MammoSapiens: eResearch of the lactation program. Building online facilities for collaborative molecular and evolutionary analysis of lactation and other biological systems from gene sequences and gene expression data.

Delivering bioinformatics power to life science researchers inevitably runs into problems of limited computing resources in the context of exponentially increasing data sources, access time, costs, lack of skills and, rapidly evolving technology and software tools with poorly defined standards. In this context the development of online facilities to best enable collaborative research often needs to be customized to specific project applications in close cooperation with the experimentalist users and, to be concerned with the storage and management of results to allow more consistency and traceability of results on a broad access data mining platform. Here we showcase an Internet based research platform using the PHP/MySQL paradigm for the collaborative, integrative and comparative analysis of lactation related gene sequences and gene expression experiments to support lactation research. We also illustrate how these resources are used, how they enable research by allowing meta-analysis of data and results and, how the bottom-up development of customized eResearch components can lead to the production of more generic functional software tools and eResearch environments for deployment to a larger number of biological researchers working on other bio-systems

A Survey of Needs for, and Availability of, Referral Sources for the Yucaipa Joint Unified School District Speech and Hearing Therapy Program

[Abstract Not Included

Validation of Continuous Conjugate Heat Transfer Model through Experimental Data

This research aims to examine the accuracy of a model used in density-based topology opti mization of conjugate heat transfer systems with an inherently porous solid, such as ceramics. The case study involves investigating fluid flow and heat transfer inside a tube with a mono lithic catalyst support internal. The validation includes simulating different flow rates (0.4, 0.7, 1.1 kg/h) in a non-reactive environment, utilizing identical honeycomb monolith geometry as reported in the experiments. This study addresses a significant gap in the existing literature: the lack of experimental validation for models relating to porous materials. The model’s valid ation against experimental data is essential in asserting its credibility and applicability in the dynamic field of topology optimization. The model predicts temperature distribution and pres sure drops, which are then compared with experimental data. Numerical simulations are con ducted using COMSOLVR Multiphysics for different flow rates, allowing for a comprehensive evaluation of the model. The findings reveal an acceptable discrepancy between simulated and experimental results, with an average relative error of 7.35% for pressure drops and 0.38% to 1.5% for temperature distributions, thereby demonstrating the accuracy of the model

A high-resolution mRNA expression time course of embryonic development in zebrafish.

We have produced an mRNA expression time course of zebrafish development across 18 time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos. Using poly(A) pulldown stranded RNA-seq and a 3' end transcript counting method we characterise temporal expression profiles of 23,642 genes. We identify temporal and functional transcript co-variance that associates 5024 unnamed genes with distinct developmental time points. Specifically, a class of over 100 previously uncharacterised zinc finger domain containing genes, located on the long arm of chromosome 4, is expressed in a sharp peak during zygotic genome activation. In addition, the data reveal new genes and transcripts, differential use of exons and previously unidentified 3' ends across development, new primary microRNAs and temporal divergence of gene paralogues generated in the teleost genome duplication. To make this dataset a useful baseline reference, the data can be browsed and downloaded at Expression Atlas and Ensembl

Der Krystall-Palast und Park zu Sydenham

DER KRYSTALL-PALAST UND PARK ZU SYDENHAM Der Krystall-Palast und Park zu Sydenham (-) Einband (-) Titelseite (-) Ansichten vom Kristallpalast und Park, Sydenham. ([1]) Beschreibung der Platten ([25]) Platte I: Inneres des pompeischen Hofes vom Eingang aus dem Schiff gesehen. ([25]) Platte II ([37]) Platte III: Der Palast von der Anerly-Station aus gesehen. ([39]) Platte IV: Ansicht des nörtlichen Chorschiffes. ([41]) Platte V: Der Ägyptische Hof, vom Schiff aus gesehen. ([45]) Platte VI: Der Assyrische Palast, restauriert von J. Fergusson, vom Schiff aus gesehen. ([49]) Platte VII: Ansicht des griechischen Hofes vom Schiff aus. ([53]) Platte VIII: Ansicht des römischen Hofes. ([55]) Platte IV: Der pompeische Hof. ([58]) Platte X: Der byzantinische Hof, vom Schiff aus gesehen. ([68]) Platte XI: Ansicht vom Innern des Alhambr Hofes. ([72]) Platte XII: Ansicht von dem Kreuzgang des ma. Hofes. ([78]) Platte XIII und Platte XIV: Ansichten von dem Äußerem und dem Inneren des Renaissance-Hofes. ([82]) Platte XV: Ansicht des Elisabethischen Hofes von dem Schiff aus. ([88]) Platte XVI: Ansicht des Italienischen Hofes. ([91]) Platte XVII: Ansicht des Italienischen Vestibüls. ([93]) Platte XVIII: Ansicht des Nördlichen Chorschiffes. ([95]) Platte XIX: Ansicht des Springbrunnens und Parks, von den Terassenstufen. ([98]) Platte XX: Ansicht eines Theils des Parks mit dem R[...]st[...]sentempel. ([100]) Platte XXI: Der Palast und die angrenzenden Ländereien vom Norden aus gesehen. ([105]) Platte XXII: Ansicht des großen Chorschiffs vom Rosarygarten aus. ([109]) Platte XXIII: Die untergegangenen Tiere restauriert von B. Waterhouse Hawkins. ([110]) Farbinformation (-) Einband (-

