[Budget Impact Analysis of the Adjuvanted Quadrivalent Influenza Vaccine in the Elderly in Italy]

BACKGROUND: Vaccination is the most effective way to prevent influenza and its complications. The MF59-adjuvanted quadrivalent (aQIV) and the high-dose quadrivalent (QIV-HD) influenza vaccines have been specifically developed to protect subjects aged ≥65 years. The aim of this study was to evaluate the economic consequences associated with the use of aQIV in the elderly population in Italy.METHODS: An Excel-based budget impact model was developed to estimate the costs of aQIV for the prevention of influenza and its complications in elderly subjects, from the perspective of the Italian National Health Service. In the base-case analysis a current scenario (with aQIV) was compared with a past scenario (without aQIV), in which only the standard quadrivalent influenza vaccine (QIV-STD) was available. In the scenario analysis, a current scenario was compared with a future (hypothetical) scenario, in which the market share of aQIV grows. Efficacy (or effectiveness) data of vaccines, in terms of reduction of influenza-related deaths and hospitalizations for influenza/pneumonia, respiratory, and cardiac complications, were obtained from the scientific literature. Relative effectiveness of aQIV and QIV-HD vs. QIV-STD in preventing laboratory-confirmed influenza cases came from two meta-analysis of real-world studies. Epidemiological data and unit costs are collected from Italian published sources.RESULTS: In the base-case analysis the introduction of aQIV e QIV-STD was associated with a reduction of influenza and influenza-like illness – ILI (-93,171) cases, hospitalization for influenza, respiratory and cardiovascular complications (-6,823), and deaths (-1,841) and a consequent saving of € 1.9 million and € 24 million related to events and hospital admissions avoided, respectively. In the scenario analysis, the growth of the market shares of aQIV was associated with 13,602 fewer cases of influenza and ILI, 996 fewer hospitalizations, and an overall saving equal to € 3.8 million.CONCLUSIONS: aQIV reduces the number of cases of influenza and ILI, hospitalizations for influenza and respiratory or cardiac complications, and deaths in the Italian population aged ≥65 years

Fatigue performance of recycled hot mix asphalt: A laboratory study

The paper introduces and analyses the results of an experimental trial on the fatigue resistance of recycled hot mix asphalt for road pavements. Based on the gyratory compaction and the indirect tensile strength test, the mix design procedure has optimized nine different mixes, considering both conventional limestone and Reclaimed Asphalt Pavement (RAP), the latter used at different quantities, up to 40% by weight of the aggregate. A standard bitumen and two polymer modified binders were used for the production of the mixes. The fatigue study was carried out with four-point bending tests, each one performed at 20\ub0C and 10 Hz. The empirical stiffness reduction method, along with the energy ratio approach, based on the dissipated energy concept, was adopted to elaborate the experimental data. Unaged and aged specimens were checked, to analyse the ageing effects on the fatigue performance. In comparison with the control mixes, produced only with limestone, improved fatigue performance was noticed for the mixtures prepared with RAP, especially when made with polymer modified binders, under both aged and unaged conditions. Both the approaches adopted for the experimental data analysis have outlined the same ranking of the mixes

Zinc oxide nanoparticles based microfluidic immunosensor applied in congenital hypothyroidism screening

In this article, we present an innovative approach for congenital hypothyroidism (CHT) screening. This pathology is the most common preventable cause of mental retardation, affecting newborns around the world. Its consequences could be avoided with an early diagnosis through the thyrotropin (TSH) level measurement. To accomplish the determination of TSH, synthesized zinc oxide (ZnO) nanobeads (NBs) covered by chitosan (CH), ZnO-CH NBs, were covalently attached to the central channel of the designed microfluidic device. These beads were employed as platform for anti-TSH monoclonal antibody immobilization to specifically recognize and capture TSH in neonatal samples without any special pretreatment. Afterwards, the amount of this trapped hormone was quantified by horseradish peroxidase (HRP)-conjugated anti-TSH antibody. HRP reacted with its enzymatic substrate in a redox process, which resulted in the appearance of a current whose magnitude was directly proportional to the level of TSH in the neonatal sample. The structure and morphology of synthesized ZnO-CH NBs were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The calculated detection limits for electrochemical detection and the enzyme-linked immunosorbent assay procedure were 0.00087 μUI mL-1 and 0.015 μUI mL-1, respectively, and the within- and between-assay coefficients of variation were below 6.31 % for the proposed method. According to the cut-off value for TSH neonatal screening, a reasonably good limit of detection was achieved. These above-mentioned features make the system advantageous for routine clinical analysis adaptation.Fil: Seia, Marco Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Pereira, Sirley Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: de Vito, Irma Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Messina, Germán Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentin

