Stable Hebbian learning from spike timing-dependent plasticity

We explore a synaptic plasticity model that incorporates recent findings that potentiation and depression can be induced by precisely timed pairs of synaptic events and postsynaptic spikes. In addition we include the observation that strong synapses undergo relatively less potentiation than weak synapses, whereas depression is independent of synaptic strength. After random stimulation, the synaptic weights reach an equilibrium distribution which is stable, unimodal, and has positive skew. This weight distribution compares favorably to the distributions of quantal amplitudes and of receptor number observed experimentally in central neurons and contrasts to the distribution found in plasticity models without size-dependent potentiation. Also in contrast to those models, which show strong competition Changes in the synaptic connections between neurons are widely believed to contribute to memory storage, and the activitydependen

An islanding detection method for multi-DG systems based on high-frequency impedance estimation

Active islanding detection methods are generally employed for grid-connected inverter-based Distributed Generation (DG). However, there might be mutual influences and power quality issues caused by the disturbance signal when multiple inverters are involved. To address those problems, this paper analyzes the potential failure mechanism of the f-Q (frequency-reactive power) drifting active method in multiple-DG situations. Then, a novel high frequency transient injection based islanding detection method that is suitable for both single and multiple-DGs is proposed. Compared with the conventional injection methods, a high frequency impedance model for DG is provided for better theoretical analysis. By means of the intermittent Time Domain Low Voltage Condition (TDLVC) injection control, this method can achieve good accuracy and reduce disturbances to power system

Ubiquitous text interaction

Computer-based interactions increasingly pervade our everyday environments. Be it on a mobile device, a wearable device, a wall-sized display, or an augmented reality device, interactive systems often rely on the consumption, composition, and manipulation of text. The focus of this workshop is on exploring the problems and opportunities of text interactions that are embedded in our environments, available all the time, and used by people who may be constrained by device, situation, or disability. This workshop welcomes all researchers interested in interactive systems that rely on text input or output. Participants should submit a short position statement outlining their background, past work, future plans, and suggesting a use-case they would like to explore in-depth during the workshop. During the workshop, small teams will form around common or compelling use-cases. Teams will spend time brainstorming, creating low-fidelity prototypes, and discussing their use-case with the group. Participants may optionally submit a technical paper for presentation as part of the workshop program. The workshop serves to sustain and build the community of text entry researchers who attend CHI. It provides an opportunity for new members to join this community, soliciting feedback from experts in a small and supportive environment

Advanced DC zonal marine power system protection

A new Active Impedance Estimation (AIE) based protection strategy which is suitable for utilization in a DC zonal marine power distribution system is presented. This method uses two triangular current "spikes" injections for system impedance estimation and protection when faults are detected. By comparing the estimated impedance with the pre-calibrated value, the fault location can be predicted and fault can be isolated without requiring communication between two injection units. Using co¬operated double injections and line current measurement (directional fault detection), faults in the system with same impedance and different fault positions can be distinguished, located and isolated. The proposed method is validated using experimental test results derived from a 30kW, 400V, twin bus DC marine power system demonstrator. The experimental tests were applied to both faults during normal operation and faults that occur during system restoration

Pressure Support vs. Thermal Broadening in the Lyman-alpha Forest II: Effects of the Equation of State on Transverse Structure

