Micrometeoroids and debris on LDEF

Two experiments within the French Cooperative Payload (FRECOPA) and devoted to the detection of cosmic dust were flown on the Long Duration Exposure Facility (LDEF). A variety of sensors and collecting devices have made possible the study of impact processes on dedicated sensors and on materials of technological interest. Examination of hypervelocity impact features on these experiments gives valuable information on the size distribution and nature of interplanetary dust particles in low-Earth orbit (LEO), within the 0.5-300 micrometer size range. However no crater smaller than 1.5 microns has been observed, thus suggesting a cut-off in the near Earth particle distribution. Chemical investigation of craters by EDX clearly shows evidence of elements (Na, Mg, Si, S, Ca, and Fe) consistent with cosmic origin. However, remnants of orbital debris have been found in a few craters; this can be the result of particles in eccentric orbits about the Earth and of the 8 deg offset in the orientation of LDEF. Crater size distribution is compared with results from other dust experiments flown on LDEF and with current models. Possible origin and orbital evolution of micrometeoroids is discussed. Use of thin foil detectors for the chemical study of particle remnants looks promising for future experiments

Study of cosmic dust particles on board LDEF: The FRECOPA experiments AO138-1 and AO138-2

Two experiments, within the French Cooperative Payload (FRECOPA) and devoted to the detection of cosmic dust, were flown on the LDEF. A variety of sensors and collecting devices have made possible the study of impact processes on materials of technological interest. Preliminary examination of hypervelocity impact features gives valuable data on size distribution and nature of interplanetary dust particles in low earth orbit, within the 0.5 to 300 micrometer size range. Most of the events detected on the trailing face of LDEF are expected to be the result of impacts of meteoritic particles only. So far, chemical analysis of craters by EDS clearly shows evidence of elements (Na, Mg, Si, S, Ca, and Fe) consistent with cosmic origin. Systematic occurrence of C and O in crater residues is an important result, to be compared with the existence of CHON particles detected in P-Halley comet nucleus. Crater size distribution is in good agreement with results from other dust experiments flown on LDEF. However, no crater smaller than 1.5 micron was observed, thus suggesting a cutoff in the near earth particle distribution. Possible origin and orbital evolution of micrometeoroids is discussed

Future career plans of Malawian medical students: a cross-sectional survey.

BACKGROUND: Malawi has one of the lowest physician densities in the world, at 1.1 doctors per 100,000 population. Undergraduate training of doctors at the national medical school has increased considerably in recent years with donor support. However, qualified doctors continue to leave the public sector in order to work or train abroad. We explored the postgraduate plans of current medical students, and the extent to which this is influenced by their background. METHODS: A self-administered questionnaire was developed after discussion with students and senior staff. This included questions on background characteristics, education before medical school, and future career plans. This was distributed to all medical and premedical students on campus over 1 week and collected by an independent researcher. One reminder visit was made to each class. Chi-squared tests were performed to investigate the relationship of student characteristics with future career plans. RESULTS: One hundred and forty-nine students completed the questionnaire out of a student body of 312, a response rate of 48%. When questioned on their plans for after graduation, 49.0% of students plan to stay in Malawi. However, 38.9% plan to leave Malawi immediately. Medical students who completed a 'premedical' foundation year at the medical school were significantly more likely to have immediate plans to stay in Malawi compared to those who completed A-levels, an advanced school-leaving qualification (P = 0.037). Current premedical students were slightly more likely to have immediate plans to work or train in Malawi compared to medical students (P = 0.049). However, a trend test across all the years was not significant. When asked about future plans, nearly half of students intend to work or train outside Malawi. CONCLUSIONS: The majority of respondents plan to leave Malawi in the future. The effectiveness of the substantial upscaling of medical education in Malawi may be diminished unless more medical students plan to work in Malawi after graduation

Global public health training in the UK: preparing for the future.

BACKGROUND: Many major public health issues today are not confined by national boundaries. However, the global public health workforce appears unprepared to confront the challenges posed by globalization. We therefore sought to investigate whether the current UK public health training programme adequately prepares its graduates to operate in a globalized world. METHODS: We used mixed methods involving an online cross-sectional survey of UK public health trainees on the international content of the Faculty of Public Health's written examination, a qualitative review of the Faculty's 2007 training curriculum and a questionnaire survey of all training deaneries in the UK. RESULTS: We found that global health issues are not addressed by the current training curriculum or in the written examination despite trainee interest for this. Many of the deaneries were also unreceptive to international placements. CONCLUSIONS: Despite the recognized educational legitimacy of global health placements and the favourable UK policy context, the opportunities and international content of public health training remain limited. In order to retain its position as a leader in the field of public health, the UK needs to adapt its training programme to better reflect today's challenges

Never been industrialized: a tale of African structural change

Africa is a case of structural change without industrialization and without diversification. Agriculture�s decline was matched by an increase in services and non-manufacturing industry, with manufacturing remaining low and stagnant throughout the post-colonial period. To what extent do these patterns of structural change account for the weak growth dynamics observed in the continent? We provide evidence that what is damaging for growth in Africa is not the expansion in services, but rather the reallocation of economic activity from agriculture to non-manufacturing industry. Because non-manufacturing industry is mainly mining, our results point to a form of resource curse.

