Schwinger's Dynamical Casimir Effect: Bulk Energy Contribution

Schwinger's Dynamical Casimir Effect is one of several candidate explanations for sonoluminescence. Recently, several papers have claimed that Schwinger's estimate of the Casimir energy involved is grossly inaccurate. In this letter, we show that these calculations omit the crucial volume term. When the missing term is correctly included one finds full agreement with Schwinger's result for the Dynamical Casimir Effect. We have nothing new to say about sonoluminescence itself except to affirm that the Casimir effect is energetically adequate as a candidate explanation.Comment: 6 pages. Uses LaTeX with RevTeX package in two-column forma

The topomer-sampling model of protein folding

Clearly, a protein cannot sample all of its conformations (e.g., ≈3^(100) ≈ 10^(48) for a 100 residue protein) on an in vivo folding timescale (<1 s). To investigate how the conformational dynamics of a protein can accommodate subsecond folding time scales, we introduce the concept of the native topomer, which is the set of all structures similar to the native structure (obtainable from the native structure through local backbone coordinate transformations that do not disrupt the covalent bonding of the peptide backbone). We have developed a computational procedure for estimating the number of distinct topomers required to span all conformations (compact and semicompact) for a polypeptide of a given length. For 100 residues, we find ≈3 × 10^7 distinct topomers. Based on the distance calculated between different topomers, we estimate that a 100-residue polypeptide diffusively samples one topomer every ≈3 ns. Hence, a 100-residue protein can find its native topomer by random sampling in just ≈100 ms. These results suggest that subsecond folding of modest-sized, single-domain proteins can be accomplished by a two-stage process of (i) topomer diffusion: random, diffusive sampling of the 3 × 10^7 distinct topomers to find the native topomer (≈0.1 s), followed by (ii) intratopomer ordering: nonrandom, local conformational rearrangements within the native topomer to settle into the precise native state

Sonoluminescence: Two-photon correlations as a test of thermality

In this Letter we propose a fundamental test for probing the thermal nature of the spectrum emitted by sonoluminescence. We show that two-photon correlations can in principle discriminate between real thermal light and the quasi-thermal squeezed-state photons typical of models based on the dynamic Casimir effect. Two-photon correlations provide a powerful experimental test for various classes of sonoluminescence models.Comment: 6 pages, revtex 3; revised to include more discussion of finite volume effects; physics conclusions unchanged; to appear in Physics Letters

Falling for fake news: investigating the consumption of news via social media

In the so called ‘post-truth’ era, characterized by a loss of public trust in various institutions, and the rise of ‘fake news’ disseminated via the internet and social media, individuals may face uncertainty about the veracity of information available, whether it be satire or malicious hoax. We investigate attitudes to news delivered by social media, and subsequent verification strategies applied, or not applied, by individuals. A survey reveals that two thirds of respondents regularly consumed news via Facebook, and that one third had at some point come across fake news that they initially believed to be true. An analysis task involving news presented via Facebook reveals a diverse range of judgement forming strategies, with participants relying on personal judgements as to plausibility and scepticism around sources and journalistic style. This reflects a shift away from traditional methods of accessing the news, and highlights the difficulties in combating the spread of fake news

Sonoluminescence as a QED vacuum effect. II: Finite Volume Effects

In a companion paper [quant-ph/9904013] we have investigated several variations of Schwinger's proposed mechanism for sonoluminescence. We demonstrated that any realistic version of Schwinger's mechanism must depend on extremely rapid (femtosecond) changes in refractive index, and discussed ways in which this might be physically plausible. To keep that discussion tractable, the technical computations in that paper were limited to the case of a homogeneous dielectric medium. In this paper we investigate the additional complications introduced by finite-volume effects. The basic physical scenario remains the same, but we now deal with finite spherical bubbles, and so must decompose the electromagnetic field into Spherical Harmonics and Bessel functions. We demonstrate how to set up the formalism for calculating Bogolubov coefficients in the sudden approximation, and show that we qualitatively retain the results previously obtained using the homogeneous-dielectric (infinite volume) approximation.Comment: 23 pages, LaTeX 209, ReV-TeX 3.2, five figure

