Customer empowerment in tourism through Consumer Centric Marketing (CCM)

We explain Consumer Centric Marketing (CCM) and adopt this new technique to travel context. Benefits and disadvantages of the CCM are outlined together with warnings of typical caveats Value: CCM will be expected as the norm in the travel industry by customers of the future, yet it is only the innovators who gain real tangible benefits from this development. We outline current and future opportunities to truly place your customer at the centre and provide the organisation with some real savings/gains through the use of ICT Practical Implications: We offer tangible examples for travel industry on how to utilise this new technology. The technology is already available and the ICT companies are keen to establish ways how consumers can utilise it, i.e. by providing ‘content’ for these ICT products the travel industry can fully gain from these developments and also enhance consumers’ gains from it. This can result in more satisfied customers for the travel (as well as ICT) companies thus truly adopting the basic philosophy of marketin

Data analysis of 3He gas-filled detectors

Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2022, Tutors: Ariel Esteban Tarifeño Saldivia, Volodymyr K MagasA Digital Pulse Analysis method has been developed and tested for 3He gas-filled neutron counters using fast digitizers. The method is needed for the calibration of high pilled-up events in pulsed proton beams. By this procedure identification and reconstruction of events are suit for digital signal processing methods that maintain and add flexibility in front of traditional-analog method

Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715

Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and poses a vulnerability that can be exploited therapeutically. The spindle assembly checkpoint (SAC) ensures correct chromosome-microtubule attachment, thereby minimizing chromosome segregation errors. Many tumors exhibit upregulation of SAC components such as MPS1, which may help contain CIN within survivable limits. Prior studies showed that MPS1 inhibition with the small molecule NMS-P715 limits tumor growth in xenograft models. In cancer cell lines, NMS-P715 causes cell death associated with impaired SAC function and increased chromosome missegregation. Although normal cells appeared more resistant, effects on stem cells, which are the dose-limiting toxicity of most chemotherapeutics, were not examined. Elevated expression of 70 genes (CIN70), including MPS1, provides a surrogate measure of CIN and predicts poor patient survival in multiple tumor types. Our new findings show that the degree of CIN70 upregulation varies considerably among PDAC tumors, with higher CIN70 gene expression predictive of poor outcome. We identified a 25 gene subset (PDAC CIN25) whose overexpression was most strongly correlated with poor survival and included MPS1. In vitro, growth of human and murine PDAC cells is inhibited by NMS-P715 treatment, whereas adipose-derived human mesenchymal stem cells are relatively resistant and maintain chromosome stability upon exposure to NMS-P715. These studies suggest that NMS-P715 could have a favorable therapeutic index and warrant further investigation of MPS1 inhibition as a new PDAC treatment strategy

Evaluation Research and Institutional Pressures: Challenges in Public-Nonprofit Contracting

This article examines the connection between program evaluation research and decision-making by public managers. Drawing on neo-institutional theory, a framework is presented for diagnosing the pressures and conditions that lead alternatively toward or away the rational use of evaluation research. Three cases of public-nonprofit contracting for the delivery of major programs are presented to clarify the way coercive, mimetic, and normative pressures interfere with a sound connection being made between research and implementation. The article concludes by considering how public managers can respond to the isomorphic pressures in their environment that make it hard to act on data relating to program performance.This publication is Hauser Center Working Paper No. 23. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers

Physiological Measures of Risk Perception in Highly Automated Driving

Highly automated driving will likely result in drivers being out-of-the-loop during specific scenarios and engaging in a wide range of non-driving related tasks. Manifesting in lower levels of risk perception to emerging events, and thus affect drivers' availability to take-over manual control in safety-critical scenarios. In this empirical research, we measured drivers' (N = 20) risk perception with cardiac and skin conductance indicators through a series of high-fidelity, simulated highly automated driving scenarios. By manipulating the presence of surrounding traffic and changing driving conditions as long-term risk modulators, and including a driving hazard event as a short-term risk modulator, we hypothesised that an increase in risk perception would induce greater physiological arousal. Our results demonstrate that heart rate variability features are superior at capturing arousal variations from these long-term, low to moderate risk scenarios. In contrast, skin conductance responses are more sensitive to rapidly evolving situations associated with moderate to high risk. Based on this research, future driver state monitoring systems should adopt multiple physiological measures to capture changes in the long and short term, modulation of risk perception. This will enable enhanced perception of driver readiness and improved availability to safely deal with take-over events when requested by an automated vehicle.</p

