.Il saggio analizza il coerente percorso della festa e della sua rappresentazione a Ferrara nel XV secolo e nel XVI secolo , evidenziando rapporti tematici e compositivi con gli affreschi di palazzo Schifanoia

Caravaggio in musica

Il contributo illustra dettagliatamente i dipinti di Caravaggio dedicati ai soggetti di carattere musicale. Le iconografie ideate da Caravaggio riflettono il contesto culturale e le novità emerse nell'ambito della fiorentina Camerata dei Bardi; lo stretto rapporto che lega il teorico Emilio de' Cavalieri con il cardinal Francesco Maria Bourbon del Monte, committente del pittore. I dipinti illustrano precise partiture musicali legate al revival della musica antica e ai temi del "Recitar cantando"

Caravaggio e la luce

L'articolo ripercorre il valore della luce nella pittura di Caravaggio attraverso il commento e il giudizio critico di tutte le fonti secentesche, principalmente Baglione, Bellori, e fino al Settecento

The energy efficient engine project

The Energy Efficient Engine Project is directed at providing, by 1984, the advanced technologies which could be used for a generation of fuel conservative turbofan engines. The project is conducted through contracts with the General Electric Company and Pratt and Whitney Aircraft. The scope of the entire project and the current status of these efforts are summarized. A description of the preliminary designs of the fully developed engines is included and the potential benefits of these advanced engines, as well as highlights of some of the component technology efforts conducted to date, are discussed

Design approaches to more energy efficient engines

The status of NASA's Energy Efficient Engine Project, a comparative government-industry effort aimed at advancing the technology base for the next generation of large turbofan engines for civil aircraft transports is summarized. Results of recently completed studies are reviewed. These studies involved selection of engine cycles and configurations that offer potential for at least 12% lower fuel consumption than current engines and also are economically attractive and environmentally acceptable. Emphasis is on the advancements required in component technologies and systems design concepts to permit future development of these more energy efficient engines

Small, low cost, expendable turbojet engine. 2: Performance characteristics

A small experimental axial-flow turbojet engine was tested at sea level static conditions and over a range of simulated flight conditions to evaluate its performance as well as to demonstrate the feasibility of low-cost concepts utilized in its design. Testing was conducted at engine speeds as high as 37,000 rpm and at turbine inlet temperatures as high as 1,272 K. For maximum speed the engine produced a net thrust of 3,118 newtons at sea level static operation and 2,318 newtons at its cruise condition of M0 = 0.8 and 6,096 meters. Data obtained over a range of inlet Reynolds number indexes for nominal M0 of 0.38 revealed similar effects or trends on compressor characteristics of those previously established for much larger engines

HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers

Valproic acid (VPA), a histone deacetylase inhibitor, causes differentiation in different cell lines and in a cell-specific manner; yet, its effect on megakaryocytic (MK) differentiation has not been studied. We evaluated whether VPA induces MK differentiation in a UT-7 cell line through histone acetylation in the GpIIIa gene region and activation of the ERK pathway. UT-7 cells, derived from megakaryoblastic leukemia, were treated with VPA at various concentrations, and the expression of differentiation markers as well as the gene expression profile was assessed. Flow cytometry, immunoblot analysis, and RT-PCR demonstrated that VPA induced the expression of the early MK markers GpIIIa (CD61) and GpIIb/IIIa (CD41) in a dose-dependent manner. The VPA-treated cells showed hyperacetylation of the histones H3 and H4; in particular, histone acetylation was found to have been associated with CD61 expression, in that the GpIIIa promoter showed H4 hyperacetylation, as demonstrated by the chromatin immunoprecipitation assay. Furthermore, activation of the ERK pathway was involved in VPA-mediated CD61/CD41 expression and in cell adhesion, as demonstrated by using the MEK/ERK inhibitor U0126. In conclusion, the capacity of VPA to commit UT-7 cells to MK differentiation is mediated by its inhibitory action on HDAC and the long-lived activation of ERK1/2

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population

The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investigate the role of the MEK/ERK pathway in controlling the cancer stem-like phenotype using a model of rhabdospheres derived from the embryonal rhabdomyosarcoma cell line (RD)

Performance analysis of the toroidal field ITER production conductors

The production of the superconducting cables for the toroidal field (TF) magnets of the ITER machine has recently been completed at the manufacturing companies selected during the previous qualification phase. The quality assurance/quality control programs that have been implemented to ensure production uniformity across numerous suppliers include performance tests of several conductor samples from selected unit lengths. The short full-size samples (4 m long) were subjected to DC and AC tests in the SULTAN facility at CRPP in Villigen, Switzerland. In a previous work the results of the tests of the conductor performance qualification samples were reported. This work reports the analyses of the results of the tests of the production conductor samples. The results reported here concern the values of current sharing temperature, critical current, effective strain and n-value from the DC tests and the energy dissipated per cycle from the AC loss tests. A detailed comparison is also presented between the performance of the conductors and that of their constituting strands

L’objection de conscience dans la post-modernité

SOMMARIO: 1. Avant propos – 2. Le concept de l’objection de conscience – 3. L’objection de conscience dans la modernité – 4. L’objection comme témoignage