An Extension of the ns-3 LTE Module to Simulate Fractional Frequency Reuse Algorithms

We developed an extension for the LTE module of the ns-3 simulator in order to allow the simulation of Fractional Frequency Reuse algorithms and the evaluation of their performance in an LTE scenario. In this paper, we describe the technical components of such extension, namely the new API for Fractional Frequency Reuse algorithms, the implementation of several state-of-the-art-algorithms based on such API, and the implementation of the LTE downlink and uplink power control functionality which are required by many of these algorithms. Additionally, we provide an overview of the test suites that are included with our extension in order to validate its correct functionality, and discuss some example scenarios illustrating how our extension can be used in an LTE simulation

analysis of the mechanical behaviour of asphalt concretes using artificial neural networks

The current paper deals with the numerical prediction of the mechanical response of asphalt concretes for road pavements, using artificial neural networks (ANNs). The asphalt concrete mixes considered in this study have been prepared with a diabase aggregate skeleton and two different types of bitumen, namely, a conventional bituminous binder and a polymer-modified one. The asphalt concretes were produced both in a road materials laboratory and in an asphalt concrete production plant. The mechanical behaviour of the mixes was investigated in terms of Marshall stability, flow, quotient, and moreover by the stiffness modulus. The artificial neural networks used for the numerical analysis of the experimental data, of the feedforward type, were characterized by one hidden layer and 10 artificial neurons. The results have been extremely satisfactory, with coefficients of correlation in the testing phase within the range 0.98798–0.91024, depending on the considered model, thus demonstrating the feasibility to apply ANN modelization to predict the mechanical and performance response of the asphalt concretes investigated. Furthermore, a closed-form equation has been provided for each of the four ANN models developed, assuming as input parameters the production process, the bitumen type and content, the filler/bitumen ratio, and the volumetric properties of the mixes. Such equations allow any other researcher to predict the mechanical parameter of interest, within the framework of the present study

Functionalization of Pyrene To Prepare Luminescent Materials—Typical Examples of Synthetic Methodology

Pyrene-based π-conjugated materials are considered to be an ideal organic electro-luminescence material for application in semiconductor devices, such as organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs) and organic photovoltaics (OPVs), and so forth. However, the great drawback of employing pyrene as an organic luminescence material is the formation of excimer emission, which quenches the efficiency at high concentration or in the solid-state. Thus, in order to obtain highly efficient optical devices, scientists have devoted much effort to tuning the structure of pyrene derivatives in order to realize exploitable properties by employing two strategies, 1) introducing a variety of moieties at the pyrene core, and 2) exploring effective and convenient synthetic strategies to functionalize the pyrene core. Over the past decades, our group has mainly focused on synthetic methodologies for functionalization of the pyrene core; we have found that formylation/acetylation or bromination of pyrene can selectly lead to functionalization at K-region by Lewis acid catalysis. Herein, this Minireview highlights the direct synthetic approaches (such as formylation, bromination, oxidation, and de-tert-butylation reactions, etc.) to functionalize the pyrene in order to advance research on luminescent materials for organic electronic applications. Further, this article demonstrates that the future direction of pyrene chemistry is asymmetric functionalization of pyrene for organic semiconductor applications and highlights some of the classical asymmetric pyrenes, as well as the latest breakthroughs. In addition, the photophysical properties of pyrene-based molecules are briefly reviewed. To give a current overview of the development of pyrene chemistry, the review selectively covers some of the latest reports and concepts from the period covering late 2011 to the present day