Sonoluminescence as a QED vacuum effect: Probing Schwinger's proposal

Several years ago Schwinger proposed a physical mechanism for sonoluminescence in terms of photon production due to changes in the properties of the quantum-electrodynamic (QED) vacuum arising from a collapsing dielectric bubble. This mechanism can be re-phrased in terms of the Casimir effect and has recently been the subject of considerable controversy. The present paper probes Schwinger's suggestion in detail: Using the sudden approximation we calculate Bogolubov coefficients relating the QED vacuum in the presence of the expanded bubble to that in the presence of the collapsed bubble. In this way we derive an estimate for the spectrum and total energy emitted. We verify that in the sudden approximation there is an efficient production of photons, and further that the main contribution to this dynamic Casimir effect comes from a volume term, as per Schwinger's original calculation. However, we also demonstrate that the timescales required to implement Schwinger's original suggestion are not physically relevant to sonoluminescence. Although Schwinger was correct in his assertion that changes in the zero-point energy lead to photon production, nevertheless his original model is not appropriate for sonoluminescence. In other works (see quant-ph/9805023, quant-ph/9904013, quant-ph/9904018, quant-ph/9905034) we have developed a variant of Schwinger's model that is compatible with the physically required timescales.Comment: 18 pages, ReV_TeX 3.2, 9 figures. Major revisions: This document is now limited to providing a probe of Schwinger's original suggestion for sonoluminescence. For details on our own variant of Schwinger's ideas see quant-ph/9805023, quant-ph/9904013, quant-ph/9904018, quant-ph/990503

Journalism as historical repair work: Addressing present injustice through the second draft of history

As part of contemporary racial reckoning, institutions are acknowledging their historical legacies of racism and discrimination. Media institutions, given their role in the social construction of reality, have been called to account by racial justice activists for perpetuating the white-dominant status quo. We develop a framework for recognizing and interpreting efforts at historical repair work in journalism, second draft of history journalism (SDOH), whereby contemporary consciousness about racial injustice, structural inequality, and exclusionary practices inside and outside journalism prompt news organizations to revisit the historical record. Through case study exemplars at U.S. newspapers, we define the three main modes—active, reflective, and active/reflective, and four key characteristics of SDOH journalism—discursive consciousness, institutional consciousness, moral consciousness, and past orientation. We address the contested boundaries of journalism’s cultural authority as journalists negotiate between SDOH journalism’s moral advocacy in pursuit of social justice and journalists’ professional journalistic norms of objectivity and neutrality

Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components

This minireview explores mitochondria as a site for antibiotic-host interactions that lead to pathophysiologic responses manifested as nonantibacterial side effects. Mitochondrion-based side effects are possibly related to the notion that these organelles are archaic bacterial ancestors or commandeered remnants that have co-evolved in eukaryotic cells; thus, this minireview focuses on mitochondrial damage that may be analogous to the antibacterial effects of the drugs. Special attention is devoted to aminoglycosides, chloramphenicol, and fluoroquinolones and their respective single side effects related to mitochondrial disturbances. Linezolid/oxazolidinone multisystemic toxicity is also discussed. Aminoglycosides and oxazolidinones are inhibitors of bacterial ribosomes, and some of their side effects appear to be based on direct inhibition of mitochondrial ribosomes. Chloramphenicol and fluoroquinolones target bacterial ribosomes and gyrases/topoisomerases, respectively, both of which are present in mitochondria. However, the side effects of chloramphenicol and the fluoroquinolones appear to be based on idiosyncratic damage to host mitochondria. Nonetheless, it appears that mitochondrion-associated side effects are a potential aspect of antibiotics whose targets are shared by prokaryotes and mitochondria—an important consideration for future drug design

Sonoluminescence as a QED vacuum effect. I: The Physical Scenario

Several years ago Schwinger proposed a physical mechanism for sonoluminescence in terms of changes in the properties of the quantum-electrodynamic (QED) vacuum state. This mechanism is most often phrased in terms of changes in the Casimir Energy: changes in the distribution of zero-point energies and has recently been the subject of considerable controversy. The present paper further develops this quantum-vacuum approach to sonoluminescence: We calculate Bogolubov coefficients relating the QED vacuum states in the presence of a homogeneous medium of changing dielectric constant. In this way we derive an estimate for the spectrum, number of photons, and total energy emitted. We emphasize the importance of rapid spatio-temporal changes in refractive indices, and the delicate sensitivity of the emitted radiation to the precise dependence of the refractive index as a function of wavenumber, pressure, temperature, and noble gas admixture. Although the physics of the dynamical Casimir effect is a universal phenomenon of QED, specific experimental features are encoded in the condensed matter physics controlling the details of the refractive index. This calculation places rather tight constraints on the possibility of using the dynamical Casimir effect as an explanation for sonoluminescence, and we are hopeful that this scenario will soon be amenable to direct experimental probes. In a companion paper we discuss the technical complications due to finite-size effects, but for reasons of clarity in this paper we confine attention to bulk effects.Comment: 25 pages, LaTeX 209, ReV-TeX 3.2, eight figures. Minor revisions: Typos fixed, references updated, minor changes in numerical estimates, minor changes in some figure