Optimal Integrated Abundances for Chemical Tagging of Extragalactic Globular Clusters

High resolution integrated light (IL) spectroscopy provides detailed abundances of distant globular clusters whose stars cannot be resolved. Abundance comparisons with other systems (e.g. for chemical tagging) require understanding the systematic offsets that can occur between clusters, such as those due to uncertainties in the underlying stellar population. This paper analyses high resolution IL spectra of the Galactic globular clusters 47 Tuc, M3, M13, NGC 7006, and M15 to (1) quantify potential systematic uncertainties in Fe, Ca, Ti, Ni, Ba, and Eu and (2) identify the most stable abundance ratios that will be useful in future analyses of unresolved targets. When stellar populations are well-modelled, uncertainties are ~0.1-0.2 dex based on sensitivities to the atmospheric parameters alone; in the worst case scenarios, uncertainties can rise to 0.2-0.4 dex. The [Ca I/Fe I] ratio is identified as the optimal integrated [alpha/Fe] indicator (with offsets <0.1 dex), while [Ni I/Fe I] is also extremely stable to within <0.1 dex. The [Ba II/Eu II] ratios are also stable when the underlying populations are well modelled and may also be useful for chemical tagging.Comment: 28 pages, 4 figures, accepted for publication in the Monthly Notices of the Royal Astronomical Societ

A generalized no-broadcasting theorem

We prove a generalized version of the no-broadcasting theorem, applicable to essentially \emph{any} nonclassical finite-dimensional probabilistic model satisfying a no-signaling criterion, including ones with ``super-quantum'' correlations. A strengthened version of the quantum no-broadcasting theorem follows, and its proof is significantly simpler than existing proofs of the no-broadcasting theorem.Comment: 4 page

Coronary Artery Calcification (CAC) and Post-Trial Cardiovascular Events and Mortality Within the Women's Health Initiative (WHI) Estrogen-Alone Trial.

BackgroundAmong women aged 50 to 59 years at baseline in the Women's Health Initiative (WHI) Estrogen-Alone (E-Alone) trial, randomization to conjugated equine estrogen-alone versus placebo was associated with lower risk of myocardial infarction and mortality, and, in an ancillary study, the WHI-CACS (WHI Coronary Artery Calcification Study) with lower CAC, measured by cardiac computed tomography ≈8.7&nbsp;years after baseline randomization. We hypothesized that higher CAC would be related to post-trial coronary heart disease (CHD), cardiovascular disease (CVD), and total mortality, independent of baseline randomization or risk factors.Methods and resultsWHI-CACS participants (n=1020) were followed ≈8&nbsp;years from computed tomography scan in 2005 (mean age=64.4) through 2013 for incident CHD (myocardial infarction and fatal CHD, n=17), CVD (n=69), and total mortality (n=55). Incident CHD and CVD analyses excluded women with CVD before scan (n=89). Women with CAC=0 (n=54%) had very low age-adjusted rates/1000&nbsp;person-years of CHD (0.91), CVD (5.56), and mortality (3.45). In comparison, rates were ≈2-fold higher for women with any CAC (&gt;0). Associations were not modified by baseline randomization to conjugated equine estrogen-alone versus placebo. Adjusted for baseline randomization and risk factors, the hazard ratio (95% confidence interval) for CAC &gt;100 (19%) was 4.06 (2.11, 7.80) for CVD and 2.70 (1.26, 5.79) for mortality.ConclusionsAmong a subset of postmenopausal women aged 50 to 59 years at baseline in the WHI E-Alone Trial, CAC at mean age of 64 years was strongly related to incident CHD, CVD, and to total mortality over ≈8&nbsp;years, independent of baseline randomization to conjugated equine estrogen-alone versus placebo or CVD risk factors.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00000611

Divergent responses of Atlantic coastal and oceanic Synechococcus to iron limitation

Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of National Academy of Sciences for personal use, not for redistribution. The definitive version was published in Proceedings of the National Academy of Sciences of the United States of America 112 (2015): 9944-9949, doi:10.1073/pnas.1509448112.Marine Synechococcus are some of the most diverse and ubiquitous phytoplankton, and iron (Fe) is an essential micronutrient that limits productivity in many parts of the ocean. To investigate how coastal and oceanic Atlantic Synechococcus strains acclimate to Fe availability, we compared the growth, photophysiology, and quantitative proteomics of two Synechococcus strains from different Fe regimes. Synechococcus strain WH8102, from a region in the southern Sargasso Sea that receives substantial dust deposition, showed impaired growth and photophysiology as Fe declined, yet utilized few acclimation responses. Coastal WH8020, from the dynamic, seasonally variable New England shelf, displayed a multi-tiered, hierarchical cascade of acclimation responses with different Fe thresholds. The multi-tiered response included changes in Fe acquisition, storage, and photosynthetic proteins, substitution of flavodoxin for ferredoxin, and modified photophysiology, all while maintaining remarkably stable growth rates over a range of Fe concentrations. Modulation of two distinct ferric uptake regulator (Fur) proteins that coincided with the multi-tiered proteome response was found, implying the coastal strain has different regulatory threshold responses to low Fe availability. Low nitrogen (N) and phosphorus (P) availability in the open ocean may favor the loss of Fe response genes when Fe availability is consistent over time, whereas these genes are retained in dynamic environments where Fe availability fluctuates and N and P are more abundant.This work was supported by a National Science Foundation Postdoctoral Research Fellowship in Biology to K.R.M.M. (NSF 1103575), National Science Foundation Oceanography grants OCE-1220484, OCE-0928414, OCE-1233261, OCE- 1155566, OCE-1131387, and OCE-0926092, as well as Gordon and Betty Moore Foundation grants 3782 and 3934