Fatigue Performance of Recycled Hot Mix Asphalt: A Laboratory Study

The paper introduces and analyses the results of an experimental trial on the fatigue resistance of recycled hot mix asphalt for road pavements. Based on the gyratory compaction and the indirect tensile strength test, the mix design procedure has optimized nine different mixes, considering both conventional limestone and Reclaimed Asphalt Pavement (RAP), the latter used at different quantities, up to 40% by weight of the aggregate. A standard bitumen and two polymer modified binders were used for the production of the mixes. The fatigue study was carried out with four-point bending tests, each one performed at 20 ∘ C and 10 Hz. The empirical stiffness reduction method, along with the energy ratio approach, based on the dissipated energy concept, was adopted to elaborate the experimental data. Unaged and aged specimens were checked, to analyse the ageing effects on the fatigue performance. In comparison with the control mixes, produced only with limestone, improved fatigue performance was noticed for the mixtures prepared with RAP, especially when made with polymer modified binders, under both aged and unaged conditions. Both the approaches adopted for the experimental data analysis have outlined the same ranking of the mixes

Development of a Bio-Mathematical Crew Fatigue Model for Business Aviation Operators

Against the backdrop of the current aviation accident trend which poses human factor as their main cause, pilot fatigue is a pivotal issue which may jeopardize mission safety. At current times, the development of a Fatigue Risk Management System (FRMS) for Business Aviation Operators (BAOs) is not required by EASA, albeit already mandatory according to UK and FAA regulations. The aim of this paper is to present a Bio-Mathematical crew fatigue model which can assist BAOs in the creation of a proper FRMS, based on objective science-based biological models. The already challenging conditions linked to the evaluation of fatigue are compounded by the conditions which BAOs are affected by: 24-hour-a-day activities, night flights, irregular and unpredictable flight schedules, extended wakefulness and changes of time zone. Factors such as these challenge human physiology and can lead to performance-impairing fatigue and increased risks to safety. The lack of instrumental examination providing an objective value of fatigue status makes it difficult to get a complete picture of the crew’s mental and physical state. This paper describes the main underlying elements employed in the model creation and how the model has been adapted for BAOs specific requirements. The model is backed up by simple however effective algebraic relationships which take into consideration several influences leveraging pre-existing scales: prediction of alertness, cumulative fatigue duty time and sub-standard sleep quality

Short‐term biogeomorphology of a gravel‐bed river: Integrating remote sensing with hydraulic modelling and field analysis

In recent decades, fluvial geomorphology and ecohydraulic research have extensively used field observations, remote sensing or hydrodynamic modelling to understand river systems. This study presents an innovative approach that combines field surveys, Light Detection and Ranging (LiDAR)-based topographical and biomass analyses and model-derived hydro-morphodynamic geostatistics to examine short-term bio-geomorphological changes in the wandering gravel-bed Orco River in Italy. Our primary hypothesis is that hydro-morphological variables can be robust descriptors for riparian vegetation distribution. From a geomorphological perspective, our study con-firms the prevalent wandering behaviour of the Orco River. Moreover, we identified a widening trend in braiding and anabranching sections, particularly downstream.This is evident because of hotspots of flood-induced morphological reactivation and the redistribution of sediments from the riverbed to lateral bars, resulting in a multi-thread pattern. Our analysis reveals a net increase in biomass during the observation period despite frequent flood disturbances. We attributed it to two opposing bio-geomorphological dynamics: the reduced flow disturbance in some regions due to flood-induced geomorphological changes and the self-healing of lateral connectivity through river wandering. Such a net increase indicates that transitional rivers store carbon in the form of vegetation biomass due to their short-term morphological instability and the different timescales between vegetation and morphological adjustments. Finally, we supported our initial hypothesis with three key findings: (i) a signature of vegetation not just on topography but also on hydro-morphological conditions, summarised by inundation probability; (ii) the lower variance in vertical topographical changes in vegetated areas compared with bare ones; and (iii) the introduction of a new parameter, named inundation viscosity, derived from the product of mean bed shear stress and average inundation duration, as a discriminating factor for colonisation conditions. These results underscore the value of our comprehensive approach