Das Begehren der Philologie nach räumlichen Beziehungen

In response to the question "What is the nature of a philological practice that seeks to establish a spatial relationship between text and reader?" this essay compares the philologist Hans Ulrich Gumbrecht's contemporary account of aesthetic experience with the school of Empathy Aesthetics in the late nineteenth century with respect to the manner each emphasizes the spatial qualities of that relationship. Although employing different conceptual repertoires, both assert that the desire of an aesthetic recipient to be in the spatial vicinity of the object and experience the presence of the object with and upon his own body motivates an aesthetic experience, including the work of the philologist. Gumbrecht and the empathy aesthetician Robert Vischer characterize the desire to stand in a spatial relationship to the aesthetic object as the desire to be subsumed thereby, a characterization which entails the negation of the original philological standpoint

Use of complementary and alternative medicine in Hawaii cancer patients.

This research investigated complementary and alternative medicine (CAM) use by Hawaii cancer patients. Thirty-six percent of patients used CAM, most commonly religious/spiritual therapy and herbal treatments. CAM use was linked with younger age, female gender, Catholic religion, and more education. More research is needed to inform decision-making.R01 CA 61711/CA/NCI NIH HHS/United StatesR01 CA 64045/CA/NCI NIH HHS/United State

Quantifying cellular traction forces in three dimensions

Cells engage in mechanical force exchange with their extracellular environment through tension generated by the cytoskeleton. A method combining laser scanning confocal microscopy (LSCM) and digital volume correlation (DVC) enables tracking and quantification of cell-mediated deformation of the extracellular matrix in all three spatial dimensions. Time-lapse confocal imaging of migrating 3T3 fibroblasts on fibronectin (FN)-modified polyacrylamide gels of varying thickness reveals significant in-plane (x, y) and normal (z) displacements, and illustrates the extent to which cells, even in nominally two-dimensional (2-D) environments, explore their surroundings in all three dimensions. The magnitudes of the measured displacements are independent of the elastic moduli of the gels. Analysis of the normal displacement profiles suggests that normal forces play important roles even in 2-D cell migration

Leptin, adiponectin, and obesity among Caucasian and Asian women.

Ethnic differences in adipose tissue distribution may contribute to different chronic disease risks across ethnic groups, and adipokines may mediate the risk. In a cross-sectional study, we examined ethnic differences in adipokines and inflammatory markers as related to body mass index (BMI) among 183 premenopausal women with Caucasian and Asian ancestry. General linear models were used to estimate adjusted mean levels of leptin, adiponectin, interleukin-6, and C-reactive protein (CRP). Asian women had significantly lower serum levels of leptin, adiponectin, and CRP than Caucasian participants (P≤.01) across all levels of BMI. Among overweight and obese women, Asians showed a stronger association of CRP with leptin (β=1.34 versus β=0.64) and with adiponectin (β=-0.95 versus β=-0.75) than Caucasians. Compared to Caucasians of similar BMI, Asians may experience a higher chronic disease risk due to lower levels of adiponectin despite their lower levels of leptin

Associations between obesity and serum lipid-soluble micronutrients among premenopausal women.

Elucidating potential pathways that micronutrients may reduce/promote chronic disease may contribute to our understanding of the underlying etiology of disease and their utility as markers of risk. In the current study, we examined associations of serum lipid-soluble micronutrients with body mass index (BMI). We hypothesized that obesity may differentially influence serum micronutrient levels, thereby affecting risk for chronic disease incidence and mortality. Baseline serum samples from 180 premenopausal women from a nutritional trial were analyzed for leptin, C-reactive protein, 25-hydroxyvitamin D, carotenoids, and tocopherols. Participants were stratified into normal-weight (18.5-24.9), overweight (25-29.9), and obese (>or=30) subgroups by BMI (in kilograms per square meter). Differences in serum biomarkers among BMI subgroups were adjusted for Asian ethnicity and smoking status. As expected, obese individuals had significantly higher serum levels of leptin and C-reactive protein (Ps < .05) compared with normal-weight women. gamma-Tocopherol levels were significantly higher in obese individuals (P < .05), whereas alpha-tocopherol levels did not differ among BMI subgroups. Serum levels of 25-hydroxyvitamin D and carotenoids (except lycopene) were significantly lower in obese than in normal-weight women (Ps < .05). The associations between BMI and carotenoids were independent of dietary intake. The obesity-associated reduction for total provitamin A carotenoids (45%) was approximately 3-fold greater than that observed for non-provitamin A carotenoids (16%). Our results indicate potential influences of obesity on serum levels of lipid-soluble micronutrients and suggest that metabolism of provitamin A carotenoids may contribute to the differences observed

Lithographic Patterning of Photoreactive Cell-Adhesive Proteins

We describe a novel, simple method for the photolithographic patterning of cell-adhesive proteins. Intrinsically photoreactive proteins are synthesized in Escherichia coli through incorporation of the non-canonical, photosensitive amino acid para-azidophenylalanine. Upon ultraviolet irradiation at 365 nm, proteins form cross-linked films with elastic moduli that can be tuned by varying the concentration of photoreactive amino acid in the expression medium. Films of these proteins can be directly patterned using standard photolithographic techniques. We demonstrate the utility of this method of protein patterning by creating stable arrays of fibroblast cells on an engineered protein “photoresist”

Nuns as ‘Sponsae Christi’: The Legal Status of the Medieval Oblates of Tor de’ Specchi

Francesca Roman

Monastic Archives and the Law: Legal Strategies at Farfa and Monte Amiata at the Turn of the Millennium

This article investigates two controversies that reveal the deeply intertwined nature of legal strategies and archival practices at the monasteries of Farfa and Monte Amiata around the turn of the millennium. It argues that the protagonists of these cases, abbots knowledgeable in law and the history of their monasteries, pursued markedly historical legal strategies: legal strategies that looked to, manipulated, and, above all, contextualized, archival documents in order to make legal arguments. This sheds light on early medieval monastic legal culture in north-central Italy and provides insights into the rationale for monastic forgeries of documentary materials at Monte Amiata

Strategic voting in the Hungarian elections of 2014: evidence for Duverger's law under the compensatory mixed electoral system?

This article tests Duverger's law through an analysis of the Hungarian parliamentary elections of 2014 which were held under the new compensatory mixed electoral system. The results show that while a strategic voting had a tendency to grow under Hungarian supermixed system in the period 1990-2010, in the elections of 2014 strategic voting was not a universal phenomenon under the plurality rule, as indicated by many violations of Duverger’s law in Hungarian singlemember districts. Our research confirmed that the effect of electoral institutions (institutional structure) is contingent and at the district level inhibited by country-specific conditions. However, as a new Hungarian compensatory mixed electoral system distributes seats not only by plurality rule in SMDs (nominal tier), but also via proportional representation (list tier), a further research should pay attention to crosscontamination of both tiers of electoral system, as a potential factor which moves Hungarian electoral competition substantially away from Duvergerian predictions