Generalized thermodynamics of q-deformed bosons and fermions

We study the thermostatistics of q-deformed bosons and fermions obeying the symmetric algebra and show that it can be built on the formalism of q-calculus. The entire structure of thermodynamics is preserved if ordinary derivatives are replaced by an appropriate Jackson derivative. In this framework, we derive the most important thermodynamic functions describing the q-boson and q-fermion ideal gases in the thermodynamic limit. We also investigate the semi-classical limit and the low temperature regime and demonstrate that the nature of the q-deformation gives rise to pure quantum statistical effects stronger than undeformed boson and fermion particles.Comment: 8 pages, Physical Review E in pres

Quantum energy flow in mesoscopic dielectric structures

We investigate the phononic energy transport properties of mesoscopic, suspended dielectric wires. The Landauer formula for the thermal conductance is derived and its universal aspects discussed. We then determine the variance of the energy current in the presence of a steady state current flow. In the final part, some initial results are presented concerning the nature of the temperature fluctuations of a mesoscopic electron gas thermometer due to the absorption and emission of wire phonons.Comment: 20 pages, 2 figures. Submitted to Phys. Rev.

A efetividade do direito fundamental ao acesso à informação e seu papel na proteção da população em tempos de pandemia: um estudo a partir do cenário brasileiro no enfrentamento da Covid-19

O presente trabalho propõe-se à investigação do direito fundamental ao acesso à informação e de sua eficácia jurídica e social no contexto mundial da pandemia de Covid-19. Toma-se por referência o contexto brasileiro, em que estaria consagrado como direito voltado majoritariamente ao controle e otimização da máquina pública e suas ações. Diante das ameaças do novo coronavírus, explora-se o direito fundamental ao acesso à informação a partir da perspectiva de promoção à autodeterminação individual. Para tanto, empreende-se a revisão da teoria dos direitos fundamentais, mas também investigação empírica da conjuntura hodierna a partir de dados e estudos disponibilizados em meio digital. Assim, vê-se que a otimização eficacial do direito à informação faz-se imprescindível à proteção de outros direitos fundamentais, como saúde, segurança, liberdade e vida, sobretudo diante das incertezas da pandemia. Através da pesquisa doutrinária e documental, valendo-se da análise comparativa de tratamentos normativos e do método dedutivo-indutivo, foram destacadas reflexões quanto às diversas problemáticas jurídicas que o corte epistemológico provoca, especialmente, quanto aos caminhos de efetivação da dignidade humana e de resguardo à autodeterminação individual e coletiva instrumentalizados pelo acesso à informação e seus elementos essenciais: comunicação e o conhecimento.

A Project Module of E-Commerce Planning

The development of a pedagogy that integrates scholastic knowledge and practical skills of e-commerce for business students is imperative. Students typically learn e-commerce planning through course projects. This note provides tips for designing and teaching an e-commerce planning project module for the e-commerce course

Location, location, location: contextualizing workplace commitment

The purpose of the present commentary is to discuss the nature and correlates of workplace commitment across cultures. We asked six organizational behavior scholars, who are intimately familiar with Brazil, China, Denmark, Germany, or Israel as their country of origin or extended residence, to “contextualize” workplace commitment. They did so by explicating institutional and cultural characteristics of their context on the emergence, meaning, and evolution of commitment by reference to their own research and extant local research. Their responses not only supported the utility of three-component model of commitment but also revealed the differential salience of various commitment constructs (e.g., components and foci of commitment) as well as possible contextual moderators on the development and outcomes of commitment. The commentators also described changes including the growing prevalence of multicultural workforces within national borders and changes in employment relationships and cultural values in their national contexts and considered future research directions in culture and commitment research

Limited effect of chronic valproic acid treatment in a mouse model of Machado-Joseph disease

