199 research outputs found

    Multiscaling analysis of high resolution space-time lidar-rainfall

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    In this study, we report results from scaling analysis of 2.5 m spatial and 1 s temporal resolution lidar-rainfall data. The high resolution spatial and temporal data from the same observing system allows us to investigate the variability of rainfall at very small scales ranging from few meters to ~1 km in space and few seconds to ~30 min in time. The results suggest multiscaling behaviour in the lidar-rainfall with the scaling regime extending down to the resolution of the data. The results also indicate the existence of a space-time transformation of the form <i>t</i>~<i>L<sup>z</sup></i> at very small scales, where <i>t</i> is the time lag, <i>L</i> is the spatial averaging scale and <i>z</i> is the dynamic scaling exponent

    A simple and effective method for quantifying spatial anisotropy of time series of precipitation fields

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    The spatial shape of a precipitation event has an important role in determining the catchment's hydrological response to a storm. To be able to generate stochastic design storms with a realistic spatial structure, the anisotropy of the storm has to be quantified. In this paper, a method is proposed to estimate the anisotropy of precipitation fields, using the concept of linear Generalized Scale Invariance (GSI). The proposed method is based on identifying the values of GSI parameters that best describe isolines of constant power on the two-dimensional power spectrum of the fields. The method is evaluated using two sets of simulated fields with known anisotropy and a measured precipitation event with an unknown anisotropy from Brisbane, Australia. It is capable of accurately estimating the anisotropy parameters of simulated nonzero fields, whereas introducing the rain-no rain intermittency alters the power spectra of the fields and slightly reduces the accuracy of the parameter estimates. The parameters estimated for the measured event correspond well with the visual observations on the spatial structure of the fields. The method requires minimum amount of decision making and user interaction, making it suitable for analyzing anisotropy of storm events consisting of long time series of fields with a changing spatial structure.Peer reviewe

    Impacts Of Transit Oriented Developments (TOD) And Mixed Use Centers (MUC) In Dallas-fort Worth Metroplex On Housing Values And Demographic Composition

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    Suburban sprawl was attributed to be the cause of number of problems such as traffic congestion, depletion of natural resources, and decreasing air quality. Over the past two decades, policy makers and smart growth proponents encouraged Transit-Oriented Developments (TOD) and Mixed Use Centers (MUC) to increase transit ridership and development density; revitalize inner-city neighborhoods; improve environmental quality and livability; and to counteract suburban sprawl and real estate market forces in various communities in the U.S. Though many policy makers, urban planners, environmentalists see significant opportunities in sustainable development, there have been concerns related to affordability of housing combined with transportation, possibly resulting in social inequality in terms of income, race, and ethnicity in sustainable developments in DFW Region. This research study primarily focuses on analyzing the change housing values of MUCs and TODs in the four core counties (Dallas, Tarrant, Collin, and Denton) of the Dallas Fort Worth (DFW) region and its effects on income, race, ethnicity of persons living in housing in MUCs and TODs in the DFW region between 2000 and 2009. The results of the study identified several significant independent or explanatory variables that affect the changes in housing values, median income, and minority percentages in the four-county study area. The groups of variables affecting the above factors include Demographic Variables, Location Variables, Transportation Access Variables, Development Variable, and Housing Supply Variables. These groups include specific variables such as percentage of persons working in professional occupations, distance to parks, number of major employers per square mile, type of development, etc. All these variables were statistically significant in explaining the variation in housing values, changes in income, and changes in minority percentage. Conclusions and policy recommendations were derived from the research study providing a stepping stone for further analysis in this research area

    4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein C

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    Mutations in the SFTPC gene, encoding surfactant protein–C (SP-C), are associated with interstitial lung disease (ILD). Knowledge of the intracellular fate of mutant SP-C is essential in the design of therapies to correct trafficking/processing of the proprotein, and to prevent the formation of cytotoxic aggregates. We assessed the potential of a chemical chaperone to correct the trafficking and processing of three disease-associated mutant SP-C proteins. HEK293 cells were stably transfected with wild-type (SP-C(WT)) or mutant (SP-C(L188Q), SP-C(Δexon4), or SP-C(I73T)) SP-C, and cell lines with a similar expression of SP-C mRNA were identified. The effects of the chemical chaperone 4-phenylbutyric acid (PBA) and lysosomotropic drugs on intracellular trafficking to the endolysosomal pathway and the subsequent conversion of SP-C proprotein to mature peptide were assessed. Despite comparable SP-C mRNA expression, proprotein concentrations varied greatly: SP-C(I73T) was more abundant than SP-C(WT) and was localized to the cell surface, whereas SP-C(Δexon4) was barely detectable. In contrast, SP-C(L188Q) and SP-C(WT) proprotein concentrations were comparable, and a small amount of SP-C(L188Q) was localized to the endolysosomal pathway. PBA treatment restored the trafficking and processing of SP-C(L188Q) to SP-C(WT) concentrations, but did not correct the mistrafficking of SP-C(I73T) or rescue SP-C(Δexon4). PBA treatment also promoted the aggregation of SP-C proproteins, including SP-C(L188Q). This study provides proof of the principle that a chemical chaperone can correct the mistrafficking and processing of a disease-associated mutant SP-C proprotein

    Dosimetric characterization of a microDiamond detector in clinical scanned carbon ion beams

