Mapping Vesta: First Results from Dawn’s Survey Orbit

The geologic objectives of the Dawn Mission [1] are to derive Vesta’s shape, map the surface geology, understand the geological context and contribute to the determination of the asteroids’ origin and evolution.Geomorphology and distribution of surface features will provide evidence for impact cratering, tectonic activity, volcanism, and regolith processes. Spectral measurements of the surface will provide evidence of the compositional characteristics of geological units. Age information, as derived from crater sizefrequency distributions, provides the stratigraphic context for the structural and compositional mapping results, thus revealing the geologic history of Vesta. We present here the first results of the Dawn mission from data collected during the approach to Vesta, and its first discrete orbit phase – the Survey Orbit, which lasts 21 days after the spacecraft had established a circular polar orbit at a radius of ~3000 km with a beta angle of 10°-15°

Clear cell sarcoma-A review

Clear cell sarcoma (CCS) previously known as malignant melanoma (MM) of the soft tissue, although, similar in morphology to MM, contemporary histopathologic and cytogenetic techniques have made this diagnosis obsolete, as it is now possible to distinguish between CCS and MM. CCS is often diagnosed in young adults with median age of 25 years. Overall mortality is generally poor, and the 5-year survival is between 40 and 60%. Hence, early diagnosis and radical surgery are key in the treatment of this extremely rare malignancy of the soft tissue comprising only about 1% of all sarcomas. This article present an overview of this rare malignancy.</p

VVUQ of a thermal-hydraulic multi-scale tool on unprotected loss of flow accident in SFR reactor

Within the framework of the French 4th-generation Sodium-cooled Fast Reactor safety assessment, methodology on VVUQ (Verification, Validation, Uncertainty Quantification) is conducted to demonstrate that the CEA's thermal-hydraulic Scientific Computation Tools (SCTs) are effective and operational for design and safety studies purposes on this type of reactor. This VVUQ-based qualification is a regulatory requirement from the French Nuclear Safety Authority (NSA). In this paper, the current practice of VVUQ approach application for a SFR accidental transient is described with regard to the NSA requirements. It constitutes the first practical, progressively improvable approach. As the SCT is qualified for a given version on a given scenario, the transient related to a total unprotected station blackout has been selected. As it is a very complex multi-scale transient, the SCT MATHYS (which is a coupling of the CATHARE2 tool at system scale, TrioMC tool at component scale and TrioCFD tool at local scale) is used. This paper presents the preliminary VVUQ application to the qualification of this tool on this selected transient. In addition, this work underlines some feedback on design and R&D aspects that should be addressed in the future to improve the SCT

Initiation of the Primate Genome Project

This work was supported by the National Natural Science Foundation of China (31822048) and Strategic Priority Research Program of the Chinese Academy of Sciences (XDPB17

VVUQ of a thermal-hydraulic multi-scale tool on unprotected loss of flow accident in SFR reactor

Within the framework of the French 4th-generation Sodium-cooled Fast Reactor safety assessment, methodology on VVUQ (Verification, Validation, Uncertainty Quantification) is conducted to demonstrate that the CEA's thermal-hydraulic Scientific Computation Tools (SCTs) are effective and operational for design and safety studies purposes on this type of reactor. This VVUQ-based qualification is a regulatory requirement from the French Nuclear Safety Authority (NSA). In this paper, the current practice of VVUQ approach application for a SFR accidental transient is described with regard to the NSA requirements. It constitutes the first practical, progressively improvable approach. As the SCT is qualified for a given version on a given scenario, the transient related to a total unprotected station blackout has been selected. As it is a very complex multi-scale transient, the SCT MATHYS (which is a coupling of the CATHARE2 tool at system scale, TrioMC tool at component scale and TrioCFD tool at local scale) is used. This paper presents the preliminary VVUQ application to the qualification of this tool on this selected transient. In addition, this work underlines some feedback on design and R&amp;D aspects that should be addressed in the future to improve the SCT.</jats:p

Transcriptome innovations in primates revealed by single-molecule long-read sequencing

Transcriptomic diversity greatly contributes to the fundamentals of disease, lineage-specific biology, and environmental adaptation. However, much of the actual isoform repertoire contributing to shaping primate evolution remains unknown. Here, we combined deep long- and short-read sequencing complemented with mass spectrometry proteomics in a panel of lymphoblastoid cell lines (LCLs) from human, three other great apes, and rhesus macaque, producing the largest full-length isoform catalog in primates to date. Around half of the captured isoforms are not annotated in their reference genomes, significantly expanding the gene models in primates. Furthermore, our comparative analyses unveil hundreds of transcriptomic innovations and isoform usage changes related to immune function and immunological disorders. The confluence of these evolutionary innovations with signals of positive selection and their limited impact in the proteome points to changes in alternative splicing in genes involved in immune response as an important target of recent regulatory divergence in primates.</jats:p