Using fNIRS to Verify Trust in Highly Automated Driving

Trust in automation is crucial for the safe and appropriate adoption of automated driving technology. Current research methods to measure trust mainly rely on subjective scales, with several intrinsic limitations. This empirical experiment proposes a novel method to measure trust objectively, using functional near-infrared spectroscopy (fNIRS). Through manipulating participants’ expectations regarding driving automation credibility, we have induced and successfully measured opposing levels of trust in automation. Most notably, our results evidence two separate yet interrelated cortical mechanisms for trust and distrust. Trust is demonstrably linked to decreased monitoring and working memory, whereas distrust is event-related and strongly tied to affective (or emotional) mechanisms. This paper evidence that trust in automation and situation awareness are strongly interrelated during driving automation usage. Our findings are crucial for developing future driver state monitoring technology that mitigates the impact of inappropriate reliance, or over trust, in automated driving systems

Sushi in the United States, 1945-1970

Sushi first achieved widespread popularity in the United States in the mid-1960s. Many accounts of sushi’s US establishment foreground the role of a small number of key actors, yet underplay the role of a complex web of large-scale factors that provided the context in which sushi was able to flourish. This article critically reviews existing literature, arguing that sushi’s US popularity arose from contingent, long-term, and gradual processes. It examines US newspaper accounts of sushi during 1945–1970, which suggest the discursive context for US acceptance of sushi was considerably more propitious than generally acknowledged. Using California as a case study, the analysis also explains conducive social and material factors, and directs attention to the interplay of supply- and demand-side forces in the favorable positioning of this “new” food. The article argues that the US establishment of sushi can be understood as part of broader public acceptance of Japanese cuisine

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Cognitive Training with Modern Board and Card Games in Healthy Older Adults: Two Randomized Controlled Trials

Objectives. The aim of this study was to assess the effectiveness of a cognitive intervention based on modern board and card games. Methods. We conducted two two-arm parallel-group, randomized controlled trials. The first one (pilot study) was non-blind. The second one (main study) was a doubleblind design. Participants (14 in a pilot study and 35 in the main study) were healthy older adults over 65 years old who were assisting to adult care institutions. In the pilot study, participants in the experimental group (n=6) played modern board and card games which activated cognitive processes; whereas the control group (n=6) was in the wait-list condition. In the main study, participants in the experimental group (n=12) also played modern board and card games; whereas the control group (n=15) performed standardized paper-and-pencil cognitive tasks. Psychologists specialized in older-people conducted all the interventions. In both studies, intervention sessions were bi-weekly for 5 weeks. The outcomes of both studies were cognitive status and executive functioning, depressive symptomatology, and quality of life measures. All assessment and intervention sessions took place in their habitual centers. Results. In the pilot study, participants in the games intervention showed a significant improvement in semantic verbal fluency. In the main study, both interventions showed significant improvements in phonemic verbal fluency. Whilst board and card games maintained motor impulsivity control, paper-and-pencil tasks improved speed in an inhibition task. Conclusions. Modern board and card games could be an effective cognitive intervention to maintain some cognitive functions.We would like to express our gratitude to the participants, the centers (Balàfia I and II, and Comtes Urgell) and all their workers. Thanks to the Comissionat per a Universitats i Recerca del DIUE, Generalitat de Catalunya (2017SGR1577), to the Center for Biomedical Research Network on Mental Health (CIBERSAM), and to Spanish Ministry of Science, Innovation and Universities (MICIU/FEDER; project RTI2018‐099800‐B‐I00)