Do drinking motives mediate the relationship between neighborhood characteristics and alcohol use among adolescents?

Funding: Funding for the Scottish Health Behaviour in School-aged Children was provided by NHS Scotland. This work was also supported by the 600th Anniversary Ph.D. Scholarship which was awarded to Gina Martin by the University of St Andrews.Adolescents not only vary in their alcohol use behavior but also in their motivations for drinking. Young people living in different neighborhoods may drink for different reasons. The aims of this study were to determine if neighborhood characteristics were associated with adolescent drinking motives, and whether drinking motives mediate the relationship between neighborhood context and regular alcohol use. Data from the Scottish Health Behaviours in School-aged Children 2010 survey of students in their 4th year of secondary school were used. The study included 1119 participants who had data on neighborhood characteristics and had used alcohol in the past year. Students were asked questions about the local area where they lived, their alcohol use, and their motives for drinking alcohol, based on the Drinking Motives Questionnaire Revised Short Form (DMQR-SF). Multilevel multivariable models and structural equation models were used in this study. Coping motives showed significant variation across neighborhoods. Structural equation models showed coping motives mediated the relationships between neighborhood deprivation, living in an accessible small-town, and neighborhood-level disorder with regular alcohol use. Public health policies that improve neighborhood conditions and develop adaptive strategies, aimed at improving alcohol-free methods for young people to cope better with life’s stresses, may be particularly effective in reducing inequalities in adolescent alcohol use if targeted at small towns and areas of increased deprivation.Publisher PDFPeer reviewe

Agroecological condition of land in tomsk region and prospects of application of methods of remote sensing

On base of studying the satellite images data received and processed at the space monitoring Center, Tomsk state University of control systems and Radioelectronics, and the results of ground agroenvironmental monitoring of arable land in Tomsk region performed by Federal state budgetary institution "Agrochemical service Station "Tomsk", revealed 39% of unused arable land, overgrown forest. From these investigations was find that the land used in agricultural production according to agro-chemical service, a decrease in soil fertility: decrease in organic matter content from 5 to 21%, increase in the proportion of acidic soils by 10 - 30%. The analysis of the main causes of negative trends in land use in Tomsk region was performed. The organizational and agro technical measures that increase the efficiency of use of arable land were developed. At the present stage is also required adaptation in the monitoring of agricultural land methods of Earth remote sensing, taking into account local soil and vegetation, and climatic conditions. There is a problem of integration of data with local ground measurements (and aircrafts) in order to bring them to a common spatial and temporal grid of satellite measurements, to construct dynamic models of seasonal cycles used to evaluate the observed changes of satellite data

Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Background: Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. Diseased lungs are of specific interest, since these are the main recipients of inhalation therapy. We, therefore, used Scnn1b-transgenic (Tg) mice as a model of chronic obstructive pulmonary disease (COPD) and compared uptake and localization of inhaled AuNP in surface macrophages and lung tissue to wild-type (Wt) mice. Methods: Scnn1b-Tg and Wt mice inhaled a 21-nm AuNP aerosol for 2 h. Immediately (0 h) or 24 h thereafter, bronchoalveolar lavage (BAL) macrophages and whole lungs were prepared for stereological analysis of AuNP by electron microscopy. Results: AuNP were mainly found as singlets or small agglomerates of ≤ 100 nm diameter, at the epithelial surface and within lung-surface structures. Macrophages contained also large AuNP agglomerates (> 100 nm). At 0 h after aerosol inhalation, 69.2±4.9% AuNP were luminal, i.e. attached to the epithelial surface and 24.0±5.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 35.3±32.2% AuNP were on the epithelium and 58.3±41.4% in macrophages. The percentage of luminal AuNP decreased from 0 h to 24 h in both groups. At 24 h, 15.5±4.8% AuNP were luminal, 21.4±14.2% within epithelial cells and 63.0±18.9% in macrophages in Scnn1b-Tg mice. In Wt mice, 9.5±5.0% AuNP were luminal, 2.2±1.6% within epithelial cells and 82.8±0.2% in macrophages. BAL-macrophage analysis revealed enhanced AuNP uptake in Wt animals at 0 h and in Scnn1b-Tg mice at 24 h, confirming less efficient macrophage uptake and delayed clearance of AuNP in Scnn1b-Tg mice. Conclusions: Inhaled AuNP rapidly bound to the alveolar epithelium in both Wt and Scnn1b-Tg mice. Scnn1b-Tg mice showed less efficient AuNP uptake by surface macrophages and concomitant higher particle internalization by alveolar type I epithelial cells compared to Wt mice. This likely promotes AuNP depth translocation in Scnn1b-Tg mice, including enhanced epithelial targeting. These results suggest AuNP nanocarrier delivery as successful strategy for therapeutic targeting of alveolar epithelial cells and macrophages in COPD

