Re-structure : an exploration of relational engagement through objects & object making

Home is a loaded concept. For each of us it means a vast spectrum of associations, emotions and values. However, there are also a myriad of universal commonalities of what home is in our collective imaginations and experiences despite the increasingly transitory and elusive ideas about what home means for each of us. Whatever or wherever we might call home, our experiences within the walls of what we understand to be home impact and shape us. It is the physical and sociological structure that shapes our lives and the shelter from which we depart to grow into the larger world surrounding it. This body of work is an exploration of the construct of ‘home’ as both material and immaterial structure of relationships and objects. Through various approaches to projects across mediums and forms, I have sought to align my process of making with my own developing definition of home and of the domestic through means of connection, collaboration adn community. At the heart of these is a dependence and value of relationships. In exploring relational structures and objects that mediate them through the process of making, I have deepened my belief that relationships are at the core of who we are and how we choose to design our lives. With this in mind, my aim has been to investigate our relationship to objects, our relationship to the making of objects, and our relationship to others, their narratives and histories. Of the utmost import in driving these themes has been a desire to create objects that arise from personal and meaningful places that go further to become structures of support for the life and development of new narratives

A Leishmania major Response Locus Identified by Interval-specific Congenic Mapping of a T Helper Type 2 Cell Bias-controlling Quantitative Trait Locus

The propensity of naive CD4 T cells to become T helper (Th) type 2 cells correlates with susceptibility to infection by the protozoal parasite Leishmania major. Using genetic linkage analysis, we earlier identified Dice1 as a Th2 cell bias-controlling quantitative trait locus on chromosome 16. Using interval-specific congenic mapping, we now resolve Dice1 into two independent genetic loci, Dice1.1 and Dice1.2, which control Il4 expression from naive Th cells and thereby indirectly control Th2 cell bias. Interestingly, only one of the two congenic intervals containing Dice1.1 and Dice1.2, respectively, also contained an L. major response locus, indicating that L. major responsiveness can be insensitive to determinants that influence Th2 cell bias by controlling naive T cell Il4 expression. These results lay the groundwork for identifying the Dice1.1 and Dice1.2 genes controlling naive T cell Il4 expression and L. major responses, and for testing whether these control other Th2 cell–dependent processes such as worm expulsion, allergic asthma, and dermatitis

Bidirectional pressure: a mini review of ventilator-lung-kidney interactions

Acute kidney injury and respiratory failure that requires mechanical ventilation are both common complications of critical illnesses. Failure of either of these organ systems also increases the risk of failure to the other. As a result, there is a high incidence of patients with concomitant acute kidney injury and the need for mechanical ventilation, which has a devasting impact on intensive care unit outcomes, including mortality. Despite decades of research into the mechanisms of ventilator-lung-kidney interactions, several gaps in knowledge remain and current treatment strategies are primarily supportive. In this review, we outline our current understanding of the mechanisms of acute kidney injury due to mechanical ventilation including a discussion of; 1) The impact of mechanical ventilation on renal perfusion, 2) activation of neurohormonal pathways by positive pressure ventilation, and 3) the role of inflammatory mediators released during ventilator induced lung injury. We also provide a review of the mechanisms by which acute kidney injury increases the risk of respiratory failure. Next, we outline a summary of the current therapeutic approach to preventing lung and kidney injury in the critically ill, including fluid and vasopressor management, ventilator strategies, and treatment of acute kidney injury. Finally, we conclude with a discussion outlining opportunities for novel investigations that may provide a rationale for new treatment approaches

The Grizzly, January 24, 1995

Ursinus College and the U.S. News and World Report Rating System • Ursinus Concludes The Next Step Campaign • 4,000 Casualties in Japanese Earthquake • Newt Confronts Ethics Issues • Local Bank Robber Brought Up on Federal Charges • Politics Department Update • Servant-Leadership Program Comes to Ursinus • St. Andrew\u27s Society of Philadelphia Scholarships • An Afternoon with Picasso and Moore • Thirdgill Kicks Off This Semester\u27s Comedy • Star Trek: Voyager Launches • Support Your Coffee House • Not-So-Super Super Bowl • Alumnus Expresses Concern Over Oversight • Men\u27s B-Ball Snaps Two-Game Skid • Bears Ready For Conference Showdown with Muhlenberg • Gymnasts Off to a Raging Start • Bears Win Triangular Meet • Aqua Bears Swept by Gettysburg • Lady Bears are Ranked For the First Timehttps://digitalcommons.ursinus.edu/grizzlynews/1350/thumbnail.jp