Lactation transcriptomics in the Australian marsupial, Macropus eugenii: transcript sequencing and quantification

<p>Abstract</p> <p>Background</p> <p>Lactation is an important aspect of mammalian biology and, amongst mammals, marsupials show one of the most complex lactation cycles. Marsupials, such as the tammar wallaby (<it>Macropus eugenii</it>) give birth to a relatively immature newborn and progressive changes in milk composition and milk production regulate early stage development of the young.</p> <p>Results</p> <p>In order to investigate gene expression in the marsupial mammary gland during lactation, a comprehensive set of cDNA libraries was derived from lactating tissues throughout the lactation cycle of the tammar wallaby. A total of 14,837 express sequence tags were produced by cDNA sequencing. Sequence analysis and sequence assembly were used to construct a comprehensive catalogue of mammary transcripts.</p> <p>Sequence data from pregnant and early or late lactating specific cDNA libraries and, data from early or late lactation massively parallel sequencing strategies were combined to analyse the variation of milk protein gene expression during the lactation cycle.</p> <p>Conclusion</p> <p>Results show a steady increase in expression of genes coding for secreted protein during the lactation cycle that is associated with high proportion of transcripts coding for milk proteins. In addition, genes involved in immune function, translation and energy or anabolic metabolism are expressed across the lactation cycle. A number of potential new milk proteins or mammary gland remodelling markers, including noncoding RNAs have been identified.</p

Views of the Crystal Palace and Park Sydenham

VIEWS OF THE CRYSTAL PALACE AND PARK SYDENHAM Views of the Crystal Palace and Park Sydenham (Tafel 24) Einband (-) The Pompeian Court (Tafel 1) list_of_illustrations (-) Engraved title-page (-) Titelseite (Tafel 24) Views of the Crystal Palace and Park, Sydenham ([7]) Describtion of the plates ([14]) The Pompeian Court (Tafel 1) General view from intermediate reservoir (Tafel 2) General view from Anerley Station (Tafel 3) View of Colossi in north transept (Tafel 4) The Egyptian court from the nave (Tafel 5) View of the exterior of the Assyrian Palace (Tafel 6) The Greek Court (Tafel 7) The Roman Court (Tafel 8) The Pompeian Court (Tafel 9) View of the Byzantine Court (Tafel 10) The Alhambra (Tafel 11) View in the Cloister of the Mediaeval Court (Tafel 12) The exterior of the Renaissance Court (Tafel 13) The interior of the Renaissance Court (Tafel 14) The Elizabethan Vestibule (Tafel 15) The Italian Court (Tafel 16) The Italian Vestibule (Tafel 17) View of north transept (Tafel 18) View of fountain and park from terrace steps (Tafel 19) View in park, showing cascade temple (Tafel 20) View of the palace and grounds from the north (Tafel 21) View from the Rosery (Tafel 22) The extinct animals (Tafel 23) Farbinformation (-) Einband (-

Towards an advanced 3D-printed catalyst for hydrogen peroxide decomposition: Development and characterisation

The propellant form of hydrogen peroxide is a non-toxic alternative to hydrazine. However, catalysts used to induce hydrogen peroxide decomposition are often plagued by low melting point, high pressure drop and poor activity. 3D-printing may offer solutions to many of these issues, through the realisation of complex geometries such as triply-periodic minimal surfaces (TPMS). In this work, methods to print and coat such ceramic catalyst supports were developed. A flow reactor was used to quickly screen the catalysts and assess the influence of the chosen active phase, precursor, and support sintering temperature on their intrinsic activity. Platinum prepared from H2PtCl6 emerged as the most active catalyst, with a support sintering temperature of 1200 °C yielding the highest BET surface area. The latter was strongly correlated to catalytic activity. On a per weight basis, the printed Pt catalyst outperformed conventional silver screens and also matched the performance of Pt on a high surface area commercial support, due to its egg-shell distribution. These findings have laid the groundwork for future testing in a thruster configuration, where the proposed advantages of the 3D-printed structures will be evaluated

Building Success in Online Educational Programs for Adult Learners

The purpose of this symposium is to explore multiple perspectives on building and maintaining high quality online educational programs in university settings for adult learners