Fusion rules for admissible representations of affine algebras: the case of A2(1)A_2^{(1)}

We derive the fusion rules for a basic series of admissible representations of $\hat{sl}(3)$ at fractional level $3/p-3$. The formulae admit an interpretation in terms of the affine Weyl group introduced by Kac and Wakimoto. It replaces the ordinary affine Weyl group in the analogous formula for the fusion rules multiplicities of integrable representations. Elements of the representation theory of a hidden finite dimensional graded algebra behind the admissible representations are briefly discussed.Comment: containing two TEX files: main file using input files harvmac.tex, amssym.def, amssym.tex, 19p.; file with figures using XY-pic package, 6p. Correction in the definition of general shifted weight diagra

Malnutrition impact on stroke outcome: an analysis of a patient cohort 3 months after recanalization treatment

Background: Malnutrition is thought to affect 30% to 70% of hospitalized patients. Little is known about consequences of undernutrition during the acute phase of stroke. We would like to assess the impact of pre-infarction malnutrition on stroke patients treated with thrombolysis and/ or thrombectomy. Material and methods: We performed a retrospective observational study on a cohort of stroke patients who benefited from thrombolysis and/ or thrombectomy during 2015 in Saint Joseph Hospital’s Stroke Unit. The main objective of our research was to observe the clinical course of undernourished patients compared to the non-undernourished ones, using the NIHSS score at the stroke unit discharged and the 3 months modified Rankin score. Undernutrition was defined by a body mass index of (BMI) ≤ 21. Results: A total of 81 patients with thrombolysis and/or thrombectomy treatment were included. The median BMI in < 70-year-old patients was 24.5 and 25 in > 70-year-old patients. Initial severity measured by baseline NIHSS score was comparable among the undernourished and non-undernourished patients. Undernourished patients over 70 had a more severe neurological state at discharge (NIHSS 8.5 versus 3.9, NS) and were more disabled 3 months after discharge (Rankin 3.1 versus 2, NS). Conclusions: Undernutrition prior to stroke seems to have an impact on the functional prognosis of cerebral infarction, especially in patients > 70 years of age. Lack of significant results may be explained by the limited statistical means. A complementary study with a larger cohort is planned in order to assess this hypothesis

Лечение инсульта. Обзор литературы и клинический случай.

Treatment of cerebral heart attack. Literature review and clinical case.Accidentul ischemic cerebral (AIC) sau infarctul cerebral (IC) reprezintă 80% din numărul total de accidente vasculare cerebrale (AVC), ocluzia unei/sau mai multor artere cerebrale fiind confirmată prin examene imagistice non invazive (IRM sau TC cerebrală cu sau fără injectare a substanței de contrast). Ultimele 3-4 decenii au fost revoluționare pentru tratamentul AIC, fiind puse &icirc;n aplicare: aspirina, anticoagulantele orale antivitamina K (AVK), anticoagulantele orale cu acțiune directă (AOD), tromboliza intravenoasă (TI), trombectomia (T) și hemicraniotomia decompresivă. Terapia de recanalizare prin tratament fibrinolitic intravenos și trombectomie au obiectivul de ameliorare clinică a pacientului prin reperfuzia zonei de penumbră ischemică. AIC este o urgență vitală, iar un tratament administrat rapid, adecvat și eficient semnifică nu doar viața, ci și recuperarea autonomiei pacientului - &bdquo;time is brain&rdquo;.Лечение инсульта. Обзор литературы и клинический случай

Trapping in irradiated p-on-n silicon sensors at fluences anticipated at the HL-LHC outer tracker

The degradation of signal in silicon sensors is studied under conditions expected at the CERN High-Luminosity LHC. 200 $\mu$m thick n-type silicon sensors are irradiated with protons of different energies to fluences of up to $3 \cdot 10^{15}$ neq/cm$^2$. Pulsed red laser light with a wavelength of 672 nm is used to generate electron-hole pairs in the sensors. The induced signals are used to determine the charge collection efficiencies separately for electrons and holes drifting through the sensor. The effective trapping rates are extracted by comparing the results to simulation. The electric field is simulated using Synopsys device simulation assuming two effective defects. The generation and drift of charge carriers are simulated in an independent simulation based on PixelAV. The effective trapping rates are determined from the measured charge collection efficiencies and the simulated and measured time-resolved current pulses are compared. The effective trapping rates determined for both electrons and holes are about 50% smaller than those obtained using standard extrapolations of studies at low fluences and suggests an improved tracker performance over initial expectations

Performance of Pyridylthiourea-Polyethylenimine Polyplex for siRNA-Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models

Medical application of siRNAs relies on methods for delivering nucleic acids into the cytosol. Synthetic carriers, which assemble with nucleic acids into delivery systems, show promises for cancer therapy but efficiency remains to be improved. In here, the effectiveness of pyridylthiourea‐polyethylenimine (πPEI), a siRNA carrier that favors both polyplex disassembly and endosome rupture upon sensing the acidic endosomal environment, in 3 experimental models of hepatocellular cancer is tested. The πPEI‐assisted delivery of a siRNA targeting the polo‐like kinase 1 into Huh‐7 monolayer produces a 90% cell death via a demonstrated RNA interference mechanism. Incubation of polyplex with Huh‐7 spheroids leads to siRNA delivery into the superficial first cell layer and a 60% reduction in spheroid growth compared to untreated controls. Administration of polyplexes into mice bearing subcutaneous implanted Huh‐7Luc tumors results in a reduced tumor progression, similar to the one observed in the spheroid model. Altogether, these results support the in vivo use of synthetic and dedicated polymers for increasing siRNA‐mediated gene knockdown, and their clinical promise in cancer therapeutics