The Grizzly, February 14, 1995

New York City Terrorist Mastermind Pleads Guilty • Advertising, Capitalism, and Mars Bars • Bogota Quake Kills 29 • Study Abroad Offers Opportunity of a Lifetime • Student Spotlight: Laura Lecrone • Alumnae Spotlight: John Zerr • Separate Ghettos in Mall of America • Multiculturalism: Not Just for Minorities • Gymnasts Break Record Again • Men\u27s Hoop Team Loses Two More Heartbreakers • Wrestlers Tune up for Conference Championship • Women\u27s Hoop Team Stumbles Againhttps://digitalcommons.ursinus.edu/grizzlynews/1353/thumbnail.jp

The Grizzly, April 11, 1995

ProTheatre Stages Our Country\u27s Good • Congratulations to the New Phi Beta Kappa Members • Letter to the Editor: Where Have All Our Leaders Gone?; Gay Rights at Ursinus • Quiet Please! • Hello, This is the Phone Mail System • Why Examine Curriculum? • Student Exhibition to Open April 25 • Course Preview: Women in Politics • Final Exam Schedule • Environmental Club Activities Planned to Commemorate Earth Day • Alumnae Spotlight: Kim Caffey • Baseball Team Earns Big Win Over Hopkins • Men\u27s Tennis Gets First Win • Golfers Placed Second at Gettysburg • Women\u27s Tennis Looking for First Win • Trecroce Keys Ursinus Sweep as Softball Team Stays in the Race • Kiwak Named Player of the Week • Landis Named Player of the Week • Cosgrove Honored • Lacrosse Unbeaten in Conference Playhttps://digitalcommons.ursinus.edu/grizzlynews/1359/thumbnail.jp

The Grizzly, February 1, 1994

Ursinus Begins Celebration of 125th Anniversary • Group Formed to Study Pledging • Stevens Speaks Against Hazing • Ursinus Mourns Loss of Professor • Clinton Delivers State of the Union • Airband is Coming! • Rodent Mutiny and Other Ursinus Hazards • Lost in a Computer World • Ursinus Open, Weather or Not • The Exchange Continues • A Year of Milestones • Muleya Named Head Soccer Coachhttps://digitalcommons.ursinus.edu/grizzlynews/1328/thumbnail.jp

The Grizzly, February 23, 1993

Helen Thomas, White House Correspondent Speaks • Pledging: Girls\u27 Results From Fall 1992 Versus Outward Bound, 1993 • Clinton\u27s Plans for Peace • Airband, MTV Here • Evaluating the Curriculum of Ursinus • Ursinus Welcomes Ishmael Reed • Movie Review: Sommersby • South Street: An Informative Perspective • Senior Profile: Casey Price • Who\u27s in Charge at 1600? • Letter to the Editor • Gymnasts Achieve Season-High • Two Ursinus Legends Step Down • Thomas adds Sports Manager Duties • Swimmers Done • Bears Finish 7-17; Look to Bright Futurehttps://digitalcommons.ursinus.edu/grizzlynews/1310/thumbnail.jp

The Grizzly, March 23, 1993

Ursinus Mourns The Loss of One of Our Own • Worst Storm of the Century • Danceteller Performs at Ursinus • Ursinus\u27s Own Ticketron • Consider Women\u27s Studies • Wismer Rolls Out the Red Carpet • College Needs Policy on Closing • No Class • The Right to Life • U.C. Baseball Heading in Right Direction • Softball Breaks Even in the Carolinas • Three Outstanding Jens • Gymnasts at Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1312/thumbnail.jp

The Grizzly, March 1, 1994

Up \u27Til Noone to Play at The Trappe • Last Semester\u27s Blood Drive a Success • Kane Encourages Support for Blood Drive • CIA Officer and his Wife Accused of Spying • Professor Profile: Keith Brand • Broughton Exhibit to Open in Berman • Senior Profile: Alan McCabe • The Snow Closing Debates, Continued • Letter to the Editor • To All Administrators, Faculty, Staff, and Other Interested Parties • Women\u27s Hoops Have Best Season Everhttps://digitalcommons.ursinus.edu/grizzlynews/1332/thumbnail.jp