The Big Squeeze: State of Book Publishing and Academic Libraries

Presentation at the 2014 Charleston Conference: Issues is Book and Serial PublicationsIn 2014, the University of Michigan Business School Library (Kresge Business Administration Library) emptied its shelves of books in a project that will forever change library support for the school’s research needs. No longer will the library be format agnostic in acquiring resources; only online resources will be purchased. How did this happen and what does it mean for the future of the library? More importantly, what may this suggest for other libraries? What does this mean for the future of publishers and vendors? If the library is not going to buy any print books, then the rationale of current models is seriously challenged if not entirely inadequate. Publishers and libraries operate under fiscal and physical conditions that drive them further and further from mutually beneficial arrangements towards ones which are not sustainable nor good for either side. Gone are the days when we thought first and foremost about a quality item that would stand the test of time on our shelves. Instead, we are interested only in our immediate value and extracting value from others in the Information Supply Chain (or circle as many would argue). With these changes on nearly every participant in the scholarly communication space, it is very clear that we are all being squeezed in a tight spot. This session will seek to identify and potentially find a common path where we can build a future that works for everyone. Leading the discussion will be a library director dealing with severe restrictions, a Sales Director from an academic publisher (also specializing in Business), and a representative from a major academic library book distributor Each party will provide a view from their desk that showcases a way that we might find some much needed breathing room in an increasingly small space. We hope you’ll join us for what we’re sure will be a very lively discussion.http://deepblue.lib.umich.edu/bitstream/2027.42/109392/1/BigSqueeze_Barilla_Seeman_Zeoli_Final.ppthttp://deepblue.lib.umich.edu/bitstream/2027.42/109392/2/BigSqueeze_Barilla_Seeman_Zeoli_Final.pptxhttp://deepblue.lib.umich.edu/bitstream/2027.42/109392/3/BigSqueeze_Barilla_Seeman_Zeoli_Final.pdfDescription of BigSqueeze_Barilla_Seeman_Zeoli_Final.ppt : PowerPoint File (ppt)Description of BigSqueeze_Barilla_Seeman_Zeoli_Final.pptx : PowerPoint File (pptx)Description of BigSqueeze_Barilla_Seeman_Zeoli_Final.pdf : Slide Handouts (pdf

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001.

Neuroendocrine tumors (NETs) are grouped together as a single class on the basis of histologic appearance, immunoreactivity for the neuroendocrine markers chromogranin A and synaptophysin, and potential secretion of hormones, neurotransmitters, neuromodulators and neuropeptides. Nevertheless, despite these common characteristics, NETs differ widely in terms of their natural histories: high-grade NETs are clinically aggressive and, like small cell lung cancer, which they most closely resemble, tend to respond to cisplatin and etoposide. In contrast, low-grade NETs, which as a rule progress and behave indolently, do not. In either case, the treatment strategy, apart from potentially curative surgical resection, is very poorly defined. This report describes the case of a 28-year-old white male with a diagnosis of high-grade NET of undetermined primary site metastatic to the lymph nodes, skin and paraspinal soft tissues, treated with the experimental anticancer agent RRx-001, in the context of a phase II clinical trial called TRIPLE THREAT (NCT02489903); serial sampling of tumor material through repeat biopsies demonstrated an intratumoral inflammatory response, including the amplification of infiltrating T cells, which correlated with clinical and symptomatic benefit. This case suggests that pseudoprogression or RRx-001-induced enlargement of tumor lesions, which has been previously described for several RRx-001-treated patients, is the result of tumoral lymphocyte infiltration

Alien Registration- Corey, Mary (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/14377/thumbnail.jp

Piloted Simulation Assessment of the Impact of Flexible Structures on Handling Qualities of Generic Supersonic Aircraft

