CoQ10 and vitamin A supplementation support voice rehabilitation. A double-blind, randomized, controlled, three-period cross-over pilot study

Objectives: To evaluate the effectiveness of an adjuvant therapy (CoQ10 in its watersoluble form and vitamin A) in supporting voice rehabilitation in a large group of patients with muscle tension dysphonia (MTD). Study Design: Twelve-week, double-blind, randomized, controlled, three-period crossover pilot study. The primary endpoint was the change in the Dysphonia Severity Index (DSI) over the 12-week study period. Secondary endpoints were the changes in the subcomponents of DSI, including MPT, F0-high, I-low, and jitter. Exploratory endpoints were the changes in the Shimmer and in Voice Handicap Index (VHI). Methods: Patients were randomly assigned in a 1:1 ratio to two counter-balanced arms. Group A (ADJ-PLA) patients were administered QTer 300 mg and Vit A acetate 500.000 Ul/g 1 mg twice daily for a 4-week intervention period, followed by a 4-week period of wash-out, and then were submitted to a last 4-week period of placebo. Patients in Group B (PLB-ADJ) were given the treatment period in reverse order. Both groups received a 45-min voice therapy in a group format once a day for 4 weeks during the first and the second active periods. The therapy was held during the wash-out period. Results: The analysis of main time effect indicated a trend toward recovery of vocal function regardless of group assignment. A significant time by group effect was found on DSI [F = 3.4 (2.5, 80.5), p = 0.03], F0-high [F = 4.5 (2.6, 82.9), p = 0.008] and Shimmer [F = 3.6 (1.5, 46.9), p = 0.048], under CoQ10 and Vit A treatment, with a small effect size. There was no significant time by group effect on the other study measures, namely MPT, I-low, VHI. Conclusions: A trend toward recovery of vocal function was observed in all the patients, likely due to voice rehabilitation. The improvement of DSI was greater under CoQ10 and Vitamin treatment, indicating a more pronounced improvement of vocal quality under adjuvant therapy. The study protocol was reviewed and approved by the Ethics Committee of Policlinico Umberto I Hospital, Rome, Italy Rif. 3069/13.02.2014

Village Baseline Study: Site Analysis Report for Yabello – Borana, Ethiopia

The village baseline of Denbela Saden village in the CCAFS benchmark site of Yabello in Ethiopia took place from 10th to 12th August 2011. Focus group discussions were conducted separately for men and women. Denbela Saden is a Borana pastoralist village located in a semi-arid area where the dominant vegetation is grass, scrub and acacia trees. It faces inadequate and low quality pasture due to encroachment by bushes, livestock overstocking, and human settlement, all related to a government policy of encouraging permanent settlement of the pastoralists as opposed to the former system of nomadism. The increasing population and the settlement of the community have amplified the need for crop cultivation to complement weakened pastoral production. Cultivation is dependent on often inadequate and unreliable rainfall, and takes place in the valley beds. Crop residues are not incorporated into the soil but used to feed animals. Not surprisingly, yields are very low. Government agricultural extension services do not add much value to cultivators because they focus on livestock services in this area. Two parallel governance systems co-exist in Denbela Saden village, namely the traditional customary system and the modern government system, and the challenge is to create a win–win situation where the operations of these systems are synchronized. The government describes the area as chronically food insecure, and it is not surprising that more than half of the 16 groups/organisations working in the region address food security issues

Why is it some households fall into poverty at the same time others are escaping poverty? Evidence from Kenya

Presents study carried out to evaluate how different households have fared over time in the communities. The aim of the study was to determine the proportions of households that Why is it some households fall into poverty at the same time others are escaping poverty? The study presents results from a study of poverty dynamics across Kenya using a participatory poverty assessment methodology known as the ‘Stages of Progress Methodology.’ This method is a relatively rapid, effective and participatory way to learn about poverty processes at both community and household levels. The approach generates very useful information for identifying the poor, and for understanding the factors that push people into and pull them out of poverty. Using this methodology, the typical stages through which people progress out of poverty were elicited for 71 Kenyan communities and 4773 households. The discussion of the different stages, and the order in which they occur, provoked lively debate among assembled villagers. The findings show that in virtually all 71 communities, house-holds progress out of poverty first by acquiring food, followed by obtaining adequate clothing, making improvements in their shelter, securing primary education for their children, starting small businesses. The paper presents the results of recent investigations, carried out specifically to gain knowledge about the reasons underlying poverty. Reasons for escape and reasons for descent operating in each livelihood region of Kenya were identified through a careful examination of poverty dynamics

The conundrum of conservation agriculture and livelihoods in Southern Africa

Low crop productivity, food insecurity, hunger and malnutrition; inadequate farming knowledge and skills, implements and inputs are characteristic of smallholder agriculture in Southern Africa. Many researchers argue that conservation agriculture can guarantee higher crop productivity, food security, improved livelihoods and environmental protection, better than the unsustainable traditional systems of slash and burn practices. In this paper, we present the results of a meta-analysis of over 40 academic publications to review conservation agriculture's role in influencing desired livelihood outcomes in Southern Africa. We conclude that the effectiveness of conservation agriculture towards better livelihood outcomes in Southern Africa remains debatable, especially when supportive government policies are lacking. (Résumé d'auteur

Village Baseline Study: Site Analysis Report for Kagera Basin – Rakai, Uganda

The village baseline study of Kyengeza village in the CCAFS site Kagera Basin – Rakai in Uganda took place from 4 to 6 July 2011. Study participants are aware that their food security depends on protecting and appropriately managing natural resources. Nonetheless, there is a general decline in the state of natural resources such as rivers, lakes and forests, and the current use of the same resources is not sustainable over time. The main drivers of such changes in the region are population growth and government policies that have privatised forests and other natural areas previously managed by the village, effectively disempowering the community. There are more organisations operating beyond the locality than those operating in the community. The external organisations started delivering food, tools, medicines and other resources in response to HIV/AIDS. Their ability to mobilise resources, however, is undermining self-help capacity within the village, which is not conducive to sustainable rural development. Radio and organisations are the most frequently used sources of information for agricultural decision- making. There is a relatively active information network compared to other CCAFS sites, and a fair amount of consultation with all kinds of sources of information. This may be linked to high levels of uncertainty associated with climate change and food security

Retrieval Lesson Learned from NAST-I Hyperspectral Data

The retrieval lesson learned is important to many current and future hyperspectral remote sensors. Validated retrieval algorithms demonstrate the advancement of hyperspectral remote sensing capabilities to be achieved with current and future satellite instruments

Search for the Hypothetical pi -> mu x Decay

The KARMEN collaboration has reported the possible observation of a hitherto unknown neutral and weakly interacting particle x, which is produced in the decay pi -> mu + x with a mass m(x) = 33.9 MeV. We have searched for this hypothetical decay branch by studying muons from pion decay in flight with the LEPS spectrometer at the piE3 channel at PSI and find branching ratios BR(pi- to mu- anti-x) < 4e-7 and BR(pi+ to mu+ x) < 7e-8 (95\% C.L.). Together with the limit BR > 2e-8 derived in a recent theoretical paper our result would leave only a narrow region for the existence of x if it is a heavy neutrino.Comment: 10 pages, TeX (uses epsf), 3 Postscript figures uu-encode