Az ipari parkok a területi versenyképességben: telephelyek vagy fejlesztési csomópontok?

The MATLAB/C program take version 3.1 is a program for simulation of X-ray projections from 3D volume data. It is based on an older C version by Muller-Merbach as well as an extended C version by Turbell. The program can simulate 2D X-ray projections from 3D objects. These data can then be input to 3D reconstruction algorithms. Here however, we only demonstrate a couple of 2D reconstruction algorithms, written in MATLAB. Simple MATLAB examples show how to generate the take projections followed by subsequent reconstruction. Compared to the old take version, the C code have been carefully revised. A preliminary, rather untested feature of using a polychromatic X-ray source with different energy levels was already included in the old take version. The current polychromatic feature X-ray is however carefully tested. For example, it has been compared with the results from the program described by Malusek et al. We also demonstrate experiments with a polychromatic X-ray source and a Plexiglass object giving the beam-hardening artefact. Detector sensitivity for different energy levels is not included in take. However, in section~\refsec:realexperiment, we describe a technique to include the detector sensitivity into the energy spectrum. Finally, an experiment with comparison of real and simulated data were performed. The result wasn't completely successful, but we still demonstrate it. Contemporary analytical reconstruction methods for helical cone-beam CT have to be designed to handle the Long Object Problem. Normally, a moderate amount of over-scanning is sufficient for reconstruction of a certain Region-of-interest (ROI). Unfortunately, for iterative methods, it seems that the useful ROI will diminish for every iteration step. The remedies proposed here are twofold. Firstly, we use careful extrapolation and masking of projection data. Secondly, we generate and utilize projection data from incompletely reconstructed volume parts, which is rather counter-intuitive and contradictory to our initial assumptions. The results seem very encouraging. Even voxels close to the boundary in the original ROI are as well enhanced by the iterative loop as the middle part

Fuel on the Invention Funnel: Technology Licensing-in, Antecedents and Invention

In this paper, we examine the impact of technology licensing-in on firm invention performance. Studying a sample of 266 licensees and matched non-licensees using a two-part model specification, we find that licensees are more likely to introduce inventions than their non-licensee counterparts. This holds both if we consider invention in general, and invention in the licensed technological class only. We also show that familiarity with the licensed technology and technological specialization drives licensees to pursue a narrow invention strategy primarily focusing on the technological class specified in the license agreement.Licensing-in, Invention, Dynamic Capabilities, Learning Opportunities, Technological familiarity, Technological specialization

Fuel on the Invention Funnel: Technology Licensing-in, Antecedents and Invention

Technology management has so far largely overlooked that licensing-in may represent learning opportunities for the recipient firm. Attention has primarily been directed towards a more tactic explanation for the decision of firms to in-license external technologies. However, increasing empirical evidence witnesses an inducing effect of licensing-in on the inventive behavior of the single firm which, in turn, feeds its development and growth. The aim of this paper is to explore whether licensing-in in fact acts as a catalyst for inventive activities pursued by licensee firms. We employ a two-part model to investigate the inventiveness of 133 licensees compared to an equally sized matched sample of non-licensees. The study reveals that licensees exhibit elevated invention performances compared to non-licensee counterparts. This holds both when considering invention in general and invention in licensed technological class.. In addition, the paper reveals that familiarity with the licensed technology and technological specialization instigates the licensee to pursue a narrow invention strategy as defined by the technological classes of the licensed patent.Technology management has so far largely overlooked that licensing-in may represent learning opportunities for the recipient firm. Attention has primarily been directed towards a more tactic explanation for the decision of firms to in-license external technologies. However, increasing empirical evidence witnesses an inducing effect of licensing-in on the inventive behavior of the single firm which, in turn, feeds its development and growth. The aim of this paper is to explore whether licensing-in in fact acts as a catalyst for inventive activities pursued by licensee firms. We employ a two-part model to investigate the inventiveness of 133 licensees compared to an equally sized matched sample of non-licensees. The study reveals that licensees exhibit elevated invention performances compared to non-licensee counterparts. This holds both when considering invention in general and invention in licensed technological class.. In addition, the paper reveals that familiarity with the licensed technology and technological specialization instigates the licensee to pursue a narrow invention strategy as defined by the technological classes of the licensed patent.Non-Refereed Working Papers / of national relevance onl