The NASA Langley Research Center Cockpit Motion Facility (CMF) was used to conduct a piloted simulation assessment of the impact of flexible structures on flying qualities. The CMF was used because of its relatively high bandwidth, six degree-of-freedom motion capability. Previous studies assessed and attempted to mitigate the effects of multiple dynamic aeroservoelastic modes (DASE). Those results indicated problems existed, but the specific cause and effect was difficult to ascertain. The goal of this study was to identify specific DASE frequencies, damping ratios, and gains that cause degradation in handling qualities. A generic aircraft simulation was developed and designed to have Cooper-Harper Level 1 handling qualities when flown without DASE models. A test matrix of thirty-six DASE modes was implemented. The modes had frequencies ranging from 1 to 3.5 Hz and were applied to each axis independently. Each mode consisted of a single axis, frequency, damping, and gain, and was evaluated individually by six subject pilots with test pilot backgrounds. Analysis completed to date suggests that a number of the DASE models evaluated degrade the handling qualities of this class of aircraft to an uncontrollable condition

Matilda Joslyn Gage: Writing and Righting the History of Woman Suffrage

The information in this article is drawn from the writings, correspondence, newspapers, and speeches, etc. of the woman suffrage movement housed and on microfilm in the following archival collections: The Matilda Joslyn Gage Papers, Women\u27s Studies Manuscript Collections, Schlesinger Library; The Records of the National American Woman Suffrage Association, Manuscript Division of the Library of Congress; The Papers of Elizabeth Cady Stanton and Susan B. Anthony, edited by Patricia G. Holland and Ann D. Gordon; and the Papers of the New York State Woman Suffrage Association, Rare Books and Manuscripts Division, Columbia University

Counter and Complicit Masculine Discourse Among Men’s Shed Members

Men’s Sheds is a growing international movement aimed at providing men with places and activities that facilitate social connectedness. Despite Men’s Sheds’ focus on males, little attention has been paid to masculinities within the specific context of these settings. The current study used a gender relations framework to explore the ways in which attendees discussed Men’s Sheds, with particular attention to discussions that were complicit and counter to traditional, hegemonic views of masculinity, and diverse positions in between these binaries. The data consisted of transcripts and field notes from four focus groups comprised of mostly older, White, retired male members of a Canadian shed (N = 22). The analysis revealed three overall themes: (1) focus on work, (2) independence, and (3) need for male-focused spaces. These themes and associated subthemes suggest that shed members ascribe to dominant masculine values and ideals, but also support more fluid and flexible views of masculinity. Implications are discussed for how working with an array of masculinities within the Men’s Sheds movement will be helpful with respect to their future growth in Canada and internationally

SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study).

BackgroundS1400B is a biomarker-driven Lung-MAP substudy evaluating the phosphatidylinositol 3-kinase (PI3K) inhibitor taselisib (GDC-0032) in patients with PI3K pathway-activated squamous NSCLC (sqNSCLC).MethodsEligible patients had tumoral phosphatidylinositol-4,5-biphosphate 3 kinase catalytic subunit alpha (PIK3CA) alterations by next-generation sequencing and disease progression after at least one line of platinum-based therapy. Patients received 4-mg taselisib orally daily. The primary analysis population (PAP) was a subset of patients having substitution mutations believed to be associated with clinical benefit of PI3K inhibitors. Primary endpoint was response by Response Evaluation Criteria in Solid Tumors version 1.1; secondary endpoints included progression-free survival, overall survival and duration of response.ResultsTwenty-six patients treated with taselisib comprised the full evaluable population (FEP); 21 patients comprised the PAP. Median age for patients in the FEP was 68 years (range: 53-83 years), 19 were male (73%). The study was closed for futility at interim analysis with one responder in the PAP (5% response rate, 95% confidence interval [CI]: 0%-24%). Two possibly treatment-related deaths (one respiratory failure, one cardiac arrest) were observed; one patient had grades 4 and 11 had grade 3 adverse events. Median progression-free survival and overall survival in the PAP group were 2.9 months (95% CI: 1.8-4.0 mo) and 5.9 months (95% CI: 4.2-7.8 mo), respectively. These numbers were nearly the same in the FEP.ConclusionsStudy S1400B evaluating taselisib in PIK3CA-altered sqNSCLC failed to meet its primary endpoint and was closed after an interim futility analysis. The trial is unique in cataloguing the diversity of PIK3CA mutations in sqNSCLC