14 research outputs found
Inégalité et croissance économique: quelles implications pour les pays développés et les pays en développement à l'ère de la mondialisation?
Inégalité et croissance économique: quelles implications pour les pays développés et les pays en développement à l'ère de la mondialisation?
Language and Philosophy, from Frege to the Present
International audienceThis chapter, by four authors, traces the rise, development, critique, and demise of a diversity of theoretical stances in philosophy and linguistic meaning from 1880-2000, e.g., — modern logic, formal semantics, the linguistic turn in philosophy, truth-conditional semantics, intensional logic, possible world-semantics, categorial (Montague) grammar and ‘generalized quantifiers’; — logical positivism and its critiques, ‘analytic’ statements, ‘radical interpretation’, ‘truth-theoretical semantics’, ‘proof-theoretical semantics’; — psychological accounts of meaning, communitarian agreement; proper names as ‘rigid designators’; reference fixing vs. the properties of a ‘kind’ in all possible worlds; — the ‘cognitive’ era: meaning as a property of mental states (’concepts’), the philosophy of mind, the naturalization program, intentional generalizations with a computationalist view, ‘narrow’ and ‘broad’ concepts of meaning, and the functions of informational structures. — Speech Act Theory and pragmatics: ‘ordinary language philosophy’; performance in a context, felicity conditions, intentional and conventional aspects, communicative intentions, conventional meanings, the Cooperative principle, and inferences from conversational implicatures; presumption of rationality, ‘relevance theory’, combining pragmatics and a theory of mind; Discourse Analysis (Birmingham and Geneva School); enunciation theory; intersubjectivity; ‘polyphonic’ notion of subject, argumentative values, scales, and beliefs, Topoi Theory and the ‘theory of semantic blocks’
Variability of the monthly European temperature and its association with the Atlantic sea-surface temperature from interannual to multidecadal scales
Is the Slow Vital Capacity Clinically Useful to Uncover Airflow Limitation in Subjects With Preserved FEV1/FVC Ratio?
Spirometric indices of early airflow impairment in individuals at risk of developing COPD: Spirometry beyond FEV1/FVC
Spirometry is the current gold standard for diagnosing and monitoring the progression of Chronic Obstructive Pulmonary Disease (COPD). However, many current and former smokers who do not meet established spirometric criteria for the diagnosis of this disease have symptoms and clinical courses similar to those with diagnosed COPD. Large longitudinal observational studies following individuals at risk of developing COPD offer us additional insight into spirometric patterns of disease development and progression. Analysis of forced expiratory maneuver changes over time may allow us to better understand early changes predictive of progressive disease. This review discusses the theoretical ability of spirometry to capture fine pathophysiologic changes in early airway disease, highlights the shortcomings of current diagnostic criteria, and reviews existing evidence for spirometric measures which may be used to better detect early airflow impairment
Spirometric indices of early airflow impairment in individuals at risk of developing COPD: Spirometry beyond FEV1/FVC
Spirometry is the current gold standard for diagnosing and monitoring the progression of Chronic Obstructive Pulmonary Disease (COPD). However, many current and former smokers who do not meet established spirometric criteria for the diagnosis of this disease have symptoms and clinical courses similar to those with diagnosed COPD. Large longitudinal observational studies following individuals at risk of developing COPD offer us additional insight into spirometric patterns of disease development and progression. Analysis of forced expiratory maneuver changes over time may allow us to better understand early changes predictive of progressive disease. This review discusses the theoretical ability of spirometry to capture fine pathophysiologic changes in early airway disease, highlights the shortcomings of current diagnostic criteria, and reviews existing evidence for spirometric measures which may be used to better detect early airflow impairment.status: publishe
Myeloid cell networks determine reinstatement of original immune environments in recurrent ovarian cancer
Myeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancer
Immunotherapy has shown limited success in recurrent ovarian cancer (OC), with prognostic insights largely derived from treatment-naive tumors. We analyzed 697 tumor samples (566 primary and 131 recurrent) from 595 OC patients across five independent cohorts, capturing tumor-infiltrating lymphocytes (TILs) heterogeneity and identifying four immune phenotypes linked to prognosis and TIL:myeloid networks driving malignant progression. We found that in preclinical mouse models, mirroring inflamed human OCs, the recurrent Brca1mut tumors maintained activated TILs:dendritic cells (DCs) niches but evaded immune control through upregulation of COX/PGE2 signaling. Conversely, recurrent Brca1wt tumors displayed loss of TILs:DCs niches and accumulated immunosuppressive tumor microenvironment (TME) networks featuring Trem2/ApoEhigh tumor associated macrophages (TAMs) and Nduf4l2high/Galectin3high malignant states. Recurrent tumors recapitulate the immunogenic landscapes of original cancers. Our findings reveal BRCA-dependent TIL:myeloid crosstalk as key to persistent immunogenicity in recurrent OC and propose new targets to enhance chemotherapy efficacy