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    Purpose: To investigate for the first time the dosimetric properties of a new commercial synthetic diamond detector (PTW microDiamond) in high-energy scanned clinical carbon ion beams generated by a synchrotron at the CNAO facility. Methods: The detector response was evaluated in a water phantom with actively scanned carbon ion beams ranging from 115 to 380 MeV/u (30-250 mm Bragg peak depth in water). Homogeneous square fields of 3×3 and 6×6 cm2 were used. Short- and medium-term (2 months) detector response stability, dependence on beam energy as well as ion type (carbon ions and protons), linearity with dose, and directional and dose-rate dependence were investigated. The depth dose curve of a 280 MeV/u carbon ion beam, scanned over a 3×3 cm<sup>2</sup> area, was measured with the microDiamond detector and compared to that measured using a PTW Advanced Markus ionization chamber, and also simulated using FLUKA Monte Carlo code. The detector response in two spread-out-Bragg-peaks (SOBPs), respectively, centered at 9 and 21 cm depths in water and calculated using the treatment planning system (TPS) used at CNAO, was measured. Results: A negligible drift of detector sensitivity within the experimental session was seen, indicating that no detector preirradiation was needed. Short-term response reproducibility around 1% (1 standard deviation) was found. Only 2% maximum variation of microDiamond sensitivity was observed among all the evaluated proton and carbon ion beam energies. The detector response showed a good linear behavior. Detector sensitivity was found to be dose-rate independent, with a variation below 1.3% in the evaluated dose-rate range. A very good agreement between measured and simulated Bragg curves with both microDiamond and Advanced Markus chamber was found, showing a negligible LET dependence of the tested detector. A depth dose curve was also measured by positioning the microDiamond with its main axis oriented orthogonally to the beam direction. A strong distortion in Bragg peak measurement was observed, confirming manufacturer recommendation on avoiding such configuration. Very good results were obtained for SOBP measurements, with a difference below 1% between measured and TPS-calculated doses. The stability of detector sensitivity in the observation period was within the experimental uncertainty. Conclusions: Dosimetric characterization of a PTW microDiamond detector in high-energy scanned carbon ion beams was performed. The results of the present study showed that this detector is suitable for dosimetry of clinical carbon ion beams, with a negligible LET and dose-rate dependence

    Prevention of Sensitive Information by Enhancing Cloud Access Control

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    the scheme prevents replay attacks and supports creation, modification, and reading data stored in the cloud. We also address user revocation. Moreover, our authentication, and storage overheads are comparable to centralized approaches. To better protect data security, this paper makes the first attempt to formally address and which are centralized. The communication, computation access control scheme is decentralized and robust; unlike other access control schemes designed for clouds the problem of authorized data. Different from traditional existing systems, the differential privileges of users are further considered in duplicate check besides the data itself by encrypting the file with differential privilege keys. Unauthorized users cannot decrypt the cipher text even collude with the S-CSP. Security analysis of the definitions specified in the demonstrates that our system is secure in terms proposed security model

    Statistical Downscaling of Rainfall using Large-Scale Predictors: Dynamic Model Outputs vs. Reanalysis Data

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    A warmer climate is expected to lead to more serious natural disasters, such as heavy storms, prolonged droughts and frequent floods. For a high-density urban region, the flash flood problem may become worse due to possible increasing frequency and magnitude of short-duration rainfalls in the future. A Global Circulation Model (GCM) is a powerful tool to assess the climate change impact. However, the resolution of a GCM output is generally too coarse to be applicable to small regions directly. Two types of approaches, dynamical and statistical downscaling, could be used for bridging the gap between GCM and local climate information. Compared with dynamical downscaling, the statistical approach is more flexible and computationally less intensive. In addition, statistical downscaling tools may be sensitive to the resolution of large-scale predictors. In this study, two downscaling approaches are compared. The first is to use a statistical method (Automatic Statistical Downscaling, ASD) directly to downscale large-scale predictors (i.e. ERA-Interim Reanalysis data) to local rainfall. The second is to combine a dynamical (i.e. MM5) and a statistical method (ASD) to generate the station-level data. The study site is the City of Edmonton and the resolutions of large-scale GCM predictors and dynamical model output are about 150 km and 27 km, respectively. The results show that the downscaled results based on predictors from MM5 is better than that from ERA-Interim, in terms of both accuracy and uncertainty range.

    Evaluation of a synthetic single-crystal diamond detector for relative dosimetry on the Leksell Gamma Knife Perfexion radiosurgery system

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    Purpose: To evaluate the new commercial PTW-60019 synthetic single-crystal microDiamond detector (PTW, Freiburg, Germany) for relative dosimetry measurements on a clinical Leksell Gamma Knife Perfexion radiosurgery system. Methods: Detector output ratios (DORs) for 4 and 8 mm beams were measured using a micro- Diamond (PTW-60019), a stereotactic unshielded diode [IBA stereotactic field detector (SFD)], a shielded diode (IBA photon field detector), and GafChromic EBT3 films. Both parallel and transversal acquisition directions were considered for PTW-60019 measurements. Measured DORs were compared to the new output factor reference values for Gamma Knife Perfexion (0.814 and 0.900 for 4 and 8 mm, respectively). Profiles in the three directions were also measured for the 4 mm beam to evaluate full width at half maximum (FWHM) and penumbra and to compare them with the corresponding Leksell GammaPlan profiles. Results: FWHM and penumbra for PTW-60019 differed from the calculated values by less than 0.2 and 0.3 mm, for the parallel and transversal acquisitions, respectively. GafChromic films showed FWHM and penumbra within 0.1 mm. The output ratio obtained with the PTW-60019 for the 4 mm field was 1.6% greater in transverse direction compared to the nominal value. Comparable differences up to 0.8% and 1.0% for, respectively, GafChromic films and SFD were found. Conclusions: The microDiamond PTW-60019 is a suitable detector for commissioning and routine use of Gamma Knife with good agreement of both DORs and profiles in the three directions
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