Experimental investigations of a new highly ductile hold-down with adaptive stiffness for timber seismic bracing walls

An efficient implementation of the capacity design requires high ductility combined with a low overstrength of the critical regions. Conventional timber connections do not generally offer such ideal combination, resulting in modest behaviour and relatively high overstrength factors. Inspired by the Buckling Restrained Brace a new hold-down has been developed where the timber wall directly acts as a casing. The new hold-down has been given an adaptive stiffness allowing the structure to be stiff in the wind, while becoming more flexible in the case of an earthquake. Furthermore, local crushing of the timber members is completely avoided, and the new hold-down could be replaced after an earthquake. Experimental investigations were performed on hold-down specimens. The results show ultimate displacement values vu,c of more than 30 mm in a cyclic test according to EN12512. Eleven Cross Laminated Timber shear walls, in which the new hold-down has been implemented, were tested following monotonic and static-cyclic tests procedures, with and without vertical load. A very high ductility has been achieved with almost no strength degradation, little pinching and limited overstrength

Bandwidth-controlled Mott transition in κ−(BEDT−TTF)2Cu[N(CN)2]BrxCl1−x\kappa-(BEDT-TTF)_2 Cu [N(CN)_2] Br_x Cl_{1-x} I. Optical studies of localized charge excitations

Infrared reflection measurements of the half-filled two-dimensional organic conductors $\kappa$-(BEDT-TTF)$_2$Cu[N(CN)$_{2}$]Br$_{x}$Cl$_{1-x}$ were performed as a function of temperature ($5 {\rm K}<T<300$ K) and Br-substitution ($x=0$, 40%, 73%, 85%, and 90%) in order to study the metal-insulator transition. We can distinguish absorption processes due to itinerant and localized charge carriers. The broad mid-infrared absorption has two contributions: transitions between the two Hubbard bands and intradimer excitations from the charges localized on the (BEDT-TTF)$_2$ dimer. Since the latter couple to intramolecular vibrations of BEDT-TTF, the analysis of both electronic and vibrational features provides a tool to disentangle these contributions and to follow their temperature and electronic-correlations dependence. Calculations based on the cluster model support our interpretation.Comment: 12 pages, 12 figure

Génie parasismique appliqué aux structures en bois

Pandémie, pénurie d’électricité et tremblement de terre sont les risques les plus importants pour notre pays. La mesure préventive la plus efficace face aux tremblements de terre consiste à construire parasismique. Un groupe de chercheurs de la BFH s’attèle à rendre plus efficace la mise en oeuvre des mesures parasismiques dans la construction d’ouvrages en bois. Les lignes qui suivent présentent deux des thèmes sur lesquels travaille cette équipe, en étroite collaboration avec le secteur de la construction bois et en interaction avec l’enseignement et la postformation

Lorentz Boost Networks: Autonomous Physics-Inspired Feature Engineering

We present a two-stage neural network architecture that enables a fully autonomous and comprehensive characterization of collision events by exclusively exploiting the four momenta of final-state particles. We refer to the first stage of the architecture as Lorentz Boost Network (LBN). The LBN allows the creation of particle combinations representing rest frames. The LBN also enables the formation of further composite particles, which are then transformed into said rest frames by Lorentz transformation. The properties of the composite, transformed particles are compiled in the form of characteristic variables that serve as input for a subsequent network. This second network has to be configured for a specific analysis task such as the separation of signal and background events. Using the example of the classification of ttH and ttbb events, we compare the separation power of the LBN approach with that of domain-unspecific deep neural networks (DNN). We observe leading performance with the LBN, even though we provide the DNNs with extensive additional input information beyond the particle four momenta. Furthermore, we demonstrate that the LBN forms physically meaningful particle combinations and autonomously generates suitable characteristic variables

The dependence of dijet production on photon virtuality in ep collisions at HERA

The dependence of dijet production on the virtuality of the exchanged photon, Q^2, has been studied by measuring dijet cross sections in the range 0 < Q^2 < 2000 GeV^2 with the ZEUS detector at HERA using an integrated luminosity of 38.6 pb^-1. Dijet cross sections were measured for jets with transverse energy E_T^jet > 7.5 and 6.5 GeV and pseudorapidities in the photon-proton centre-of-mass frame in the range -3 < eta^jet <0. The variable xg^obs, a measure of the photon momentum entering the hard process, was used to enhance the sensitivity of the measurement to the photon structure. The Q^2 dependence of the ratio of low- to high-xg^obs events was measured. Next-to-leading-order QCD predictions were found to generally underestimate the low-xg^obs contribution relative to that at high xg^obs. Monte Carlo models based on leading-logarithmic parton-showers, using a partonic structure for the photon which falls smoothly with increasing Q^2, provide a qualitative description of the data.Comment: 35 pages, 6 eps figures, submitted to Eur.Phys.J.