ILCD Data Network and ELCD Database: current use and further needs for supporting Environmental Footprint and Life Cycle Indicator Projects.

The aim of this report is to investigate the current use and needs of the ILCD DN and of the ELCD supporting the EF and the LC Indicator projects providing a coherent data basis increasing usability and consistent application in the European context. Some recommended future development have been investigated and reported as well in this report.JRC.H.8-Sustainability Assessmen

Environmental Footprint and Material Efficiency Support for Product Policy - Feasibility study for a standardized method to measure the time taken to extract certain parts from an Electrical and Electronic Equipment

A study of the Joint Research Centre – JRC- on material efficiency published in 2012 established a method for the identification and assessment of “hot-spots” for End-of-Life (EoL) treatments of Waste Electric and Electronic Equipment (WEEE), including television, washing machines and imaging equipment. The method has been since then applied to various other product groups (e.g. enterprise servers). The improved extractability of target parts in Energy related Products (ErP) can represent a potential suitable requirement in the context of Ecodesign Directive for various product groups. In the case of measures for the “design for extraction of target parts in ErP” the 2012 JRC study identified the “time for the extraction” as a good proxy to prove the ‘easiness to disassembly’. However, the verification of the application of measures on extractability implies the availability of a method for repeatable measurements. The present report intends to provide scientific evidences on the feasibility of defining extraction times for the disassembly of WEEE and how it should be structured. The development of a standardised method for measuring the time for extraction of product’s target parts should allow the repeatability of measurements and minimizing uncertainty by removing or decreasing the influence of uncontrolled experimental conditions. The report includes a review of the relevant scientific references (including standards and scientific articles), discusses key issues for the measurement of the ‘time for extraction’ of product’s target parts and proposes how such keys issues can be integrated in an exemplary method for the measurement. Key definitions to be provided in the measurement method have been identified and provided for the following terms: target parts, extraction, extraction sequence, extraction time, worker experience, and tools for the extraction of components/parts. This report also establishes possible operating conditions such as testing area and safety requirements to extract parts of WEEE. The dismantling sequence has been identified as a crucial aspect. Detailed provisions on the dismantling sequence have been provided. The testing dismantling sequence has to be pre-defined prior to the product dismantling. Finally, a proposed measurement method has been developed as proof of concept and it is attached in Appendix 1. The method has been structured in order to reflect the framework of a potential international standard.JRC.H.8-Sustainability Assessmen

Coexistence of a generalist owl with its intraguild predator: distance-sensitive or habitat-mediated avoidance?

Intraguild predation is increasingly reported as a population-limiting factor for vertebrate predators. However, long-term coexistence of the intraguild prey with its predator is a common occurrence usually maintained by some form of predator avoidance, which may be achieved through distance-sensitive avoidance (selection of sites as far as possible from the intraguild predator), and/or habitat-mediated avoidance (avoidance of habitats associated with high predation risk). The former is expected when the distribution of the predator is heterogeneous, leaving gaps which can be exploited by the prey, while the latter is expected at high predator densities, when few predation refugia are available. To date, few studies have focused on such switch in predator avoidance under changing scenarios of intraguild predator density. To test this hypothesis, we censused tawny owls (Strix aluco, body mass ∼0.4-0.7 kg) and their intraguild predator, the eagle owl (Bubo bubo, ∼1.5-4 kg), in 12 areas of the Alps. As predicted, tawny owls were indifferent to predator distance in an area of low predation risk, they switched to distance-sensitive avoidance in an area of medium predator density and to habitat-mediated avoidance in an area of high predator density with few available refugia. Actual predation rates were low, but increased with proximity to the intraguild predator nest. Similarly, tawny owl breeding output declined with closeness to an eagle owl nest. Habitat loss associated with predator avoidance translated into population effects, leading to a negative relationship between the densities of the two owl species. The spatial gaps in tawny owl distribution caused by eagle owls indirectly favoured other owl species, resulting in higher diversity of the overall owl community and suggesting that eagle owls acted as keystone predators. Our results suggest that intraguild predation may alter habitat choices and affect density, productivity and guild structure of vertebrate mesopredators. Such effects are probably more common than previously thought. © 2007 The Association for the Study of Animal Behaviour.Peer Reviewe

Potential of life cycle assessment for supporting the management of critical raw materials

