2-Amino­pyrimidin-1-ium 4-methyl­benzene­sulfonate

In the crystal structure of the title compound, C4H6N3 +·C7H7O3S−, inter­molecular N—H⋯O hydrogen bonds link the cations and anions into chains along [100]. Additional stabilization is provided by weak C—H⋯O hydrogen bonds. An inter­molecular π–π stacking inter­action with a centroid–centroid distance of 3.6957 (7) Å is also observed. The H atoms of the methyl group were refined as disordered over two sets of sites with equal occupancie

Bis(guanidinium) tris­(pyridine-2,6-dicarboxyl­ato-κ3 O 2,N,O 6)zirconate(II) tetra­hydrate

In the title complex, (CH6N3)2[Zr(C7H3NO4)3]·4H2O, the ZrIV ion lies on a twofold rotation axes and is coordinated by six O and three N atoms of three tridentate pyridine-2,6-dicarboxyl­ate ligands, forming a slightly distorted tricapped trigonal–prismatic geometry. In the crystal, O—H⋯O and N—H⋯O hydrogen bonds link the components into a three-dimensional network

Tetra­kis(2-amino-4-methyl­pyridinium) cyclo-tetra-μ2-oxido-tetra­kis­[dioxido­vanadate(V)] tetra­hydrate

The asymmetric unit of the title compound, (C6H9N2)4[V4O12]·4H2O, contains half of a [V4O12]4− anion, two 2-amino-4-methyl­pyridinium, (2a4mpH)+, cations and two water mol­ecules. One water mol­ecule is disordered over two sets of sites with equal occupancies and the H atoms for this mol­ecule were not included in the refinement. The cation lies on an inversion center with four tetra­hedral VO4 units each sharing two vertices, forming an eight-membered ring. In the crystal, the components are linked by inter­molecular N—H⋯O hydrogen bonds, forming a one-dimensional network along [100]. Further stabilization is provided by weak inter­molecular C—H⋯O hydrogen bonds. In addition, π–π stacking inter­actions with centroid–centroid distances of 3.5420 (18), 3.7577 (18) and 3.6311 (19) Å are observed

Eth­oxy­carbonyl­methyl 3-(4-chloro­benzyl­idene)dithio­carbazate

Mol­ecules of the title compound, C12H13ClN2O2S2, are linked into centrosymmetric dimers by pairs of inter­molecular N—H⋯S hydrogen bonds. In the crystal structure, there are π–π stacking inter­actions between symmetry-related benzene rings with a centroid–centroid distance of 3.7305 (13) Å, a perpendicular distance between the planes of 3.2851 (9) Å and a slippage of 1.768 Å. The structure is further stabilized by weak inter­molecular C—H⋯O hydrogen bonds

1-(2-Pyrid­yl)-N,N′-dipyrimidin-2-ylmethane­diamine

In the title compound, C14H13N7, inter­molecular N—H⋯N and C—H⋯N hydrogen bonds link the mol­ecules into infinite one-dimensional chains along (100). A C—H⋯π inter­action also occurs in the crystal

N,N′-(4-Chloro­benzyl­idene)dipyrimidin-2-amine

The title compound, C15H13ClN6, contains two pyrimidine rings and one benzene ring, where the dihedral angle between the planes through the pyrimidine rings is 81.57 (10)°, and those between the pyrimidine rings and the benzene ring are 84.02 (8) and 89.46 (7)°, indicating that the three rings are almost perpendicular. In the crystal, inter­molecular N—H⋯N hydrogen bonds link the mol­ecules into infinite chains along (100)

4-Methyl-N-[(E)-4-methyl-1-(4-methyl­phenyl­sulfon­yl)-1,2-dihydropyridin-2-yl­idene]benzene­sulfonamide

