What is the most effective treatment for tinea pedis (athlete's foot)?

Topical therapy is effective for tinea pedis. Topical terbinafine has a 70% cure rate, is available over the counter (OTC), and requires only 1 to 2 weeks of therapy. Two other OTC topicals, tolnaftate and miconazole, require 2 to 4 weeks to achieve slightly lower cure rates, but are considerably less expensive. (Grade of recommendation: A) The most effective treatment for tinea pedis is oral terbinafine 250 mg twice a day for 2 weeks (94% clinical cure rate). However, oral terbinafine is expensive and not approved for this indication. Oral therapy may be required for patients with hyperkerototic soles, severe disease, topical therapy failure, chronic infection or immunosuppression. (Grade of recommendation: B, based on small randomized controlled trials [RCTs] with limited head-to head comparisons of drugs

X-ray spectral diagnostics of activity in massive stars

X-rays give direct evidence of instabilities, time-variable structure, and shock heating in the winds of O stars. The observed broad X-ray emission lines provide information about the kinematics of shock-heated wind plasma, enabling us to test wind-shock models. And their shapes provide information about wind absorption, and thus about the wind mass-loss rates. Mass-loss rates determined from X-ray line profiles are not sensitive to density-squared clumping effects, and indicate mass-loss rate reductions of factors of 3 to 6 over traditional diagnostics that suffer from density-squared effects. Broad-band X-ray spectral energy distributions also provide mass-loss rate information via soft X-ray absorption signatures. In some cases, the degree of wind absorption is so high that the hardening of the X-ray SED can be quite significant. We discuss these results as applied to the early O stars zeta Pup (O4 If), 9 Sgr (O4 V((f))), and HD 93129A (O2 If*).Comment: To appear in the proceedings of IAU 272: Active OB Star

The VLT-FLAMES Tarantula Survey. VII. A low velocity dispersion for the young massive cluster R136

Detailed studies of resolved young massive star clusters are necessary to determine their dynamical state and evaluate the importance of gas expulsion and early cluster evolution. In an effort to gain insight into the dynamical state of the young massive cluster R136 and obtain the first measurement of its velocity dispersion, we analyse multi-epoch spectroscopic data of the inner regions of 30 Doradus in the Large Magellanic Cloud (LMC) obtained as part of the VLT-FLAMES Tarantula Survey. Following a quantitative assessment of the variability, we use the radial velocities of non-variable sources to place an upper limit of 6 km/s on the line-of-sight velocity dispersion of stars within a projected distance of 5 pc from the centre of the cluster. After accounting for the contributions of undetected binaries and measurement errors through Monte Carlo simulations, we conclude that the true velocity dispersion is likely between 4 and 5 km/s given a range of standard assumptions about the binary distribution. This result is consistent with what is expected if the cluster is in virial equilibrium, suggesting that gas expulsion has not altered its dynamics. We find that the velocity dispersion would be ~25 km/s if binaries were not identified and rejected, confirming the importance of the multi-epoch strategy and the risk of interpreting velocity dispersion measurements of unresolved extragalactic young massive clusters.Comment: 18 pages, 7 figures, accepted by A&

Rotational properties of the O-type star population in the Tarantula region

The 30 Doradus (30\,Dor) region in the Large Magellanic Cloud (also known as the Tarantula Nebula) is the nearest massive starburst region, containing the richest sample of massive stars in the Local Group. It is the best possible laboratory to investigate aspects of the formation and evolution of massive stars. Here, we focus on rotation which is a key parameter in the evolution of these objects. We establish the projected rotational velocity, $v_{e}\sin i$, distribution of an unprecedented sample of 216 radial velocity constant ($\rm{\Delta RV\, \leq\, 20 \,km s^{-1}}$) O-type stars in 30\,Dor observed in the framework of the VLT-FLAMES Tarantula Survey (VFTS). The distribution of $v_{e}\sin i$ shows a two-component structure: a peak around 80 $\rm{km s^{-1}}$ and a high-velocity tail extending up to $\sim$600 $\rm{km s^{-1}}$. Around 75% of the sample has 0 $\leq\, v_{e}\sin i \leq$ 200 $\rm{km s^{-1}}$ with the other 25% distributed in the high-velocity tail. The presence of the low-velocity peak is consistent with that found in other studies of late-O and early-B stars. The high-velocity tail is compatible with expectations from binary interaction synthesis models and may be predominantly populated by post-binary interaction, spun-up, objects and mergers. This may have important implications for the nature of progenitors of long-duration gamma ray bursts.Comment: 4 pages, 1 figure. Conference proceedings article: Massive stars: from alpha to Omega, 10-14 June 2013, Rhodes, Greec

The VLT-FLAMES Tarantula Survey XVIII. Classifications and radial velocities of the B-type stars

We present spectral classifications for 438 B-type stars observed as part of the VLT-FLAMES Tarantula Survey (VFTS) in the 30 Doradus region of the Large Magellanic Cloud. Radial velocities are provided for 307 apparently single stars, and for 99 targets with radial-velocity variations which are consistent with them being spectroscopic binaries. We investigate the spatial distribution of the radial velocities across the 30 Dor region, and use the results to identify candidate runaway stars. Excluding potential runaways and members of two older clusters in the survey region (SL 639 and Hodge 301), we determine a systemic velocity for 30 Dor of 271.6 ± 12.2 kms-1 from 273 presumed single stars. Employing a 3σ criterion we identify nine candidate runaway stars (2.9% of the single stars with radial-velocity estimates). The projected rotational velocities of the candidate runaways appear to be significantly different to those of the full B-type sample, with a strong preference for either large (≥345 kms-1) or small (≤65 kms-1) rotational velocities. Of the candidate runaways, VFTS 358 (classified B0.5: V) has the largest differential radial velocity (−106.9 ± 16.2 kms-1), and a preliminary atmospheric analysis finds a significantly enriched nitrogen abundance of 12 + log (N/H) ≳ 8.5. Combined with a large rotational velocity (ve sin i = 345 ± 22 kms-1), this is suggestive of past binary interaction for this star

