From 3D Models to 3D Prints: an Overview of the Processing Pipeline

Due to the wide diffusion of 3D printing technologies, geometric algorithms for Additive Manufacturing are being invented at an impressive speed. Each single step, in particular along the Process Planning pipeline, can now count on dozens of methods that prepare the 3D model for fabrication, while analysing and optimizing geometry and machine instructions for various objectives. This report provides a classification of this huge state of the art, and elicits the relation between each single algorithm and a list of desirable objectives during Process Planning. The objectives themselves are listed and discussed, along with possible needs for tradeoffs. Additive Manufacturing technologies are broadly categorized to explicitly relate classes of devices and supported features. Finally, this report offers an analysis of the state of the art while discussing open and challenging problems from both an academic and an industrial perspective.Comment: European Union (EU); Horizon 2020; H2020-FoF-2015; RIA - Research and Innovation action; Grant agreement N. 68044

The Milky Way like galaxy NGC 6384 and its nuclear star cluster at high NIR spatial resolution using LBT/ARGOS commissioning data

We analyse high spatial resolution near infra-red (NIR) imaging of NGC6384, a Milky Way like galaxy, using ARGOS commissioning data at the Large Binocular Telescope (LBT). ARGOS provides a stable PSF$_{\rm FWHM}\!=\!0.2"\!-\!0.3"$ AO correction of the ground layer across the LUCI2 NIR camera $4'\!\times4'$ field by using six laser guide stars (three per telescope) and a natural guide star for tip-tilt sensing and guiding. Enabled by this high spatial resolution we analyse the structure of the nuclear star cluster (NSC) and the central kiloparsec of NGC6384. We find via 2D modelling that the NSC ($r_{\rm eff}\!\simeq\!10$pc) is surrounded by a small ($r_{\rm eff}\!\simeq\!100$pc) and a larger Sersi\'c ($r_{\rm eff}\!\simeq\!400$pc), all embedded within the NGC\,6384 large-scale boxy/X-shaped bulge and disk. This proof-of-concept study shows that with the high spatial resolution achieved by ground-layer AO we can push such analysis to distances previously only accessible from space. SED-fitting to the NIR and optical HST photometry allowed to leverage the age-metallicity-extinction degeneracies and derive the effective NSC properties of an young to old population mass ratio of $8\%$ with ${\cal M}_{\rm\star,old}\!\simeq\!3.5\times10^7M_\odot$, Age$_{\rm old,\ young}\!=\!10.9\pm1.3$Gyr and 226\,Myr$\pm62\%$, metallicity [M/H]$=\!-0.11\pm0.16$and$0.33\pm39\%$dex, and$E(B\!-\!V)\!=\!0.63$ and 1.44mag.Comment: 12 pages (+9 appendix), 11 figures, Accepted in MNRA

Social marketing and healthy eating : Findings from young people in Greece

This document is the Accepted Manuscript version. The final publication is available at Springer via http://dx.doi.org/10.1007/s12208-013-0112-xGreece has high rates of obesity and non-communicable diseases owing to poor dietary choices. This research provides lessons for social marketing to tackle the severe nutrition-related problems in this country by obtaining insight into the eating behaviour of young adults aged 18–23. Also, the main behavioural theories used to inform the research are critically discussed. The research was conducted in Athens. Nine focus groups with young adults from eight educational institutions were conducted and fifty-nine participants’ views towards eating habits, healthy eating and the factors that affect their food choices were explored. The study found that the participants adopted unhealthier nutritional habits after enrolment. Motivations for healthy eating were good health, appearance and psychological consequences, while barriers included lack of time, fast-food availability and taste, peer pressure, lack of knowledge and lack of family support. Participants reported lack of supportive environments when deciding on food choices. Based on the findings, recommendations about the development of the basic 4Ps of the marketing mix, as well as of a fifth P, for Policy are proposedPeer reviewe

