Flavor and CP violation in Higgs decays

Flavor violating interactions of the Higgs boson are a generic feature of models with extended electroweak symmetry breaking sectors. Here, we investigate CP violation in these interactions, which can arise from interference of tree-level and 1-loop diagrams. We compute the CP asymmetry in flavor violating Higgs decays in an effective field theory with only one Higgs boson and in a general Type-III Two Higgs Doublet Model (2HDM). We find that large (~ O(10%)) asymmetries are possible in the 2HDM if one of the extra Higgs bosons has a mass similar to the Standard Model Higgs. For the poorly constrained decay modes h -> tau mu and h -> tau e, this implies that large lepton charge asymmetries could be detectable at the LHC. We quantify this by comparing the sensitivity of the LHC to existing direct and indirect constraints. Interestingly, detection prospects are best if Higgs mixing is relatively small - a situation that is preferred by the current data. Nevertheless, CP violation in h -> tau mu or h -> tau e will only be observable if nonzero rates for these decay modes are measured very soon.Comment: 17 pages, 5 figure

Hint of Lepton Flavour Non-Universality in BB Meson Decays

The LHCb collaboration has recently presented their result on R_K = BR(B+ -> K+ mu+ mu-)/ BR(B+ -> K+ e+ e-) for the dilepton invariant mass bin m_{ll}^2 = 1-6 GeV^2 (l = mu, e). The measurement shows an intriguing 2.6 sigma deviation from the Standard Model (SM) prediction. In view of this, we study model independent New Physics (NP) explanations of R_K consistent with other measurements involving b -> s l l transition, relaxing the assumption of lepton universality. We perform a Bayesian statistical fit to the NP Wilson Coefficients and compare the Bayes Factors of the different hypotheses in order to quantify their goodness-of-fit. We show that the data slightly favours NP in the muon sector over NP in the electron sector.Comment: Final version, to appear in JHE

Gravitino Dark Matter and low-scale Baryogenesis

A very simple way to obtain comparable baryon and DM densities in the early Universe is through their contemporary production from the out-of-equilibrium decay of a mother particle, if both populations are suppressed by comparably small numbers, i.e. the CP violation in the decay and the branching fraction respectively. We present a detailed study of this kind of scenario in the context of a R-parity violating realization of the MSSM in which the baryon asymmetry and the gravitino Dark Matter are produced by the decay of a Bino. The implementation of this simple picture in a realistic particle framework results, however, quite involving, due to the non trivial determination of the abundance of the decaying Bino, as well as due to the impact of wash-out processes and of additional sources both for the baryon asymmetry and the DM relic density. In order to achieve a quantitative determination of the baryon and Dark Matter abundances, we have implemented and solved a system of coupled Boltzmann equations for the particle species involved in their generation, including all the relevant processes. In the most simple, but still general, limit, in which the processes determining the abundance and the decay rate of the Bino are mediated by degenerate right-handed squarks, the correct values of the DM and baryon relic densities are achieved for a Bino mass between 50 and 100 TeV, Gluino NLSP mass in the range 15-60 TeV and a gravitino mass between 100 GeV and few TeV. These high masses are unfortunately beyond the kinematical reach of LHC. On the contrary, an antiproton signal from the decays of the gravitino LSP might be within the sensitivity of AMS-02 and gamma-ray telescopes.Comment: 39 pages, 12 figure

Accidental matter at the LHC

We classify weak-scale extensions of the Standard Model which automatically preserve its accidental and approximate symmetry structure at the renormalizable level and which are hence invisible to low-energy indirect probes. By requiring the consistency of the effective field theory up to scales of 10^15 GeV and after applying cosmological constraints, we arrive at a finite set of possibilities that we analyze in detail. One of the most striking signatures of this framework is the presence of new charged and/or colored states which can be efficiently produced in high-energy particle colliders and which are stable on the scale of detectors.Comment: 55 pages, 13 figure