Machado-Joseph disease (MJD) is an inherited neurodegenerative disease, caused by a CAG repeat expansion within the coding region of ATXN3 gene, and which currently lacks effective treatment. In this work we tested the therapeutic efficacy of chronic treatment with valproic acid (VPA) (200mg/kg), a compound with known neuroprotection activity, and previously shown to be effective in cell, fly and nematode models of MJD. We show that chronic VPA treatment in the CMVMJD135 mouse model had limited effects in the motor deficits of these mice, seen mostly at late stages in the motor swimming, beam walk, rotarod and spontaneous locomotor activity tests, and did not modify the ATXN3 inclusion load and astrogliosis in affected brain regions. However, VPA chronic treatment was able to increase GRP78 protein levels at 30 weeks of age, one of its known neuroprotective effects, confirming target engagement. In spite of limited results, the use of another dosage of VPA or of VPA in a combined therapy with molecules targeting other pathways, cannot be excluded as potential strategies for MJD therapeuticsPM received funding from Ataxia UK Grant (Project: Pharmacologic therapy for Machado-Joseph disease: from a C. elegans drug screen to a mouse model validation). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.info:eu-repo/semantics/publishedVersio

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL

Thanks to modern treatment with all-trans retinoic acid and chemotherapy, acute promyelocytic leukemia (APL) is now the most curable type of leukemia. However, this progress has not yielded equivalent benefit in developing countries. the International Consortium on Acute Promyelocytic Leukemia (IC-APL) was established to create a network of institutions in developing countries that would exchange experience and data and receive support from well-established US and European cooperative groups. the IC-APL formulated expeditious diagnostic, treatment, and supportive guidelines that were adapted to local circumstances. APL was chosen as a model disease because of the potential impact on improved diagnosis and treatment. the project included 4 national coordinators and reference laboratories, common clinical record forms, 5 subcommittees, and laboratory and data management training programs. in addition, participating institutions held regular virtual and face-to-face meetings. Complete hematological remission was achieved in 153/180 (85%) patients and 27 (15%) died during induction. After a median follow-up of 28 months, the 2-year cumulative incidence of relapse, overall survival (OS), and disease-free survival (DFS) were 4.5%, 80%, and 91%, respectively. the establishment of the IC-APL network resulted in a decrease of almost 50% in early mortality and an improvement in OS of almost 30% compared with historical controls, resulting in OS and DFS similar to those reported in developed countries.American Society of HematologyFondazione Umberto VeronesiRoche Saudi ArabiaFundacao de Apoio a Pesquisa do Estado de São PauloFundacion Mexicana para la SaludSt. Jude Children's Research HospitalCephalon EuropeUniv São Paulo, Hematol Oncol Div, Dept Internal Med, Med Sch Ribeirao Preto, BR-14048900 Ribeirao Preto, BrazilUniv São Paulo, Ctr Cell Based Therapy, BR-14048900 Ribeirao Preto, BrazilDana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USAClin Ruiz Puebla, Puebla, MexicoHosp Salvador, Dept Hematol, Santiago, ChileAsociac Espanola Primera Socorros Mutuos, Montevideo, UruguayHosp Univ Dr Jose E Gonzalez, Div Hematol, Monterrey, MexicoFundacao HEMOPE, Recife, PE, BrazilUniv Fed Rio Grande do Sul, Div Hematol, Porto Alegre, RS, BrazilUniv Fed Parana, Div Hematol, BR-80060000 Curitiba, Parana, BrazilUniv Campinas UNICAMP, Hematol & Hemotherapy Ctr, Campinas, BrazilUniv Fed Minas Gerais, Div Hematol, Belo Horizonte, MG, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilSanta Casa Med Sch, Div Hematol, São Paulo, BrazilCtr Med Nacl Siglo XXI, Mexico City, DF, MexicoNorthwestern Univ, Feinberg Sch Med, Hematol Oncol Div, Chicago, IL 60611 USAAlbert Einstein Canc Ctr, New York, NY USAUniv Med Ctr, Dept Pediat & Adolescent Med, Freiburg, GermanyStanford Univ, Dept Med, Stanford, CA 94305 USAMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, Weill Cornell Med Coll, New York, NY 10021 USAKings Coll London Sch Med, Dept Med & Mol Genet, London, EnglandHannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, GermanyHarvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USASt Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USAUniv Roma Tor Vergata, Dept Biopathol, Rome, ItalySanta Lucia Fdn, Rome, ItalyErasmus MC, Dept Hematol, Rotterdam, NetherlandsValencia Univ Med Sch, Hosp Univ La Fe, Dept Hematol, Valencia, SpainUniversidade Federal de São Paulo, São Paulo, BrazilFundacao de Apoio a Pesquisa do Estado de São Paulo: 1998/14247-6Web of Scienc