We examine the impact of gas pressure on the transverse coherence of high-redshift (2 <= z <= 4) Lyman-alpha forest absorption along neighboring lines of sight that probe the gas Jeans scale (projected separation Delta r <= 500 kpc/h comoving; angular separation Delta theta <= 30"). We compare predictions from two smoothed particle hydrodynamics (SPH) simulations that have different photoionization heating rates and thus different temperature-density relations in the intergalactic medium (IGM). We also compare spectra computed from the gas distributions to those computed from the pressureless dark matter. The coherence along neighboring sightlines is markedly higher for the hotter, higher pressure simulation, and lower for the dark matter spectra. We quantify this coherence using the flux cross-correlation function and the conditional distribution of flux decrements as a function of transverse and line-of-sight (velocity) separation. Sightlines separated by Delta theta <= 15" are ideal for probing this transverse coherence. Higher pressure decreases the redshift-space anisotropy of the flux correlation function, while higher thermal broadening increases the anisotropy. In contrast to the longitudinal (line-of-sight) structure of the Lya forest, the transverse structure on these scales is dominated by pressure effects rather than thermal broadening. With the rapid recent growth in the number of known close quasar pairs, paired line-of-sight observations offer a promising new route to probe the IGM temperature-density relation and test the unexpectedly high temperatures that have been inferred from single sightline analyses.Comment: 11 figures, submitted to MNRA

Pressure Support vs. Thermal Broadening in the Lyman-alpha Forest I: Effects of the Equation of State on Longitudinal Structure

In the low density intergalactic medium (IGM) that gives rise to the Lyman-alpha forest, gas temperature and density are tightly correlated. The velocity scale of thermal broadening and the Hubble flow across the gas Jeans scale are of similar magnitude (Hlambda_J ~ sigma_th). To separate the effects of gas pressure support and thermal broadening on the Lya forest, we compare spectra extracted from two smoothed particle hydrodynamics (SPH) simulations evolved with different photoionization heating rates (and thus different Jeans scales), imposing different temperature-density relations on the evolved particle distributions. The turnover scales in the flux power spectrum and flux autocorrelation function are determined mainly by thermal broadening rather than pressure. However, the insensitivity to pressure arises partly from a cancellation effect with a sloped temperature-density relation (T ~ rho^{0.6} in our simulations): the high density peaks in the colder, lower pressure simulation are less smoothed by pressure support than in the hotter simulation, and it is this higher density gas that experiences the strongest thermal broadening. Changes in thermal broadening and pressure support have comparably important effects on the flux probability distribution (PDF), which responds directly to the gas overdensity distribution rather than the scale on which it is smooth. Tests on a lower resolution simulation show that our statistical results are converged even at this lower resolution. While thermal broadening generally dominates the longitudinal structure in the Lya forest, we show in Paper II that pressure support determines the transverse coherence of the forest observed towards close quasar pairs. [ABRIDGED]Comment: 12 figures, MNRAS in pres

Augmented visual feedback of movement performance to enhance walking recovery after stroke : study protocol for a pilot randomised controlled trial

Increasing evidence suggests that use of augmented visual feedback could be a useful approach to stroke rehabilitation. In current clinical practice, visual feedback of movement performance is often limited to the use of mirrors or video. However, neither approach is optimal since cognitive and self-image issues can distract or distress patients and their movement can be obscured by clothing or limited viewpoints. Three-dimensional motion capture has the potential to provide accurate kinematic data required for objective assessment and feedback in the clinical environment. However, such data are currently presented in numerical or graphical format, which is often impractical in a clinical setting. Our hypothesis is that presenting this kinematic data using bespoke visualisation software, which is tailored for gait rehabilitation after stroke, will provide a means whereby feedback of movement performance can be communicated in a more meaningful way to patients. This will result in increased patient understanding of their rehabilitation and will enable progress to be tracked in a more accessible way. The hypothesis will be assessed using an exploratory (phase II) randomised controlled trial. Stroke survivors eligible for this trial will be in the subacute stage of stroke and have impaired walking ability (Functional Ambulation Classification of 1 or more). Participants (n = 45) will be randomised into three groups to compare the use of the visualisation software during overground physical therapy gait training against an intensity-matched and attention-matched placebo group and a usual care control group. The primary outcome measure will be walking speed. Secondary measures will be Functional Ambulation Category, Timed Up and Go, Rivermead Visual Gait Assessment, Stroke Impact Scale-16 and spatiotemporal parameters associated with walking. Additional qualitative measures will be used to assess the participant's experience of the visual feedback provided in the study. Results from the trial will explore whether the early provision of visual feedback of biomechanical movement performance during gait rehabilitation demonstrates improved mobility outcomes after stroke and increased patient understanding of their rehabilitation

