Simulation analysis of performances and yield rates on a lens module

A simulation platform is developed to analyze the tolerance ability of designed lens in the opto-mechanical system. The major task of lens designer is to find out the optimal parameters to meet the specification requirement. A real lens with decenter, tilt, and lens parameters’ variation could lower the performance of lens. The original parameters from the lens designer suffer certain probability distribution during manufacturing lenses so that the performance of assembly lens is always different from that of the optimal design. The proposal applies a variety of probability density functions of the manufacture to obtain the tolerance parameters used in simulation. Some macros of commercial optical software based on the Monte Carlo method are developed to simulate the lens manufacture tolerance and analyze the yield rate for mass production. With proper probability density functions of the manufacture, the tolerance can be estimated from the proposed algorithm

Hypersensibilité immédiate au carboplatine ou à l’oxaliplatine : réintroduction du cisplatine sans tests cutané ?

International audienceIntroduction : L’incidence des réactions d’hypersensibilité immédiate aux sels de platine (cisplatine, carboplatine et oxaliplatine) augmente avec leur large utilisation en cancérologie. Les objectifs de cette étude étaient d’établir la fréquence des sensibilités croisées entre les sels de platine, de déterminer si le cisplatine peut être utilisé sans test allergologique préalable en cas d’allergie immédiate au carboplatine ou à l’oxaliplatine et enfin de proposer une prise en charge simple pour retraiter rapidement les malades.Méthodes : Notre étude rétrospective a porté sur 155 malades ayant présenté une réaction d’hypersensibilité immédiate à un sel de platine. Des intradermoréactions aux trois sels de platine ont été effectuées puis une réintroduction à dose d’emblée thérapeutique a ensuite été proposée en fonction du résultat des tests.Résultats : Les tests étaient positifs chez 97 des 155 patients avec le sel de platine suspecté. La fréquence de la sensibilité croisée entre carboplatine et oxaliplatine était très élevée (40 %) alors qu’elle était rare (3 %) entre le cisplatine et les autres sels. Dans les trois cas d’hypersensibilité croisée entre le cisplatine et les 2 autres ; le cisplatine avait déjà était utilisé lors de précédentes chimiothérapies. Une réintroduction du cisplatine a été réalisée chez 24 patients ayant une hypersensibilité prouvée au carboplatine ou à l’oxaliplatine sans aucun effet secondaire.Discussion : Cette étude montre sur une grande série l’intérêt diagnostique des intradermoréactions aux sels de platine et leur utilité pour guider les réintroductions, confirmant ainsi les données préalablement publiées par notre service puis d’autres travaux de la littérature. La structure chimique des trois molécules pourrait expliquer l’absence de réaction croisée entre cisplatine et oxaliplatine/carboplatine, une chaîne est commune à l’oxaliplatine et au carboplatine mais pas au cisplatine.Conclusion : Les allergies au cisplatine sont très rares et les données des tests suggèrent qu’il est possible d’utiliser cette molécule sans risque d’allergie après un accident anaphylactique au carboplatine ou à l’oxaliplatine

Impact of G-CSF Prophylaxis on Chemotherapy Dose-Intensity, Link Between Dose-Intensity and Survival in Patients with Metastatic Pancreatic Adenocarcinoma

Abstract Background In metastatic pancreatic adenocarcinoma, few data are available on the use of granulocyte-colony stimulating factor (G-CSF) prophylaxis and its impact on dose-intensity (DI), or the link between DI and progression-free survival (PFS). This study assessed the impact of G-CSF prophylaxis on the DI received by patients and the relationship between full DI and PFS according to chemotherapy regimens. Patients and Methods Patients from three first-line randomized phase II clinical trials were included in this retrospective cohort. G-CSF prophylaxis groups were identified and balanced according to baseline characteristics using a propensity score. Patients were classified into 2 treatment groups (FOLFIRINOX vs FOLFIRI/nab-paclitaxel (NAB)). DI was a binary variable (full/reduced). Adverse events were defined using NCI-CTCAE v4.0. Results Of the 498 patients, 154 (31%) were in “prophylaxis” group; 179 (36%) were treated by FOLFIRINOX and 319 (64%) by FOLFIRI/NAB. In FOLFIRINOX group, G-CSF prophylaxis was significantly associated with a higher rate of full DI (OR, 5.07; 95% CI, 1.52-16.90; P &amp;lt; .01) while in FOLFIRI/NAB group, it was significantly associated with a lower rate of full DI (OR, 0.23; 95% CI, 0.06-0.83; P = .03). Full DI was associated with a non-significant increase in PFS (FOLFIRINOX group: HR 0.83; 95% CI, 0.59-1.16; P = .27; FOLFIRI/NAB group: HR 0.84; 95% CI, 0.63-1.11; P = .22). Conclusion Granulocyte-colony stimulating factor prophylaxis was associated with a higher rate of full DI with FOLFIRINOX. Full DI was associated with a non-significant increase in PFS. These results need to be confirmed prospectively. </jats:sec

Interest of the Sol-Gel Approach for Multiscale Tailoring of Porous Bioelectrode Surfaces

International audienceGold nanoparticles have been co-encapsulated with D-sorbitol dehydrogenase and diaphorase in electrodeposited thin sol-gel films. We demonstrate here that the nanoparticles allow improving significantly the catalytic efficiency of the bioelectrodes. The hybrid material was electrodeposited in the cavities of macroporous electrodes and characterized by high-resolution transmission electron microscopy and electrochemistry. Well-defined silica gel layers containing homogeneously dispersed nanoparticles were obtained, leading to high current densities in the presence of D-sorbitol. The access to the internal porosity of the macroporous electrode was not hindered by the presence of the electrodeposited sol-gel layer. In addition, a very significant enhancement factor, that describes the current increase with the increasing macroporous surface area was obtained due to the contribution of the tridimensional gold nanoparticle network

Aflibercept-LV5FU2 as first-line treatment of non-resectable metastatic colorectal cancers: Results of the FOLFA randomized phase II trial.