Resource security is a policy concern which has been recently addressed in several initiatives of the European Commission. Based on supply risk and economic importance, a list of Critical Raw Materials (CRM) has been identified for the European economy, in order to prioritize policy actions. Resource use has been the object of the sustainability science from its dawn. Current sustainability assessment methodologies focus on accounting resource flows (e.g. Material Flow Analysis) or on scarcity issues (e.g. in Life Cycle Assessment, LCA). Factors that could constrain the access to resources are usually overlooked. The paper illustrates how resources are currently addressed in the sustainability assessment methodologies, and how CRMs are identified. It explores the potential of LCA in providing information on CRMs at different levels: considering the flows of CRMs in supply chains at inventory level, including criticality criteria (e.g. supply risk) in the impact assessment, and analysing the flows of CRMs at macro-economic scale within the framework of Life Cycle Indicators. The research gaps and the open issues regarding the assessment of resources in LCA are highlighted.JRC.H.8 - Sustainability Assessmen

Challenges and opportunities for web-shared publication of quality-assured life cycle data: the contributions of the Life Cycle Data Network

Purpose: The European Commission’s Integrated Product Policy Communication, 2003, defined Life Cycle Assessment (LCA) as the ‘best framework for assessing the potential environmental impacts of products’. Since then, the use of LCA and life cycle approaches has been developing in a wide range of European policies, and its use has also significantly grown in business. Increasing the availability of quality-assured Life Cycle Inventory (LCI) data is the current challenge to ensure the development of LCA in various areas. Methods: One solution to increase availability is to use LCI data from multiple database sources but under the condition that such LCI data are fully interoperable. Results and discussion: This paper presents original solutions and recent achievements towards increased availability, quality and interoperability of life cycle inventory data, developed through European Commission-led activities and based on wide stakeholder consultation and international dialogue. An overview of related activities, such as the International Reference Life Cycle Data System (ILCD), the European Reference Life Cycle Database (ELCD) and the ILCD Entry-Level quality requirements are presented. The focus is then on the Life Cycle Data Network (LCDN). Conclusions: A non-centralised data network of LCI datasets complying with minimum quality requirements that was politically launched in February 2014, already includes several database nodes from different worldwide sources and has the potential to contribute to the needs of the international community

A Video Game Based on Optimal Control and Elementary Statistics

The video game presented in this paper is a prey-predator game where two preys (human players) must avoid three predators (automated players) and must reach a location in the game field (the computer screen) called preys' home. The game is a sequence of matches and the human players (preys) must cooperate in order to achieve the best perform- ance against their opponents (predators). The goal of the predators is to capture the preys, which are the predators try to have a "rendez vous" with the preys, using a small amount of the "resources" available to them. The score of the game is assigned following a set of rules to the prey team, not to the individual prey. In some situations the rules imply that to achieve the best score it is convenient for the prey team to sacrifice one of his components. The video game pursues two main purposes. The first one is to show how the closed loop solution of an optimal control problem and elementary sta- tistics can be used to generate (game) actors whose movements satisfy the laws of classical mechanics and whose be- haviour simulates a simple form of intelligence. The second one is "educational", in fact the human players in order to be successful in the game must understand the restrictions to their movements posed by the laws of classical mechanics and must cooperate between themselves. The video game has been developed having in mind as players for children aged between five and thirteen years. These children playing the video game acquire an intuitive understanding of the basic laws of classical mechanics (Newton's dynamical principle) and enjoy cooperating with their teammate. The video game has been experimented on a sample of a few dozen children. The children aged between five and eight years find the game amusing and after playing a few matches develop an intuitive understanding of the laws of classical me- chanics. They are able to cooperate in making fruitful decisions based on the positions of the preys (themselves), of the predators (their opponents) and on the physical limitations to the movements of the game actors. The interest in the game decreases when the age of the players increases. The game is too simple to interest a teenager. The game engine consists in the solution of an assignment problem, in the closed loop solution of an optimal control problem and in the adaptive choice of some parameters. At the beginning of each match, and when necessary during a match, an assign- ment problem is solved, that is the game engine chooses how to assign to the predators the preys to chase. The resulting assignment implies some cooperation among the predators and defines the optimal control problem used to compute the strategies of the predators during the match that follows. These strategies are determined as the closed loop solution of the optimal control problem considered and can be thought as a (first) form of artificial intelligence (AI) of the preda- tors. In the optimal control problem the preys and the predators are represented as point masses moving according to Newton's dynamical principle under the action of friction forces and of active forces. The equations of motion of these point masses are the constraints of the control problem and are expressed through differential equations. The formula- tion of the decision process through optimal control and Newton's dynamical principle allows us to develop a game where the effectiveness and the goals of the automated players can be changed during the game in an intuitive way sim- ply modifying the values of some parameters (i.e. mass, friction coefficient, ...). In a sequence of game matches the predators (automated players) have "personalities" that try to simulate human behaviour. The predator personalities are determined making an elementary statistical analysis of the points scored by the preys in the game matches played and consist in the adaptive choice of the value of a parameter (the mass) that appears in the differential equations that define the movements of the predators. The values taken by this parameter determine the behaviour of the predators and their effectiveness in chasing the preys. The predators personalities are a (second) form of AI based on elementary statistics that goes beyond the intelligence used to chase the preys in a match. In a sequence of matches the predators using this second form of AI adapt their behaviour to the preys' behaviour. The video game can be downloaded from the website: http://www.ceri.uniroma1.it/ceri/zirilli/w10/