Cell Division and Motility Enable Hexatic Order in Biological Tissues

Biological tissues transform between solid-like and liquid-like states in many fundamental physiological events. Recent experimental observations further suggest that in two-dimensional epithelial tissues these solid-liquid transformations can happen via intermediate states akin to the intermediate hexatic phases observed in equilibrium two-dimensional melting. The hexatic phase is characterized by quasi-long-range (power-law) orientational order but no translational order, thus endowing some structure to an otherwise structureless fluid. While it has been shown that hexatic order in tissue models can be induced by motility and thermal fluctuations, the role of cell division and apoptosis (birth and death) has remained poorly understood, despite its fundamental biological role. Here we study the effect of cell division and apoptosis on global hexatic order within the framework of the self-propelled Voronoi model of tissue. Although cell division naively destroys order and active motility facilitates deformations, we show that their combined action drives a liquid-hexatic-liquid transformation as the motility increases. The hexatic phase is accessed by the delicate balance of dislocation defect generation from cell division and the active binding of disclination-antidisclination pairs from motility. We formulate a mean-field model to elucidate this competition between cell division and motility and the consequent development of hexatic order.Comment: 13 pages, 12 figures (6 in the main, 6 in the supplementary

Room Temperature Ferrimagnetism and Ferroelectricity in Strained, Thin Films of BiFe0.5Mn0.5O3.

Highly strained films of BiFe0.5Mn0.5O3 (BFMO) grown at very low rates by pulsed laser deposition were demonstrated to exhibit both ferrimagnetism and ferroelectricity at room temperature and above. Magnetisation measurements demonstrated ferrimagnetism (TC ∼ 600K), with a room temperature saturation moment (MS ) of up to 90 emu/cc (∼ 0.58 μB /f.u) on high quality (001) SrTiO3. X-ray magnetic circular dichroism showed that the ferrimagnetism arose from antiferromagnetically coupled Fe3+ and Mn3+. While scanning transmission electron microscope studies showed there was no long range ordering of Fe and Mn, the magnetic properties were found to be strongly dependent on the strain state in the films. The magnetism is explained to arise from one of three possible mechanisms with Bi polarization playing a key role. A signature of room temperature ferroelectricity in the films was measured by piezoresponse force microscopy and was confirmed using angular dark field scanning transmission electron microscopy. The demonstration of strain induced, high temperature multiferroism is a promising development for future spintronic and memory applications at room temperature and above.This is the final published version. It's also available from Advanced Functional Materials: http://onlinelibrary.wiley.com/doi/10.1002/adfm.201401464/full

Next-generation mitogenomics: A comparison of approaches applied to caecilian amphibian phylogeny

Mitochondrial genome (mitogenome) sequences are being generated with increasing speed due to the advances of next-generation sequencing (NGS) technology and associated analytical tools. However, detailed comparisons to explore the utility of alternative NGS approaches applied to the same taxa have not been undertaken. We compared a 'traditional' Sanger sequencing method with two NGS approaches (shotgun sequencing and non-indexed, multiplex amplicon sequencing) on four different sequencing platforms (Illumina's HiSeq and MiSeq, Roche's 454 GS FLX, and Life Technologies' Ion Torrent) to produce seven (near-) complete mitogenomes from six species that form a small radiation of caecilian amphibians from the Seychelles. The fastest, most accurate method of obtaining mitogenome sequences that we tested was direct sequencing of genomic DNA (shotgun sequencing) using the MiSeq platform. Bayesian inference and maximum likelihood analyses using seven different partitioning strategies were unable to resolve compellingly all phylogenetic relationships among the Seychelles caecilian species, indicating the need for additional data in this case