Fear of failure among a sample of Jordanian undergraduate students

Ziad M Alkhazaleh, Ahmad M Mahasneh Department of Educational Psychology, Faculty of Education Sciences, The Hashemite University, Zarqa, Jordan Background: Fear of failure (FoF) is the motivation to avoid failure in achievement tests, and involves cognitive, behavioral, and emotional experiences. Aims: The primary purpose of this study was to determine the level of FoF among students at The Hashemite University, Jordan. We were also interested in identifying the difference in the level of FoF between the sexes, the academic level, and grade-point average (GPA). Method: A total of 548 students participated in the study by completing the Performance Failure Appraisal Inventory. Descriptive statistics (mean and SD), independent sample t-test, and one-way analysis of variance were used to analyze the data collected. Results: The results indicated the overall mean FoF to be –0.34. There were also significant differences between male and female students' level of fear in experiencing shame and embarrassment. Significant differences were found between the four academic level groups in the following fear categories: experiencing shame and embarrassment, important others losing interest, and fear of upsetting important others. The results also showed significant differences between the GPA level groups in the following fear categories: experiencing shame and embarrassment, diminishing of one's self-esteem, having an uncertain future, fear of important others losing interest, and fear of upsetting important others. Conclusion: FoF may be an important consideration when trying to understand student behavior in the university. Moreover, the level of FoF differs between sexes, academic levels, and GPA levels. Keywords: fear, fear of failure, Jordanian student

The relationship between spiritual intelligence and personality traits among Jordanian university students

Ahmad M Mahasneh,1 Nizar A Shammout,1 Ziad M Alkhazaleh,1 Ahmed F Al-Alwan,1 Jawhara D Abu-Eita2 1Department of Educational Psychology, Faculty of Education Sciences, Hashemite University, Zarqa, Jordan; 2Department of Curricula, Princess Alia College, Al-Balaq’a Applied University, Amman, Jordan Abstract: This study was aimed at identifying the level of spiritual intelligence and its correlation with personality traits among a group of Jordanian undergraduate students. A purposive sample of 716 male and female students was chosen from different faculties at the Hashemite University. Two questionnaires on spiritual intelligence and personality traits were distributed to members of the sample during the academic year 2013–2014. Results illustrated a medium level of spiritual intelligence in students, and indicated a positive and statistically significant relationship between spiritual intelligence dimensions (critical existential thinking, personal meaning production, transcendental awareness, and conscious state expansion) and personality traits (neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), but no significant correlation between personal meaning production and transcendental awareness dimensions and neuroticism personality traits. Finally, regression analysis results indicate that critical existential thinking is the first predictor dimension of spiritual intelligence in terms of neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness. In the light of the results of this study, many recommendations were written by the researchers. Keywords: Spiritual intelligence, personality traits, Jordanian University student

Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

Qosay A Al-Balas,1 Mohammad A Hassan,1 Nizar A Al-Shar’i,1 Nizar M Mhaidat,2 Ammar M Almaaytah,3 Fatima M Al-Mahasneh,1 Israa H Isawi1 1Department of Medicinal Chemistry and Pharmacognosy, 2Department of Clinical Pharmacy, 3Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan Background: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes. Tumor cells have high glycolytic activity, leading to increased cellular levels of these toxic metabolites. The increased activity of the detoxification system in cancerous cells makes this pathway a viable target for developing novel anticancer agents. In this study, we examined the potential utility of non-glutathione-based inhibitors of the Glo-I enzyme as novel anticancer drugs.Methods: Computer-aided drug design techniques, such as customized pharmacophoric features, virtual screening, and flexible docking, were used to achieve the project goals. Retrieved hits were extensively filtered and subsequently docked into the active site of the enzyme. The biological activities of retrieved hits were assessed using an in vitro assay against Glo-I.Results: Since Glo-I is a zinc metalloenzyme, a customized Zn-binding pharmacophoric feature was used to search for selective inhibitors via virtual screening of a small-molecule database. Seven hits were selected, purchased, and biologically evaluated. Three of the seven hits inhibited Glo-I activity, the most effective of which exerted 76.4% inhibition at a concentration of 25 µM.Conclusion: We successfully identified a potential Glo-I inhibitor that can serve as a lead compound for further optimization. Moreover, our in silico and experimental results were highly correlated. Hence, the docking protocol adopted in this study may be efficiently employed in future optimization steps. Keywords: cancer, glyoxalase-I, zinc-binding feature, flexible docking, Discovery Studio 3.5, keto