Constraining new coloured matter from the ratio of 3- to 2-jets cross sections at the LHC

The Large Hadron Collider experiments are probing the evolution of the strong coupling $\alpha_s$ up to the TeV scale. We show how the ratio of 3- to 2-jets cross sections is affected by the presence of new physics and argue that it can be used to place a model-independent bound on new particles carrying QCD color charge. The current data potentially constrains such states to be heavier than a few hundred GeVs.Comment: 9 pages, 7 figure

On-glass optoelectronic platform for on-chip detection of DNA

Lab-on-chip are analytical systems which, compared to traditional methods, offer significant reduction of sample, reagent, energy consumption and waste production. Within this framework, we report on the development and testing of an optoelectronic platform suitable for the on-chip detection of fluorescent molecules. The platform combines on a single glass substrate hydrogenated amorphous silicon photosensors and a long pass interferential filter. The design of the optoelectronic components has been carried out taking into account the spectral properties of the selected fluorescent molecule. We have chosen the [Ru(phen)2(dppz)]2+ which exhibits a high fluorescence when it is complexed with nucleic acids in double helix. The on-glass optoelectronic platform, coupled with a microfluidic network, has been tested in detection of double-stranded DNA (dsDNA) reaching a detection limit as low as 10 ng/μL

An all-glass microfluidic network with integrated amorphous silicon photosensors for on-chip monitoring of enzymatic biochemical assay

A lab-on-chip system, integrating an all-glass microfluidics and on-chip optical detection, was developed and tested. The microfluidic network is etched in a glass substrate, which is then sealed with a glass cover by direct bonding. Thin film amorphous silicon photosensors have been fabricated on the sealed microfluidic substrate preventing the contamination of the micro-channels. The microfluidic network is then made accessible by opening inlets and outlets just prior to the use, ensuring the sterility of the device. The entire fabrication process relies on conventional photolithographic microfabrication techniques and is suitable for low-cost mass production of the device. The lab-on-chip system has been tested by implementing a chemiluminescent biochemical reaction. The inner channel walls of the microfluidic network are chemically functionalized with a layer of polymer brushes and horseradish peroxidase is immobilized into the coated channel. The results demonstrate the successful on-chip detection of hydrogen peroxide down to 18 mu M by using luminol and 4-iodophenol as enhancer agent

Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria

We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID). Male ENU2 mice showed increased mGlu5 receptor protein levels in the hippocampus and corpus striatum (but not in the prefrontal cortex) whereas the transcript of the mGlu5 receptor was unchanged. No changes in mGlu1 receptor mRNA and protein levels were found in any of the three brain regions of ENU2 mice. We extended the analysis to Homer proteins, which act as scaffolds by linking mGlu1 and mGlu5 receptors to effector proteins. Expression of the long isoforms of Homer was significantly reduced in the hippocampus of ENU2 mice, whereas levels of the short Homer isoform (Homer 1a) were unchanged. mGlu5 receptors were less associated to immunoprecipitated Homer in the hippocampus of ENU2 mice. The lack of mGlu5 receptor-mediated long-term depression (LTD) in wild-type mice (of BTBR strain) precluded the analysis of hippocampal synaptic plasticity in ENU2 mice. We therefore performed a behavioral analysis to examine whether pharmacological blockade of mGlu5 receptors could correct behavioral abnormalities in ENU2 mice. Using the same apparatus we sequentially assessed locomotor activity, object exploration, and spatial object recognition (spatial novelty test) after displacing some of the objects from their original position in the arena. Systemic treatment with the mGlu5 receptor antagonist, MPEP (20 mg/kg, i.p.), had a striking effect in the spatial novelty test by substantially increasing the time spent in exploring the displaced objects in ENU2 mice (but not in wild-type mice). These suggest a role for mGlu5 receptors in the pathophysiology of ID in PKU and suggest that, also in adult untreated animals, cognitive dysfunction may be improved by targeting these receptors with an appropriate therapy