Incorporating ecological and evolutionary processes into continental-scale conservation planning

Systematic conservation planning research has focused on designing systems of conservation areas that efficiently protect a comprehensive and representative set of species and habitats. Recently, there has been an emphasis on improving the adequacy of conservation area design to promote the persistence and future generation of biodiversity. Few studies have explored incorporating ecological and evolutionary processes into conservation planning assessments. Biodiversity in Australia is maintained and generated by numerous ecological and evolutionary processes at various spatial and temporal scales. We accommodated ecological and evolutionary processes in four ways: (1) using sub-catchments as planning units to facilitate the protection of the integrity and function of ecosystem processes occurring on a sub-catchment scale; (2) targeting one type of ecological refugia, drought refugia, which are critical for the persistence of many species during widespread drought; (3) targeting one type of evolutionary refugia which are important for maintaining and generating unique biota during long-term climatic changes; and (4) preferentially grouping priority areas along vegetated waterways to account for the importance of connected waterways and associated riparian areas in maintaining processes. We identified drought refugia, areas of relatively high and regular herbage production in arid and semiarid Australia, from estimates of gross primary productivity derived from satellite data. In this paper, we combined the novel incorporation of these processes with a more traditional framework of efficiently representing a comprehensive sample of biodiversity to identify spatial priorities across Australia. We explored the trade-offs between economic costs, representation targets, and connectivity. Priority areas that considered ecological and evolutionary processes were more connected along vegetated waterways and were identified for a small increase in economic cost. Priority areas for conservation investment are more likely to have long-term benefits to biodiversity if ecological and evolutionary processes are considered in their identification

Examining the Relationship between Medical Student Satisfaction and Academic Performance in a Pre-Clinical, Flipped-Classroom Curriculum

Medical schools are tasked with the responsibility of facilitating the acquisition of the specific vernacular, skill set, and reasoning capabilities of a physician for a group of individuals with a mélange of diverse experiences. Determining the best methods to train physicians is thus a challenge for those in medical education. Starting with the class of 2021, flipped classroom teaching and learning activities dominate Wright State University Boonshoft School of Medicine’s (WSU-BSOM) curriculum for MS1s and MS2s. This new curriculum is under constant evaluation to make sure it is best serving Boonshoft students. However, evaluating student evaluations on course satisfaction is difficult due to the amount of noise in qualitative data. We thus evaluated the quantitative and qualitative data from the surveys completed by the class of 2021 and correlated them with their NBME and final exam results from each module. It was found that a statistically significant relationship exists between student satisfaction and performance on final exams for most modules in this curriculum. Further studies are needed to create a framework for removing noise from these evaluations so those who design the curriculum may strive to improve student satisfaction in ways that will most improve student performance

When Bird and Fish Fall in Love

A work of poetry that offers a new method of poetics. By examining translation as a means of understanding relationships, this work offers a nuanced manner for the writing and experience of poetry. When Bird and Fish Fall in Love is a close examination of language, relationships, translation, and the intimacy of conflation

When Bird and Fish Fall in Love

A work of poetry that offers a new method of poetics. By examining translation as a means of understanding relationships, this work offers a nuanced manner for the writing and experience of poetry. When Bird and Fish Fall in Love is a close examination of language, relationships, translation, and the intimacy of conflation

Prehospital neurological deterioration in stroke

BACKGROUND AND PURPOSE: Patients with stroke can experience neurological deterioration in the prehospital setting. We evaluated patients with stroke to determine factors associated with prehospital neurological deterioration (PND). METHODS: Among the Greater Cincinnati/Northern Kentucky region (population ~1.3 million), we screened all 15 local hospitals' admissions from 2010 for acute stroke and included patients aged ≥20. The GCS was compared between emergency medical services (EMS) arrival and hospital arrival, with decrease ≥2 points considered PND. Data obtained retrospectively included demographics, medical history and medication use, stroke subtype (eg, ischaemic stroke (IS), intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH)) and IS subtype (eg, small vessel, large vessel, cardioembolic), seizure at onset, time intervals between symptom onset, EMS arrival and hospital arrival, EMS level of training, and blood pressure and serum glucose on EMS arrival. RESULTS: Of 2708 total patients who had a stroke, 1092 patients (median (IQR) age 74 (61-83) years; 56% women; 21% black) were analysed. PND occurred in 129 cases (12%), including 9% of IS, 24% of ICH and 16% of SAH. In multivariable analysis, black race, atrial fibrillation, haemorrhagic subtype and ALS level of transport were associated with PND. CONCLUSION: Haemorrhage and atrial fibrillation is associated with PND in stroke, and further investigation is needed to establish whether PND can be predicted. Further studies are also needed to assess whether preferential transport of patients with deterioration to hospitals equipped with higher levels of care is beneficial, identify why race is associated with deterioration and to test therapies targeting PND