Protein crystals in adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis

Intranuclear crystalline inclusions have been observed in the nucleus of epithelial cells infected with Adenovirus serotype 5 (Ad5) at late steps of the virus life cycle. Using immuno-electron microscopy and confocal microscopy of cells infected with various Ad5 recombinants modified in their penton base or fiber domains, we found that these inclusions represented crystals of penton capsomers, the heteromeric capsid protein formed of penton base and fiber subunits. The occurrence of protein crystals within the nucleus of infected cells required the integrity of the fiber knob and part of the shaft domain. In the knob domain, the region overlapping residues 489–492 in the FG loop was found to be essential for crystal formation. In the shaft, a large deletion of repeats 4 to 16 had no detrimental effect on crystal inclusions, whereas deletion of repeats 8 to 21 abolished crystal formation without altering the level of fiber protein expression. This suggested a crucial role of the five penultimate repeats in the crystallisation process. Chimeric pentons made of Ad5 penton base and fiber domains from different serotypes were analyzed with respect to crystal formation. No crystal was found when fiber consisted of shaft (S) from Ad5 and knob (K) from Ad3 (heterotypic S5-K3 fiber), but occurred with homotypic S3K3 fiber. However, less regular crystals were observed with homotypic S35-K35 fiber. TB5, a monoclonal antibody directed against the Ad5 fiber knob was found by immunofluorescence microscopy to react with high efficiency with the intranuclear protein crystals in situ. Data obtained with Ad fiber mutants indicated that the absence of crystalline inclusions correlated with a lower infectivity and/or lower yields of virus progeny, suggesting that the protein crystals might be involved in virion assembly. Thus, we propose that TB5 staining of Ad-infected 293 cells can be used as a prognostic assay for the viability and productivity of fiber-modified Ad5 vectors

Evaluation of Ammonia as a Potential Marine Fuel

Alternative marine fuels are needed to mitigate emissions from the shipping sector in order to fulfil climate targets set by the International Maritime Organisation. This study assesses the potential of ammonia as a fuel for shipping compared to other alternative marine fuels by conducting energy systems modelling by the global energy transition (GET) model and a multi-criteria decision analysis (MCDA) with stakeholder preference taken into account. This contributes to an initial assessment of cost-effective fuel choices in the shipping sector and what marine fuel that is preferred when assessing economic, environmental, social and technical impacts with weights of criteria provided by stakeholders. Besides ammonia, the alternative marine fuels considered in this study are: liquefied natural gas (LNG), hydrogenated vegetable oil (HVO), methanol (MeOH) and hydrogen (H2). The GET model perform simulations with constraints of the atmospheric CO2 concentration that must be fulfilled by year 2100. Two scenarios of different constraints, 450 ppm and 550 ppm CO2, are conducted with results stating that the most cost-effective shipping fuels at the end of the studied time period are H2 and LNG in combination with fuel cells (FC) as propulsion technology. Ammonia is cost-effective as a shipping fuel under both constraints but only to a limited extent. In the MCDA other criteria than economic performance are introduced and the evaluation is performed by the Analytic Hierarchy Process. Eleven fuel options are included in the MCDA, combining different feedstocks, production methods and propulsion technologies; internal combustion engine (ICE) or fuel cell (FC). There are four ammonia options included representing if ammonia is produced from either electrolysis based or natural gas based hydrogen and combined with either ICEs or FCs. The MCDA results in a ranking where the most preferred fuel option is hydrogen produced by electrolysis and combined with FC. Ammonia combined with FCs also perform well and end up in 2nd and 4th place, while the ammonia options with ICEs are found in the bottom of the ranking in 9th and 11th place. The results of this thesis implies that several alternative marine fuels show potential, however further assessments are needed to draw firm conclusions about the potential of ammonia as an alternative marine fuel

Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts

OBJECTIVE: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies. DESIGN: We conducted a GWA study (GWAS) of IBS in a general population sample of 11\u2005326 Swedish twins. IBS cases (N=534) and asymptomatic controls (N=4932) were identified based on questionnaire data. Suggestive association signals were followed-up in 3511 individuals from six case-control cohorts. We sought genotype-gene expression correlations through single nucleotide polymorphism (SNP)-expression quantitative trait loci interactions testing, and performed in silico prediction of gene function. We compared candidate gene expression by real-time qPCR in rectal mucosal biopsies of patients with IBS and controls. RESULTS: One locus at 7p22.1, which includes the genes KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and GRID2IP (glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein), showed consistent IBS risk effects in the index GWAS and all replication cohorts and reached p=9.31 710(-6) in a meta-analysis of all datasets. Several SNPs in this region are associated with cis effects on KDELR2 expression, and a trend for increased mucosal KDLER2 mRNA expression was observed in IBS cases compared with controls. CONCLUSIONS: Our results demonstrate that general population-based studies combined with analyses of patient cohorts provide good opportunities for gene discovery in IBS. The 7p22.1 and other risk signals detected in this study constitute a good starting platform for hypothesis testing in future functional investigations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

Supervising Student Independence

This open access book examines the supervision of undergraduate degree projects, with a particular focus on how supervision may contribute to developing student independence and academic literacies. Based on an extensive research project, it uses examples from focus group interviews as well as actual supervision situations, taken from different higher education programmes at several universities in Sweden and Russia. The authors discuss issues such as supervisors’ perceptions and understandings of student independence, the relationship between supervisor and student, the significance of emotions in the supervision process, different supervision tools to foster independence, and the supervisor’s role not only as a guide and helper but also as an assessor of the students’ work. The book will appeal to scholars within the field of teaching and learning in higher education, as well as those from other disciplines who are interested in developing their own supervision practice

Rarity of monodominance in hyperdiverse Amazonian forests.

Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inventory plots from the Amazon Tree Diversity Network (ATDN). Utilizing a simple defining metric of at least half of the trees ≥ 10 cm diameter belonging to one species, we found only a few occurrences of monodominance in Amazonia, and the phenomenon was not significantly linked to previously hypothesized life history traits such wood density, seed mass, ectomycorrhizal associations, or Rhizobium nodulation. In our analysis, coppicing (the formation of sprouts at the base of the tree or on roots) was the only trait significantly linked to monodominance. While at specific locales coppicing or ectomycorrhizal associations may confer a considerable advantage to a tree species and lead to its monodominance, very few species have these traits. Mining of the ATDN dataset suggests that monodominance is quite rare in Amazonia, and may be linked primarily to edaphic factors

Associations between birth size and later height from infancy through adulthood : an individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight

Scientific Opinion on the pest categorisation of Eotetranychus lewisi

The Panel on Plant Health performed a pest categorisation of the Lewis spider mite, Eotetranychus lewisi, for the European Union (EU). The Lewis spider mite is a well-defined and distinguishable pest species that has been reported from a wide range of hosts, including cultivated species. Its distribution in the EU territory is restricted to (i) Madeira in Portugal; and to (ii) Poland where few occurrences were reported in glasshouses only. The pest is listed in Annex IIAI of Council Directive 2000/29/EC. A potential pathway of introduction and spread is plants traded from outside Europe and between Member States. The Lewis spider mite has the potential to establish in most part of the EU territory based on climate similarities with the distribution area outside the EU and the widespread availability of hosts present both in open fields and in protected cultivations. With regards to the potential consequences, one study is providing quantitative data on impact showing that the pest can reduce yield and affect quality of peaches and poinsettias, and only few studies describe the general impact of the pest on cultivated hosts. Although chemical treatments are reported to be effective in controlling the Lewis spider mite, it is mentioned as a growing concern for peaches, strawberries, raspberries and vines in the Americas. Overall, Eotetranychus lewisi meets the pest categorisation criteria defined in the International Standards for Phytosanitary Measures No 11 for a quarantine pest and in No 21 for a regulated non-quarantine pest