The reaction of 2-(amino­meth­yl)pyridine and 4-toluene­sulfonyl chloride in CH2Cl2 at pH 8 led to the title compound, C20H20N2O4S2. The aromatic rings are almost perpendicular to each other and the dihedral angles between the aromatic ring planes are 74.33 (9) (central pyridine versus benzene ring of the tosyl group bonded to the imine functionality), 73.77 (6) (pyridine versus benzene ring of the tosyl group bonded to pyridinic N atom) and 79.83 (9)° (benzene rings of tosyl groups). In the crystal structure, inter­molecular aromatic π–π stacking inter­actions [centroid–centroid separation = 3.6274 (14) Å] help to consolidate the packing

Hydrothermal synthesis and characterization of a binuclear complex and a coordination polymer of copper(II)

Two new copper complexes [(bipy)(pydc)Cu(µ-OCO-pydc)Cu(bipy)(H2O)].3.5H­2O (1) and {[(µ2-C2O4)(2,2'-bipy)Cu].2H2O}n (2) (pydcH2 = pyridine-2,6-dicarboxylilic acid, bipy = 2,2'-bipyridine) have been hydrothermally synthesized. Both complexes were characterized by IR spectroscopy, elemental analysis and single crystal X-ray diffraction studies. Complex 1 consists of two independent neutral molecules. In every moiety, metal ion center is in a distorted octahedral geometry. Coordination polymer (2) has been prepared from the reaction of bis-(cyclohexanone)-oxal-dihydrazone,2,2'-bipyridine and Cu(NO3)2 in basic solution and under hydrothermal condition. The results showed that the bis-(cyclohexanone)-oxal-dihydrazone was converted to oxalate ion under heating and basic pH. Each metal ion center in 2 is in a distorted octahedral geometry and is coordinated by four oxygen atoms of two bridged oxalate ions and two nitrogen atoms of 2,2'-bipyridine molecules. In the crystal structure of 2, some H-bonds and π-π interaction cause formation of a 3D network. KEY WORDS: Hydrothermal synthesis, Cu complex, Coordination polymer, Crystal structure  Bull. Chem. Soc. Ethiop. 2010, 24(3), 401-409

The Study of Cytotoxicity of an Imidazolium Based Ionic Liquid on MCF-7 Cell Line

Ionic liquids are liquid in wide range and could be applied in many fields. These compounds can be used as solvents for inorganic and organic synthesis and show biological activities. 1-ethyl-3-Methylimidazolium bromide (1) as an ionic liquid has been synthesized from the reaction of 1-methylimidazole and ethylbromide in toluene as solvent and under refluxed condition. The prepared compound was characterized by 1H-NMR, IR spectroscopy and elemental analyses. The effect of cytotoxicity of -ethyl-3-Methylimidazolium bromide (ion liquid)on the MCF-7 cell line has been investigated. The cytotoxic activity of synthesis compound was assessed by the MTT colorimetric method in vitro assay performed in human MCF-7 breast carcinoma cell line. Dose effect of compound was investigated and results showed that the cytotoxic effect was dose-dependent. The decrease of concentration of ion liquid was followed by markedly increase of tumor cell viability. The cytotoxicity of 1-ethyl-3-Methylimidazolium bromide, expressed as IC50 values after 48 h incubation. This value was 2.91 mM for mcf-7 cell line

2-Amino-4-methyl­pyridinium 6-carb­oxy­pyridine-2-carboxyl­ate sesquihydrate

In the title compound, C6H9N2 +·C7H4NO4 −·1.5H2O, extensive O—H⋯O, O—H⋯N, N—H⋯O and C—H⋯O hydrogen bonds, as well as ion pairing, π–π stacking inter­actions [centroid–centroid distances = 3.4690 (8) and 3.6932 (8) Å between aromatic rings] occur in the crystal. There are hydrogen-bonding inter­actions between water mol­ecules, which result in cyclic tetra­meric water clusters. One of the water O molecules has half occupancy. In the anion molecules, the –CO2 and –CO2H groups make torsion angles of 1.73 (18) and −12.14 (18)° with respect to the ring