Rethinking the Area of Protection “Natural Resources” in Life Cycle Assessment

Life cycle impact assessment (LCIA) in classical life cycle assessment (LCA) aims at analyzing potential impacts of products and services typically on three so-called areas of protection (AoPs): Natural Environment, Human Health, and Natural Resources. This paper proposes an elaboration of the AoP Natural Resources. It starts with analyzing different perspectives on Natural Resources as they are somehow sandwiched in between the Natural Environment (their cradle) and the human-industrial environment (their application). Reflecting different viewpoints, five perspectives are developed with the suggestion to select three in function of classical LCA. They result in three safeguard subjects: the Asset of Natural Resources, their Provisioning Capacity, and their role in Global Functions. Whereas the Provisioning Capacity is fully in function of humans, the global functions go beyond provisioning as they include nonprovisioning functions for humans and regulating and maintenance services for the globe as a whole, following the ecosystem services framework. A fourth and fifth safeguard subject has been identified: recognizing the role Natural Resources for human welfare, either specifically as building block in supply chains of products and services as such, either with or without their functions beyond provisioning. But as these are far broader as they in principle should include characterization of mechanisms within the human industrial society, they are considered as subjects for an integrated sustainability assessment (LCSA: life cycle sustainability assessment), that is, incorporating social, economic and environmental issues

Optimising subjective grading of corneal staining in Sjögren's syndrome dry eye disease

Aim: To assess whether smaller increment and regionalised subjective grading improves the repeatability of corneal fluorescein staining assessment, and to determine the neurological approach adopted for subjective grading by practitioners. Methods: Experienced eye-care practitioners (n = 28, aged 45 ± 12 years), graded 20 full corneal staining images of patients with mild to severe Sjögren's syndrome with the Oxford grading scheme (both in 0.5 and 1.0 increments, globally and in 5 regions), expanded National Eye Institute (NEI) and SICCA Ocular Staining Score (OSS) grading scales in randomised order. This was repeated after 7–10 days. The digital images were also analysed objectively to determine staining dots, area, intensity and location (using ImageJ) for comparison. Results: The Oxford grading scheme was similar with whole and half unit grading (2.77vs2.81,p = 0.145), but the variability was reduced (0.14vs0.12,p < 0.001). Regional grade was lower (p < 0.001) and more variable (p < 0.001) than global image grading (1.86 ± 0.44 for whole increment grading and 1.90 ± 0.39 for half unit increments). The correlation with global grading was high for both whole (r = 0.928,p < 0.001) and half increment (r = 0.934,p < 0.001) grading. Average grading across participants was associated with particle number and vertical position, with 74.4–80.4% of the linear variance accounted for by the digital image analysis. Conclusions: Using half unit increments with the Oxford grading scheme improve its sensitivity and repeatability in recording corneal staining. Regional grading doesn't give a comparable score and increased variability. The key neurally extracted features in assigning a subjective staining grade by clinicians were identified as the number of discrete staining locations (particles) and how close to the vertical centre was their spread, across all three scales

A study protocol for identifying aging trajectories toward chronic neurodegenerative diseases by means of Marche regional administrative databases – TREND project