A SOCIO-TECHNICAL PERSPECTIVE ON REPRODUCIBILITY IN RESEARCH DATA MANAGEMENT

The Open Science paradigm has brought the dissemination of experimental artifacts on the agenda of funding agencies, research institutions, and academic publishers. Managing research data is a crucial part of guaranteeing the reusability and reproducibility of published results. In this research, we suggest a conceptualization of reproducibility based on threats, risks, and vulnerabilities identified in current research data management (RDM) practices. By doing so, we can describe a range of threats to reproducibility and pinpoint areas where current RDM practices and the scholarly communication infrastructure insufficiently address these threats. Further, we elaborate on a socio-technical approach to reproducibility in RDM by collecting evidence from researchers and scientific publications. We show that the STS approach complements current IS research on RDM by offering a holistic view of reproducibility challenges in RDM

Streamlining Cross-Organizational Aircraft Development: Results from the AGILE Project

The research and innovation AGILE project developed the next generation of aircraft Multidisciplinary Design and Optimization processes, which target significant reductions in aircraft development costs and time to market, leading to more cost-effective and greener aircraft solutions. The high level objective is the reduction of the lead time of 40% with respect to the current state-of-the-art. 19 industry, research and academia partners from Europe, Canada and Russia developed solutions to cope with the challenges of collaborative design and optimization of complex products. In order to accelerate the deployment of large-scale, collaborative multidisciplinary design and optimization (MDO), a novel methodology, the so-called AGILE Paradigm, has been developed. Furthermore, the AGILE project has developed and released a set of open technologies enabling the implementation of the AGILE Paradigm approach. The collection of all the technologies constitutes AGILE Framework, which has been deployed for the design and the optimization of multiple aircraft configurations. This paper focuses on the application of the AGILE Paradigm on seven novel aircraft configurations, proving the achievement of the project’s objectives

Impacts of climate change on plant diseases – opinions and trends

There has been a remarkable scientific output on the topic of how climate change is likely to affect plant diseases in the coming decades. This review addresses the need for review of this burgeoning literature by summarizing opinions of previous reviews and trends in recent studies on the impacts of climate change on plant health. Sudden Oak Death is used as an introductory case study: Californian forests could become even more susceptible to this emerging plant disease, if spring precipitations will be accompanied by warmer temperatures, although climate shifts may also affect the current synchronicity between host cambium activity and pathogen colonization rate. A summary of observed and predicted climate changes, as well as of direct effects of climate change on pathosystems, is provided. Prediction and management of climate change effects on plant health are complicated by indirect effects and the interactions with global change drivers. Uncertainty in models of plant disease development under climate change calls for a diversity of management strategies, from more participatory approaches to interdisciplinary science. Involvement of stakeholders and scientists from outside plant pathology shows the importance of trade-offs, for example in the land-sharing vs. sparing debate. Further research is needed on climate change and plant health in mountain, boreal, Mediterranean and tropical regions, with multiple climate change factors and scenarios (including our responses to it, e.g. the assisted migration of plants), in relation to endophytes, viruses and mycorrhiza, using long-term and large-scale datasets and considering various plant disease control methods

