260 research outputs found

    Insigne France, insignifiance

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    Formé, jeune, à «l'idée du bien», Vadeboncoeur se veut un admirateur inconditionnel de la France. En Amérique, il « se sent inférieur », réellement « exilé » du pays qu'il voit « du signe féminin », qu'il désire « protéger » et « adorer », dédaignant cependant les Français qui lui « sont quelque peu étrangers ». Il dessine ainsi une France d'écrivains, de grands hommes, de foi, indépendamment de l'histoire et surtout de la vie des « manants » dont il dit descendre. Ce dualiste impénitent tient « mythiquement » à une France de « perfection » qu'il lui est bien facile d'opposer aux ignobles Anglo-Saxons. « Lucidité » ? « Préjugé » ? Poésie ? Utopie ?Tuming early in life toward "the idea of the good", Vadeboncur saw himself as an unreserved admirer of France. As a North American, he "believed himself inferior", an "exile" from a"feminine" land which he longed to "protect" and adore" ail the while professing disdain for the French, whom he viewed as "somehow alien" to himself. Vadeboncoeur's France is a country of writers and great men, and of faith, existing independently of history and above all of the life of the "churls" to whom he traced his own ancestry. An uncompromising dualist, he clung "mythically" to the notion of a France of "perfection,"which he found only too easy to place in opposition to, Anglo-Saxon ignobleness. Was it lucidity" or "prejudice'? Poetry or utopia

    Small molecule-based photocrosslinkable fluorescent materials toward multilayered and high-resolution emissive patterning

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    International audiencea Solution-processable green and red-emitting fluorophores possessing photopolymerizable acrylate units have been synthesized. Photocrosslinking was successfully performed in neat thin films at room temperature under low-dose UV irradiation at 365 nm. No further curing step was necessary to achieve insoluble emissive thin films displaying high optical quality. Up to 80% of the green emitting material processed as a non-doped thin film remained after photopolymerization. Despite competitive energy transfer occurring between the excited photoinitiator and the radiative excited state of red-emitting materials, up to 40% of the initial thickness could be achieved after development. The very low RMS roughness of the green and red photocrosslinked thin films after development (RMS o 0.7 nm) allowed us to fabricate multicolored stacks again with high optical quality (RMS roughness o 1.3 nm) after two cycles of irradiation and development involving successively red and green emitters. Resolved patterns as small as 600 nm in width could be obtained upon photolithography performed under an air atmosphere. High adhesion of the photocrosslinked materials on surfaces makes the resulting emissive thin films very promising for realizing complex emissive structures on flat or bend substrates as required in multiple applications such as optical data storage, organic lasers, organic light emitting diodes or counterfeiting

    Geography and the Paris Academy of Sciences: politics and patronage in early 18th-century France

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    This essay considers the politics and patronage of geography in early-modern France. It examines how the Paris Academy of Sciences, widely acknowledged as the 18th century’s pre-eminent scientific society, came to recognise geography as an independent science in 1730, a century before the establishment of the first geographical societies. Although the Academy was centrally concerned with cartography from its inception in 1666, it initially afforded no official status to geography, which was viewed either as a specialised form of historical inquiry or as a minor component within the hegemonic science of astronomy. The rise of Newtonian mathematics and the associated controversy about the shape of the earth challenged the Academy’s epistemological foundations and prompted a debate about the educational and political significance of geography as a scientific practice. The death in 1726 of Guillaume Delisle, a prominent Academy astronomer-cartographer and a popular geography tutor to the young Louis XV, led to a spirited campaign to elect Philippe Buache, Delisle’s prot�eg�e, to a new Academy position as a geographer rather than an astronomer. The campaign emphasised the social and political utility of geography, though the Academy’s decision to recognise this new and distinctively modern science was ultimately facilitated by traditional networks of patronage within the French Royal Court

    Les armes

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    Copia digital : Junta de Castilla y León. Conserjería de Cultura y Turismo, 201

    L'art indien

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    Copia digital : Junta de Castilla y León. Conserjería de Cultura y Turismo, 201

    Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies.

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    peer reviewedN-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling procedure of [18F]SFB starting from a tin precursor. This method circumvents volatile radioactive side-products and simplifies automatization. [18F]SFB was obtained after HPLC purification in a yield of 42 + 4% and a radiochemical purity (RCP) > 99% (n = 6). In addition, we investigate the automation of the coupling of [18F]SFB to a nanobody (cAbBcII10, targeting β-lactamase enzyme) and purification by size exclusion chromatography (PD-10 desalting column) to remove unconjugated reagent. Production and use of [18F]SFB were implemented on a radiosynthesis unit (Neptis®). The fully automated radiosynthesis process including purification and formulation required 160 min of synthesis time. [18F]SFB-labeled nanobody was obtained in a yield of 21 + 2% (activity yield 12 + 1% non-decay corrected) and a radiochemical purity (RCP) of > 95% (n = 3). This approach simplifies [18F]SFB synthesis to one-step, enhances the yield in comparison to the previous report and enables the production of radiolabeled nanobody on the same synthesis module

    À propos des Anthies du sous-genre Pachymorpha Hope [Col. Carabidae]

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    Maindron Maurice. À propos des Anthies du sous-genre Pachymorpha Hope [Col. Carabidae]. In: Bulletin de la Société entomologique de France, volume 10 (9),1905. p. 134

    À propos des Anthies du sous-genre Pachymorpha Hope [Col. Carabidae]

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    Sur le genre Phloeotherates Bates [Col.]

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    Maindron Maurice. Sur le genre Phloeotherates Bates [Col.]. In: Bulletin de la Société entomologique de France, volume 11 (18),1906. p. 251
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