Financial interests of patient organisations contributing to technology appraisal at England's National Institute for Health and Care Excellence (NICE): a policy review

Objectives: To investigate the prevalence of financial interests among patient organisations contributing to health technology assessment at the National Institute for Health and Care Excellence (NICE) in England, and the extent to which current disclosure policy ensures decision-making committees are aware of these interests. Design: Policy review using annual accounts, reports and websites of patient organisations, a database of payments declared by pharmaceutical manufacturers (Disclosure UK), other manufacturer declarations, responses from patient organisations, and declarations of interests by nominated representatives of patient organisations. Setting: Appraisals of medicines and treatments for use in the English and Welsh National Health Service. Participants: 53 patient organisations contributing to 41 NICE technology appraisals published in 2015 and 2016, with 117 separate occasions that a patient organisation contributed to the appraisal of a technology. Main outcome measures: (i) Prevalence of specific interests, i.e. funding from manufacturer(s) of a technology under appraisal or competitor products; (ii) Proportion of specific interests of which NICE decision-making committees were aware; (iii) Proportion of specific interests for which disclosure was not required by current NICE policy. Results: 38/53 (71.7%) patient organisations had accepted funding from the manufacturer(s) of a technology or a competitor product in the same or previous year that they had contributed to the appraisal of that technology. Specific interests were 46 present on 92 out of 117 (78.6%) occasions that patient organisations contributed to appraisals in 2015 and 2016. NICE decision-making committees were aware of less than a third of specific interests (36/115, 31.3%). For over half of the specific interests of which committees were unaware (42/79, 53.2%), disclosure by patient organisations was not required by current NICE policy. Conclusions: Specific interests are highly prevalent among patient organisations contributing to health technology assessment. NICE is reviewing its disclosure policy to ensure that decision-making committees are aware of all relevant interests

Further analysis of LDEF FRECOPA micrometeoroid remnants

In the Al collectors of experiment A0138-1 of the French Cooperative Payload (FRECOPA) payload, we identified a population of small craters (3-9 microns in diameter) induced by the impacts of micron-sized grains, mainly of extraterrestrial origin. Chemical analyses of the Interplanetary Dust Particle (IDP) remnants were made in the bottoms and on the rims of the craters, in addition to immediate off-rim areas. So far, the compositional investigation of the craters by Energy Dispersive Spectroscopy (EDS) has shown evidence of an extraterrestrial origin for the impacting grains. The systematic presence of C and O in the residues has been reported and may be compared with the existence of particles showing high proportions of biogenic light elements and detected in the close environment of P-Halley comet nucleus (called CHON particles). An analytical protocol has been established in order to extract molecular and possible isotopic information on these grains, a fraction of which could be of cometary origin. Although these very small craters may show crater features that are typical of the larger Long Duration Exposure Facility (LDEF) population (greater than 50 microns), some show unique morphologies that we have not previously observed. Our initial Laser Induced Mass Spectrometry (LIMS) analytical results show strong signals for nitrogen-bearing ions in craters characterized by high C and O contents; they also suggest that carbon contents in some craters could exceed that known for carbonaceous chondrites

Assessing the quality of health technology registers for national guidance development.

Background: The National Institute of Health and Care Excellence makes use of registers to collect data for technologies that require more evidence to inform future decision-making. This is particularly so for the Interventional Procedures Programme, which since 2003 has produced guidance for procedures that are typically not well established, meaning that named registers are often recommended for future data collection. Methods: We constructed a questionnaire based on quality standards for recommended registers defined by the Interventional Procedures Programme. All guidance from 2003 to 2016 were reviewed to identify recommended registers and compile a list of corresponding registries. We made a maximum of four attempts to contact each registry. Each register was scored on seven quality standards: accessibility, responsiveness, data publication, data coverage, data validity, independent oversight and data protection, with a maximum of 14 points. Results: We obtained responses from 17 out of 24 eligible registries, a response rate of 70.8%. The mean total score was 8.5 (standard deviation 2.9, range 4-14). Overall, the quality of recommended registers was disappointing, with a split between large registries that scored highly across all standards and smaller registries that scored poorly. Conclusions: This the first study to our knowledge to assess the quality of registers recommended by health technology assessment agencies. Only a limited number of registers were mature enough to deliver evidence of sufficiently high quality to inform funding decisions. A standardised quality assessment tool is needed to evaluate registers before their recommendation for observational data gathering by decision-making bodies