3555 Background: Previous trials have demonstrated that bevacizumab and fluoropyrimidine combination is effective and well-tolerated in older patients (pts) with non-aggressive unresectable metastatic colorectal cancer. We evaluated in this trial safety and efficacy of aflibercept and infusional 5-fluorouracil/folinic acid (LV5FU2 regimen) combination versus LV5FU2 alone in older pts, asymptomatic and/or frail, deemed unsuitable for doublet cytotoxic chemotherapy. Methods: The main eligibility criteria for this randomized phase II trial were age ≥ 65 and WHO performance status &lt; 2. Randomization was stratified according to thymidylate synthase (TS)- 5’UTR germline polymorphism. Common (also called simplified) LV5FU2 regimen was preceded or not by aflibercept (4mg/kg). The primary endpoint was the 6-month progression-free survival (PFS) rate, achieved if &gt; 40% in the experimental arm. Secondary objectives were safety, quality of life, overall survival (OS), and the prognostic impact of TS -5’UTR polymorphism. Results: 117 patients (pts) were included, 59 in arm A (5FU-aflibercept), 58 in arm B (5FU alone), of median age 81 years (range 67-91; &gt; 75 years: 81%). RAS/ BRAF status (available in 112 pts [96%]) was mutated in 49% and 7%, respectively. The 6-month PFS was 54% in both arms (same 90% CI 42-65). The disease control rate was 83% in arm A and 87% in arm B. The median OS was 21.8 months in arm A and 25.1 months in arm B. The toxicities were more common in arm A: at least 1 grade 3-4 toxicity &gt; 2 in 82% versus (vs) 58.2% pts, hypertension grade &gt; 3 in 42% vs 18% pts, proteinuria (any grade) in 51% vs 11% pts, dysphonia (grade &lt; 3) in 19% vs 2%, 1 colic perforation in arm A. Treatment delays for toxicities were required for 4% of the 753 courses in arm A vs 2% of the 780 courses in arm B , 5FU bolus suppression was decided for 29.8% pts vs 20% (arm A vs arm B), median 29 days vs 73 days after the first course (arm A vs B), without difference in the doses of infusional 5FU. A second and third line of treatment were received in 41% and 14% of pts in arm A vs 67% and 29% of pts in arm B, respectively. The TS 5’UTR polymorphism (3R3R vs 2R2R or 2R3R) had no impact on PFS or OS. Regarding the quality of life (QLQ C30 score), the difference of overall health score was on average -6.39 (SD = 26.68) in arm A vs -4.91 (SD = 27.15) in arm B, and was very similar in all components. The median time to definitive deterioration in quality of life was 15 months (95% CI: 9-22.8) in arm A vs 9.6 (95% CI: 5.1-19.4) in arm B. Conclusions: FOLFA trial meets is primary endpoint with 53.6% of 6-month PFS with LV5FU2-aflibercept. Nevertheless, as compared with LV5FU2 alone we observed no increase in PFS or OS and more toxicities. These results do not argue for an evaluation of LV5FU2-aflibercept combination in a randomized phase III trial. Clinical trial information: EudraCT 2014-001837-10. </jats:p

Perioperative Cetuximab with Cisplatin and 5-Fluorouracil in Esogastric Adenocarcinoma: A Phase II Study

Purpose: While perioperative chemotherapy provides a survival benefit over surgery alone in gastric and gastroesophageal junction (G/GEJ) adenocarcinomas, the results need to be improved. This study aimed to evaluate the efficacy and safety of perioperative cetuximab combined with 5-fluorouracil and cisplatin. Patients and Methods: Patients received six cycles of cetuximab, cisplatin, and simplified LV5FU2 before and after surgery. The primary objective was a combined evaluation of the tumor objective response (TOR), assessed by computed tomography, and the absence of major toxicities resulting in discontinuation of neoadjuvant chemotherapy (NCT) (45% and 90%, respectively). Results: From 2011 to 2013, 65 patients were enrolled. From 64 patients evaluable for the primary endpoint, 19 (29.7%) had a morphological TOR and 61 (95.3%) did not stop NCT prematurely due to major toxicity. Sixty patients (92.3%) underwent resection. Sixteen patients (/56 available, 28.5%) had histological responses (Mandard tumor regression grade ≤3). After a median follow-up of 44.5 months, median disease-free and overall survival were 24.4 [95% CI: 16.4-39.4] and 40.3 months [95% CI: 27.5-NA], respectively. Conclusion: Adding cetuximab to the NCT regimen in operable G/GEJ adenocarcinomas is safe, but did not show enough efficacy in the present study to meet the primary endpoint (NCT01360086)

Evaluation des caractéristiques et de l'intérêt agronomique de préparations simples de plantes, pour des productions fruitières, légumières et viticoles économes en intrants

International audienc