CLAVATA3 is a specific regulator of shoot and floral meristem development affecting the same processes as CLAVATA1

We have previously described the phenotype of Arabidopsis thaliana plants with mutations at the CLAVATA1 (CLV1) locus (Clark, S. E., Running, M. P. and Meyerowitz, E. M. (1993) Development 119, 397-418). Our investigations demonstrated that clv1 plants develop enlarged vegetative and inflorescence apical meristems, and enlarged and indeterminate floral meristems. Here, we present an analysis of mutations at a separate locus, CLAVATA3(CLV3), that disrupt meristem development in a manner similar to clv1mutations. clv3 plants develop enlarged apical meristems as early as the mature embryo stage. clv3 floral meristems are also enlarged compared with wild type, and maintain a proliferating meristem throughout flower development. clv3 root meristems are unaffected, indicating that CLV3 is a specific regulator of shoot and floral meristem development. We demonstrate that the strong clv3-2 mutant is largely epistatic to clv1 mutants, and that the semi-dominance of clv1 alleles is enhanced by double heterozygosity with clv3 alleles, suggesting that these genes work in the same pathway to control meristem development. We propose that CLV1 and CLV3 are required to promote the differentiation of cells at the shoot and floral meristem

Extending Foster Care to Age 21: Weighing the Costs to Government against the Benefits to Youth

The Fostering Connections to Success and Increasing Adoptions Act of 2008 allows states to claim federal reimbursement for the costs of caring for and supervising Title IV-E eligible foster youth until their 21st birthday. This issue brief provides preliminary estimates of what the potential costs to government and the benefits to young people would be if states extend foster care to age 21. The analysis focuses on the increase in postsecondary educational attainment associated with allowing foster youth to remain in care until they are 21 years old and the resulting increase in lifetime earnings associated with postsecondary education. Researchers estimate that lifetime earnings would increase an average of two dollars for every dollar spent on keeping foster youth in care beyond age 18

Mechanism of stimulated Hawking radiation in a laboratory Bose-Einstein condensate

We model a sonic black hole analog in a quasi one-dimensional Bose-Einstein condensate, using a Gross-Pitaevskii equation matching the configuration of a recent experiment by Steinhauer [Nat. Phys. 10, 864 (2014)]. The model agrees well with important features of the experimental observations, demonstrating their hydrodynamic nature. We find that a zero-frequency bow wave is generated at the inner (white hole) horizon, which grows in proportion to the square of the background condensate density. The relative motion of the black and white hole horizons produces a Doppler shift of the bow wave at the black hole, where it stimulates the emission of monochromatic Hawking radiation. The mechanism is confirmed using temporal and spatial windowed Fourier spectra of the condensate. Mean field behavior similar to that in the experiment can thus be fully explained without the presence of self-amplifying Hawking radiation.Comment: 24 pages; 19 figure

Geographic variability in Calligrapha verrucosa (Suffrian 1858), a willow-feeding leaf beetle from western North America(Coleoptera: Chrysomelidae)

A diagnosis is provided to separate Calligrapha verrucosa (Suffrian) from similar species. Geographic variability is described and illustrated for various populations of C. verrucosa. A map is provided to indicate the distribution of this species

A family affair: job loss and the mental health of spouses and adolescents

Examines the impact of involuntary job loss on the mental health of family members. Abstract This study examines the impact of involuntary job loss on the mental health of family members. Estimates from fixed-effects panel data models, using panel data for Australia, provide little evidence of any negative spillover effect on the mental health of husbands as a result of their wives\u27 job loss. The mental well-being of wives, however, declines following their husbands\u27 job loss, but only if that job loss results in a sustained period of non-employment or if the couple experienced financial hardship or relationship strain prior to the husband\u27s job loss. A negative effect of parental job loss on the mental health of co-resident adolescent children is also found, but appears to be restricted to girls

The role of grain dynamics in determining the onset of sediment transport

Sediment transport occurs when the nondimensional fluid shear stress $\Theta$ at the bed surface exceeds a minimum value $\Theta_c$. A large collection of data, known as the Shields curve, shows that $\Theta_c$ is primarily a function of the shear Reynolds number ${\rm{Re}}_*$. It is commonly assumed that $\Theta>\Theta_c({\rm{Re}}_*)$ occurs when the ${\rm Re}_*$-dependent fluid forces are too large to maintain static equilibrium for a typical surface grain. A complimentary approach, which remains relatively unexplored, is to identify $\Theta_c({\rm{Re}}_*)$ as the applied shear stress at which grains cannot stop moving. With respect to grain dynamics, ${\rm{Re}}_*$ can be viewed as the viscous time scale for a grain to equilibrate to the fluid flow divided by the typical time for the fluid force to accelerate a grain over the characteristic bed roughness. We performed simulations of granular beds sheared by a model fluid, varying only these two time scales. We find that the critical Shields number $\Theta_c({\rm Re}_*)$ obtained from the model mimics the Shields curve and is insensitive to the grain properties, the model fluid flow, and the form of the drag law. Quantitative discrepancies between the model results and the Shields curve are consistent with previous calculations of lift forces at varying ${\rm Re}_*$. Grains at low ${\rm Re}_*$ find more stable configurations than those at high ${\rm{Re}}_*$ due to differences in the grain reorganization dynamics. Thus, instead of focusing on mechanical equilibrium of a typical grain at the bed surface, $\Theta_c({\rm{Re}}_*)$ may be better described by the stress at which mobile grains cannot find a stable configuration and stop moving.Comment: to appear in Phys. Rev. Fluid

Heteroduplex analysis of tra delta f' plasmids and the mechanism of their formation

Four tra delta FargG+ plasmids, derived from matings between Hfr AB312 and a recA recipient, have been shown to have deletions of at least 50% of the F genome, including the region in which the tra genes map. The mutant plasmids do contain the F genes required for plasmid maintenance. Correlations can be made between, on the one hand, the F genes present on the tradelta F' plasmids and the F genes transferred early by an Hfr donor, and, on the other hand, the F genes deleted from the tradelta F' plasmids and the F genes transferred late by an Hfr donor. A biased representation of proximally and distally transferred chromosomal markers among the tradelta F' elements was also demonstrated. Taken Taken together, the asymmetrical representation of Hfr genes and the cis dominance of the Tra phenotype of these mutants can best be explained by the hypothesis that the tradelta F' plasmids are formed by repliconation of the transferred exogenote in a recA recipient

Happily entangled: prediction, emotion, and the embodied mind

Recent work in cognitive and computational neuroscience depicts the human cortex as a multi-level prediction engine. This ‘predictive processing’ framework shows great promise as a means of both understanding and integrating the core information processing strategies underlying perception, reasoning, and action. But how, if at all, do emotions and sub-cortical contributions fit into this emerging picture? The fit, we shall argue, is both profound and potentially transformative. In the picture we develop, online cognitive function cannot be assigned to either the cortical or the sub-cortical component, but instead emerges from their tight co-ordination. This tight co-ordination involves processes of continuous reciprocal causation that weave together bodily information and ‘top-down’ predictions, generating a unified sense of what’s out there and why it matters. The upshot is a more truly ‘embodied’ vision of the predictive brain in action