Social representations of HIV/AIDS in five Central European and Eastern European countries: A multidimensional analysis

Cognitive processing models of risky sexual behaviour have proliferated in the two decades since the first reporting of HIV/AIDS, but far less attention has been paid to individual and group representations of the epidemic and the relationship between these representations and reported sexual behaviours. In this study, 494 business people and medics from Estonia, Georgia, Hungary, Poland and Russia sorted free associations around HIV/AIDS in a matrix completion task. Exploratory factor and multidimensional scaling analyses revealed two main dimensions (labelled ‘Sex’ and ‘Deadly disease’), with significant cultural and gender variations along both dimension scores. Possible explanations for these results are discussed in the light of growing concerns over the spread of the epidemic in this region

The VLT-FLAMES Tarantula Survey XIX. B-type Supergiants - Atmospheric parameters and nitrogen abundances to investigate the role of binarity and the width of the main sequence

TLUSTY non-LTE model atmosphere calculations have been used to determine atmospheric parameters and nitrogen (N) abundances for 34 single and 18 binary B-type supergiants (BSGs). The effects of flux contribution from an unseen secondary were considered for the binary sample. We present the first systematic study of the incidence of binarity for a sample of BSGs across the theoretical terminal age main sequence (TAMS). To account for the distribution of effective temperatures of the BSGs it may be necessary to extend the TAMS to lower temperatures. This is consistent with the derived distribution of mass discrepancies, projected rotational velocities (vsini) and N abundances, provided that stars cooler than this temperature are post RSG objects. For the BSGs in the Tarantula and previous FLAMES surveys, most have small vsini. About 10% have larger vsini (>100 km/s) but surprisingly these show little or no N enhancement. All the cooler BSGs have low vsini of <70km/s and high N abundance estimates, implying that either bi-stability braking or evolution on a blue loop may be important. A lack of cool binaries, possibly reflects the small sample size. Single star evolutionary models, which include rotation, can account for the N enhancement in both the single and binary samples. The detailed distribution of N abundances in the single and binary samples may be different, possibly reflecting differences in their evolutionary history. The first comparative study of single and binary BSGs has revealed that the main sequence may be significantly wider than previously assumed, extending to Teff=20000K. Some marginal differences in single and binary atmospheric parameters and abundances have been identified, possibly implying non-standard evolution for some of the sample. This sample as a whole has implications for several aspects of our understanding of the evolution of BSGs. Full abstract in paperComment: 21 pages, 15 figures, 11 table

Rotational velocities of single and binary O-type stars in the Tarantula Nebula

Rotation is a key parameter in the evolution of massive stars, affecting their evolution, chemical yields, ionizing photon budget, and final fate. We determined the projected rotational velocity, $v_e\sin i$, of $\sim$330 O-type objects, i.e. $\sim$210 spectroscopic single stars and $\sim$110 primaries in binary systems, in the Tarantula nebula or 30 Doradus (30\,Dor) region. The observations were taken using VLT/FLAMES and constitute the largest homogeneous dataset of multi-epoch spectroscopy of O-type stars currently available. The most distinctive feature of the $v_e\sin i$ distributions of the presumed-single stars and primaries in 30 Dor is a low-velocity peak at around 100\,$\rm{km s^{-1}}$. Stellar winds are not expected to have spun-down the bulk of the stars significantly since their arrival on the main sequence and therefore the peak in the single star sample is likely to represent the outcome of the formation process. Whereas the spin distribution of presumed-single stars shows a well developed tail of stars rotating more rapidly than 300\,$\rm{km s^{-1}}$, the sample of primaries does not feature such a high-velocity tail. The tail of the presumed-single star distribution is attributed for the most part -- and could potentially be completely due -- to spun-up binary products that appear as single stars or that have merged. This would be consistent with the lack of such post-interaction products in the binary sample, that is expected to be dominated by pre-interaction systems. The peak in this distribution is broader and is shifted toward somewhat higher spin rates compared to the distribution of presumed-single stars. Systems displaying large radial velocity variations, typical for short period systems, appear mostly responsible for these differences.Comment: 6 pages, 3 figures, Proceedings IAU Symposium No. 307, 2014, 'New windows on massive stars: asteroseismology, interferometry, and spectropolarimetry

Migrants with insecure legal status and access to work: the role of ethnic solidarity networks

This article explores the complexities of ethnic solidarity and ethnic capital in enabling participation on labour markets for migrants with insecure legal status in the UK. By drawing together research insights and data from a questionnaire survey of 178 Iraqi-Kurdish migrants with insecure legal status, four focus groups and ten expert interviews, this paper examines how ‘unauthorised’ migrants get access to the segmented labour market at a time of increased in-border controls in the UK. It argues that conflict-generated diasporas such as the Kurds display a distinct solidarity with their community members with insecure legal status and provide access to the labour markets against the tangible threat of in-border migration enforcement. We term this form of solidarity as stretched solidarity which emerges during risky, difficult and destitute times and it is a reluctant act of empathy and socio-political position. This paper identifies the social phenomenon of stretched solidarity and sets out a model for understanding its embeddedness within conflict-generated diasporic networks