BackgroundPeople are living longer but an increasing number of older people experience chronicity and disability in the latest years of their life. The Marche region is one of the Italian regions where people live the longest lives; therefore, the number of people with age-related chronic diseases is expected to be at least similar, if not higher, compared to the rest of Italy. The identification of the aging trajectories is of huge interest in the arena of public health. Administrative healthcare databases represent valuable reservoirs for reconstructing the trajectories of aging. Here, we present the protocol for a study (TREND project) aimed to integrate existing administrative databases into a Marche regional dataset in order to estimate the prevalence and incidence rates of age-related neurodegenerative diseases (ND), with a specific focus on Parkinsonism and Dementia.MethodsThe TREND Project is a retrospective cross-sectional study. The source population includes permanent residents in the Marche region aged 40 years and older. A minimal dataset has been built up linking data on drug prescriptions, outpatient services, and diagnosis for hospital admission, from 2014 to 2021 in the Marche Region. Data on clinical outcomes (re-hospitalization, mortality, comorbidities), and therapeutic approaches (drugs and medicines) have been integrated with state-of-the-art statistical methods to define patients into different risk clusters and to analyze the aging trend by assessing the Comorbidity Index (CI) as a proxy for chronicity.DiscussionOur research contributes to the integration of existing administrative databases on ND to create a Marche regional ND database, support regional health policy, and better understand patients’ needs and their aging trajectories. This approach could be implemented also at the National level. Moreover, by linking different administrative data sources, this study sheds light on important issues related to ND, such as early-onset dementia; ethical aspects such as anticipated wills; problems of dementia in patients still in the job market, etc. The results of this study will contribute to the successful implementation of integrated care for patients affected by ND at regional or national levels

Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality

none28noThe stratification of mortality risk in COVID-19 patients remains extremely challenging for physicians, especially in older patients. Innovative minimally invasive molecular biomarkers are needed to improve the prediction of mortality risk and better customize patient management. In this study, aimed at identifying circulating miRNAs associated with the risk of COVID-19 in-hospital mortality, we analyzed serum samples of 12 COVID-19 patients by small RNA-seq and validated the findings in an independent cohort of 116 COVID-19 patients by qRT-PCR. Thirty-four significantly deregulated miRNAs, 25 downregulated and 9 upregulated in deceased COVID-19 patients compared to survivors, were identified in the discovery cohort. Based on the highest fold-changes and on the highest expression levels, 5 of these 34 miRNAs were selected for the analysis in the validation cohort. MiR-320b and miR-483-5p were confirmed to be significantly hyper-expressed in deceased patients compared to survived ones. Kaplan-Meier and Cox regression models, adjusted for relevant confounders, confirmed that patients with the 20% highest miR-320b and miR-483-5p serum levels had three-fold increased risk to die during in-hospital stay for COVID-19. In conclusion, high levels of circulating miR-320b and miR-483-5p can be useful as minimally invasive biomarkers to stratify older COVID-19 patients with an increased risk of in-hospital mortality.restrictedGiuliani, Angelica; Matacchione, Giulia; Ramini, Deborah; Di Rosa, Mirko; Bonfigli, Anna Rita; Sabbatinelli, Jacopo; Monsurrò, Vladia; Recchioni, Rina; Marcheselli, Fiorella; Marchegiani, Francesca; Piacenza, Francesco; Cardelli, Maurizio; Galeazzi, Roberta; Pomponio, Giovanni; Ferrarini, Alessia; Gabrielli, Armando; Baroni, Silvia Svegliati; Moretti, Marco; Sarzani, Riccardo; Giordano, Piero; Cherubini, Antonio; Corsonello, Andrea; Antonicelli, Roberto; Procopio, Antonio Domenico; Ferracin, Manuela; Bonafè, Massimiliano; Lattanzio, Fabrizia; Olivieri, FabiolaGiuliani, Angelica; Matacchione, Giulia; Ramini, Deborah; Di Rosa, Mirko; Bonfigli, Anna Rita; Sabbatinelli, Jacopo; Monsurrò, Vladia; Recchioni, Rina; Marcheselli, Fiorella; Marchegiani, Francesca; Piacenza, Francesco; Cardelli, Maurizio; Galeazzi, Roberta; Pomponio, Giovanni; Ferrarini, Alessia; Gabrielli, Armando; Baroni, Silvia Svegliati; Moretti, Marco; Sarzani, Riccardo; Giordano, Piero; Cherubini, Antonio; Corsonello, Andrea; Antonicelli, Roberto; Procopio, Antonio Domenico; Ferracin, Manuela; Bonafè, Massimiliano; Lattanzio, Fabrizia; Olivieri, Fabiol