Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention

Multi-Coil MRI Reconstruction Challenge -- Assessing Brain MRI Reconstruction Models and their Generalizability to Varying Coil Configurations

Deep-learning-based brain magnetic resonance imaging (MRI) reconstruction methods have the potential to accelerate the MRI acquisition process. Nevertheless, the scientific community lacks appropriate benchmarks to assess MRI reconstruction quality of high-resolution brain images, and evaluate how these proposed algorithms will behave in the presence of small, but expected data distribution shifts. The Multi-Coil Magnetic Resonance Image (MC-MRI) Reconstruction Challenge provides a benchmark that aims at addressing these issues, using a large dataset of high-resolution, three-dimensional, T1-weighted MRI scans. The challenge has two primary goals: 1) to compare different MRI reconstruction models on this dataset and 2) to assess the generalizability of these models to data acquired with a different number of receiver coils. In this paper, we describe the challenge experimental design, and summarize the results of a set of baseline and state of the art brain MRI reconstruction models. We provide relevant comparative information on the current MRI reconstruction state-of-the-art and highlight the challenges of obtaining generalizable models that are required prior to broader clinical adoption. The MC-MRI benchmark data, evaluation code and current challenge leaderboard are publicly available. They provide an objective performance assessment for future developments in the field of brain MRI reconstruction

A Preliminary report on the legal code of Hermopolis West

Mattha Girgis. A Preliminary report on the legal code of Hermopolis West. In: Bulletin de l'Institut d'Egypte, tome 23, fascicule 2, 1940. pp. 297-312

Erleichterte Anweisung zur Erlernung des lateinischen Genus : zum Gebrauch der Schulen

von M. Gustav Friedrich Mattha, Conrector am Torgauischen LyceoVorlageform des Erscheinungsvermerks: Leipzig, bey Johann Gottfried Müller. 1779

Erleichterte Anweisung zur Erlernung des lateinischen Genus : zum Gebrauch der Schulen / von M. Gustav Friedrich Mattha, Conrector am Torgauischen Lyceo

Vorlageform des Erscheinungsvermerks: Leipzig, bey Johann Gottfried Müller. 1779

Bei dem Sarge des kleines Alexander Bützow: Wiburg d. 10 October 1821

Julkaisuvuosi nimekkeestä.Saksankielinen runo

Developing Technical Expertise to Support Synchronous Online Classes: The Columbia University School of Social Work Institute on Technical Skills for Online Event Production

Skilled technical support is essential to enable webinars, synchronous online classes, and other live online events to run smoothly.  Having a tech support professional dedicated to preventing and troubleshooting technology issues allows presenters to focus on the substance of online events. This article shares an example of an interactive online training program that develops the technical skills and expertise needed to support live online events hosted on web conferencing platforms.  The program, called the Institute on Technical Skills for Online Event Production, blends asynchronous homework and synchronous classes in an intensive, hands-on format.  Run by Columbia University School of Social Work’s Online Campus, this Institute trains social workers to become technical support specialists for online courses and events, and the approach is replicable across academic disciplines and for workplaces.</jats:p