De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas

Introduction: The SOX gene family consists of twenty transcription factors that play a pivotal role in cell fate and differentiation during the development of many organ systems. Within these SRY-related (SOX) genes is a highly conserved high mobility group (HMG) domain that has been shown to be critical for DNA binding and bending, nuclear trafficking, and protein-protein interactions. Mutations within this transcription factor family have been associated with rare congenital disorders, known as SOXopathies. These mutations are commonly de novo, heterozygous and inactivating, and exhibit gene haploinsufficiency. Of these twenty transcription factors, SOX6 is known to be involved in chondrocyte differentiation and development of the central nervous system. Although there have been reports of SOX6 variants causing adult pathological conditions, there has yet to be a well-established association between SOX6 variants and a developmental syndrome. Objectives: The objective of this study was to use clinical and genetic data to examine SOX6 mutations found in 19 individuals demonstrating developmental delay and to test the transcriptional activity of the 4 missense variants in vitro to determine if SOX6 haploinsufficiency leads to a neurodevelopmental SOXopathy. Methods: Nineteen individuals were identified as carriers of SOX6 variants, confirmed by molecular karyotyping, whole-exome sequencing, or whole-genome sequencing. Clinical pathogenicity was predicted and assessed in silico and in vitro. Expression plasmids for SOX6 missense variants were generated by PCR mutagenesis. The four missense variants generated were: p.Trp161Cys, p.Met605Thr, p.Trp639Arg, and p.Ser746Leu, with p.Met605Thr and p.Trp639Arg located within the HMG domain. For reporter assays, HEK293 cells were transfected in triplicate cultures with 3.5 µL ViaFect Transfection Reagent and a total of 1000ng of DNA. SOX6 intracellular localization was tested by transfecting either HEK293 or COS-1 cells and cytoplasmic and nuclear extracts were prepared for Western Blot analysis. Whole cell extracts transfected with respective WT-SOX6 or variant plasmid were also prepared for a dimerization assay. SOX6’s ability to bind DNA was also tested in an electrophoretic mobility shift assay (EMSA). Results: Study cohort consisted of 19 individuals from 17 unrelated families originating in Belgium, Canada, France, Germany, the Netherlands, Slovenia, the UK, and the US. These individuals shared milestone delays and intellectual disability, and exhibited abnormalities including mild dysmorphism, craniosynostosis, and osteochondromas. Immunoblots of nuclear and cytoplasmic extracts showed all variants were efficiently expressed however p.Met605Thr and p.Trp639Arg were not translocated or retained into the nucleus as efficiently as WT-SOX6 and the other two missense variants. The EMSA showed that proteins outside of the HMG domain behaved like WT-SOX6, but p.Met605Thr and p.Trp639Arg failed to bind the DNA probe. Reporter assay activity showed that the two variants outside of the HMG domain p.Trp161Cys and p.Ser746Leu displayed similar or slightly higher activity compared to WT-SOX6 while the two variants p.Met605Thr and p.Trp639Arg showed diminished reporter activity. Conclusions: These findings provide evidence that SOX6 variants cause a SOXopathy, which has been designated in Online Mendelian Inheritance in Man (OMIM) as #618971 Tolchin-Le Caignec syndrome (TOLCAS)

Procedural bridges-and-pillars support generation

International audienceAdditive manufacturing requires support structures to fabricate parts with overhangs. In this paper, we revisit a known support structure based on bridges-and-pillars. The support structures are made of vertical pillars supporting horizontal bridges. Their scaffolding structure makes them stable and reliable to print. However, the algorithm heuristic search does not scale well and is prone to produce contacts with the parts, leaving scars after removal. We propose a novel algorithm for this type of supports, focusing on avoiding unnecessary contacts with the part as much as possible. Our approach builds upon example-based model synthesis to enable early detection of collision-free passages as well as non-reachable regions

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Regional jet retrofitting design: from stakeholders’ needs and system’s requirements to MDAO workflow formulation

n this paper, a process useful for the verification of economic, environmental and performance requirements related to the retrofit of 90 passengers regional jet aircraft is described. The requirements are defined according to the stakeholders’ needs involved in the process. Multiple scenarios are put in place, ranging from environmental restrictions to volatility of fuel price, aircraft fleet to be retrofitted to passengers’ comfort level. Two retrofitting packages are considered: the re-engining of conventional power-plant platform with advanced geared turbofan and the on-board-system modernization, considering different level of electrification. Starting from the definition of the architectures, which represent the starting and the target points of the design, a multidisciplinary collaborative aircraft design workflow is generated and executed to analyze the retrofit solutions. Results coming from the disciplinary competences introduced for the analysis are exploited to verify the fulfilment of profits, costs, performance, and emission requirements. The overall process is implemented in the framework of the AGILE 4.0 research project, moving towards a thorough Model Based System Engineering problem definition