Milk whey protein concentration and mRNA associated with β-lactoglobulin phenotype

Two common genetic variants of β-lactoglobulin (β-lg), A and B, exist as co- dominant alleles in dairy cattle (Aschaffenburg, 1968). Numerous studies have shown that cows homozygous for β-lg A have more β-lg and less α-lactalbumin (α-la) and casein in their milk than cows expressing only the B variant of β-lg (Ng-Kwai-Hang et al. 1987; Graml et al. 1989; Hill, 1993; Hill et al. 1995, 1997). These differences have a significant impact on the processing characteristics of the milk. For instance, the moisture-adjusted yield of Cheddar cheese is up to 10% higher using milk from cows of the β-lg BB phenotype compared with milk from cows expressing only the A variant (Hill et al. 1997). All these studies, however, describe compositional differences associated with β-lg phenotype in established lactation only. No information is available on the first few weeks of lactation, when there are marked changes in the concentrations of β-lg and α-la (Pérez et al. 1990)

Targeted interventions for patellofemoral pain syndrome (TIPPS): classification of clinical subgroups

Introduction Patellofemoral pain (PFP) can cause significant pain leading to limitations in societal participation and physical activity. An international expert group has highlighted the need for a classification system to allow targeted intervention for patients with PFP; we have developed a work programme systematically investigating this. We have proposed six potential subgroups: hip abductor weakness, quadriceps weakness, patellar hypermobility, patellar hypomobility, pronated foot posture and lower limb biarticular muscle tightness. We could not uncover any evidence of the relative frequency with which patients with PFP fell into these subgroups or whether these subgroups were mutually exclusive. The aim of this study is to provide information on the clinical utility of our classification system. Methods and analysis 150 participants will be recruited over 18 months in four National Health Services (NHS) physiotherapy departments in England. Inclusion criteria: adults 18–40 years with PFP for longer than 3 months, PFP in at least two predesignated functional activities and PFP elicited by clinical examination. Exclusion criteria: prior or forthcoming lower limb surgery; comorbid illness or health condition; and lower limb training or pregnancy. We will record medical history, demographic details, pain, quality of life, psychomotor movement awareness and knee temperature. We will assess hip abductor and quadriceps weakness, patellar hypermobility and hypomobility, foot posture and lower limb biarticular muscle tightness. The primary analytic approach will be descriptive. We shall present numbers and percentages of participants who meet the criteria for membership of (1) each of the subgroups, (2) none of the subgroups and (3) multiple subgroups. Exact (binomial) 95% CIs for these percentages will also be presented. Ethics and dissemination This study has been approved by National Research Ethics Service (NRES) Committee North West—Greater Manchester North (11/NW/0814) and University of Central Lancashire (UCLan) Built, Sport, Health (BuSH) Ethics Committee (BuSH 025). An abstract has been accepted for the third International Patellofemoral Pain Research Retreat, Vancouver, September 2013

Inflationary Cosmological Perturbations of Quantum-Mechanical Origin

This review article aims at presenting the theory of inflation. We first describe the background spacetime behavior during the slow-roll phase and analyze how inflation ends and the Universe reheats. Then, we present the theory of cosmological perturbations with special emphasis on their behavior during inflation. In particular, we discuss the quantum-mechanical nature of the fluctuations and show how the uncertainty principle fixes the amplitude of the perturbations. In a next step, we calculate the inflationary power spectra in the slow-roll approximation and compare these theoretical predictions to the recent high accuracy measurements of the Cosmic Microwave Background radiation (CMBR) anisotropy. We show how these data already constrain the underlying inflationary high energy physics. Finally, we conclude with some speculations about the trans-Planckian problem, arguing that this issue could allow us to open a window on physical phenomena which have never been probed so far.Comment: Review Article, 47 pages, 3 figures. Lectures given at the 40th Karpacz Winter School on Theoretical Physics (Poland, Feb. 2004), submitted to Lecture Notes in Physic

Dependence of Inflationary Reconstruction upon Cosmological Parameters

The inflationary potential and its derivatives determine the spectrum of scalar and tensor metric perturbations that arise from quantum fluctuations during inflation. The CBR anisotropy offers a promising means of determining the spectra of metric perturbations and thereby a means of constraining the inflationary potential. The relation between the metric perturbations and CBR anisotropy depends upon cosmological parameters -- most notably the possibility of a cosmological constant. Motivated by some observational evidence for a cosmological constant (large-scale structure, cluster-baryon fraction, measurements of the Hubble constant and age of the Universe) we derive the reconstruction equations and consistency relation to second order in the presence of a cosmological constant. We also clarify previous notation and discuss alternative schemes for reconstruction.Comment: 15 pages, LaTeX, 3 postscript figures (included with epsf), submitted to Phys. Rev.

NASA Light Emitting Diode Medical Applications from Deep Space to Deep Sea

This work is supported and managed through the NASA Marshall Space Flight Center-SBIR Program. LED-technology developed for NASA plant growth experiments in space shows promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. We present the results of LED-treatment of cells grown in culture and the effects of LEDs on patients’ chronic and acute wounds. LED-technology is also biologically optimal for photodynamic therapy of cancer and we discuss our successes using LEDs in conjunction with light-activated chemotherapeutic drugs

An extragalactic supernebula confined by gravity

Little is known about the origins of the giant star clusters known as globular clusters. How can hundreds of thousands of stars form simultaneously in a volume only a few light years across the distance of the sun to its nearest neighbor? Radiation pressure and winds from luminous young stars should disperse the star-forming gas and disrupt the formation of the cluster. Globular clusters in our Galaxy cannot provide answers; they are billions of years old. Here we report the measurement of infrared hydrogen recombination lines from a young, forming super star cluster in the dwarf galaxy, NGC 5253. The lines arise in gas heated by a cluster of an estimated million stars, so young that it is still enshrouded in gas and dust, hidden from optical view. We verify that the cluster contains 4000-6000 massive, hot "O" stars. Our discovery that the gases within the cluster are bound by gravity may explain why these windy and luminous O stars have not yet blown away the gases to allow the cluster to emerge from its birth cocoon. Young clusters in "starbursting" galaxies in the local and distant universe may be similarly gravitationally confined and cloaked from view.Comment: Letter to Natur

Gravitational Waves from Collapsing Vacuum Domains

The breaking of an approximate discrete symmetry, the final stages of a first order phase transition, or a post-inflationary biased probability distribution for scalar fields are possible cosmological scenarios characterized by the presence of unstable domain wall networks. Combining analytical and numerical techniques, we show that the non-spherical collapse of these domains can be a powerful source of gravitational waves. We compute their contribution to the stochastic background of gravitational radiation and explore their observability by present and future gravitational wave detectors.Comment: Revised version to appear in Physical Review Letters. Changes have been made which improve the presentation of the results. Figure 3 was modified, but conclusions remain the sam

Theta angle versus CP violation in the leptonic sector

Assuming that the axion mechanism of solving the strong CP problem does not exist and the vanishing of theta at tree level is achieved by some model-building means, we study the naturalness of having large CP-violating sources in the leptonic sector. We consider the radiative mechanisms which transfer a possibly large CP-violating phase in the leptonic sector to the theta parameter. It is found that large theta cannot be induced in the models with one Higgs doublet as at least three loops are required in this case. In the models with two or more Higgs doublets the dominant source of theta is the phases in the scalar potential, induced by CP violation in leptonic sector. Thus, in the MSSM framework the imaginary part of the trilinear soft-breaking parameter A_l generates the corrections to the theta angle already at one loop. These corrections are large, excluding the possibility of large phases, unless the universality in the slepton sector is strongly violated.Comment: 5 pages, 2 figure

Imprints of Short Distance Physics On Inflationary Cosmology

We analyze the impact of certain modifications to short distance physics on the inflationary perturbation spectrum. For the specific case of power-law inflation, we find distinctive -- and possibly observable -- effects on the spectrum of density perturbations.Comment: Revtex 4, 3 eps figs, 4 page

Observationally Determining the Properties of Dark Matter

Determining the properties of the dark components of the universe remains one of the outstanding challenges in cosmology. We explore how upcoming CMB anisotropy measurements, galaxy power spectrum data, and supernova (SN) distance measurements can observationally constrain their gravitational properties with minimal assumptions on the theoretical side. SN observations currently suggest the existence of dark matter with an exotic equation of state p/rho < -1/3 that accelerates the expansion of the universe. When combined with CMB anisotropy measurements, SN or galaxy survey data can in principle determine the equation of state and density of this component separately, regardless of their value, as long as the universe is spatially flat. Combining these pairs creates a sharp consistency check. If p/rho > -1/2, then the clustering behavior (sound speed) of the dark component can be determined so as to test the scalar-field ``quintessence'' hypothesis. If the exotic matter turns out instead to be simply a cosmological constant (p/rho = -1), the combination of CMB and galaxy survey data should provide a significant detection of the remaining dark matter, the neutrino background radiation (NBR). The gross effect of its density or temperature on the expansion rate is ill-constrained as it is can be mimicked by a change in the matter density. However, anisotropies of the NBR break this degeneracy and should be detectable by upcoming experiments.Comment: 16 pages, 10 figures, RevTeX, submitted to PR