Recommendations for minimizing green crud

The Array A-2 Green Crud problem, the investigation, and resulting recommendations were presented in ATM 1059 of 23 September 1971. With the occurrence of Green Crud in the Array E system in January, 1972 a second investigation of the means to prevent and/or remedy Green Crud was initiated. This ATM describes the results of this latter investigation.prepared by J. Matthis, D. K. Breseke

Sub-μ\mu structured Lotus Surfaces Manufacturing

Sub-micro structured surfaces allow modifying the behavior of polymer films or components. Especially in micro fluidics a lotus-like characteristic is requested for many applications. Structure details with a high aspect ratio are necessary to decouple the bottom and the top of the functional layer. Unlike to stochastic methods, patterning with a LIGA-mold insert it is possible to structure surfaces very uniformly or even with controlled variations (e.g. with gradients). In this paper we present the process chain to realize polymer sub-micro structures with minimum lateral feature size of 400 nm and up to 4 micrometers high.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838

Efficient C-Phase gate for single-spin qubits in quantum dots

Two-qubit interactions are at the heart of quantum information processing. For single-spin qubits in semiconductor quantum dots, the exchange gate has always been considered the natural two-qubit gate. The recent integration of magnetic field or g-factor gradients in coupled quantum dot systems allows for a one-step, robust realization of the controlled phase (C-Phase) gate instead. We analyze the C-Phase gate durations and fidelities that can be obtained under realistic conditions, including the effects of charge and nuclear field fluctuations, and find gate error probabilities of below 10-4, possibly allowing fault-tolerant quantum computation.Comment: 5 pages, 3 figure

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway

Peer reviewedPublisher PD

Proteolytic Processing of OPA1 Links Mitochondrial Dysfunction to Alterations in Mitochondrial Morphology

Many muscular and neurological disorders are associated with mitochondrial dysfunction and are often accompanied by changes in mitochondrial morphology. Mutations in the gene encoding OPA1, a protein required for fusion of mitochondria, are associated with hereditary autosomal dominant optic atrophy type I. Here we show that mitochondrial fragmentation correlates with processing of large isoforms of OPA1 in cybrid cells from a patient with myoclonus epilepsy and ragged-red fibers syndrome and in mouse embryonic fibroblasts harboring an error-prone mitochondrial mtDNA polymerase {gamma}. Furthermore, processed OPA1 was observed in heart tissue derived from heart-specific TFAM knock-out mice suffering from mitochondrial cardiomyopathy and in skeletal muscles from patients suffering from mitochondrial myopathies such as myopathy encephalopathy lactic acidosis and stroke-like episodes. Dissipation of the mitochondrial membrane potential leads to fast induction of proteolytic processing of OPA1 and concomitant fragmentation of mitochondria. Recovery of mitochondrial fusion depended on protein synthesis and was accompanied by resynthesis of large isoforms of OPA1. Fragmentation of mitochondria was prevented by overexpressing OPA1. Taken together, our data indicate that proteolytic processing of OPA1 has a key role in inducing fragmentation of energetically compromised mitochondria. We present the hypothesis that this pathway regulates mitochondrial morphology and serves as an early response to prevent fusion of dysfunctional mitochondria with the functional mitochondrial network

Direct observation of t2g orbital ordering in magnetite

Using soft-x-ray diffraction at the site-specific resonances in the Fe L23 edge, we find clear evidence for orbital and charge ordering in magnetite below the Verwey transition. The spectra show directly that the (001/2) diffraction peak (in cubic notation) is caused by t2g orbital ordering at octahedral Fe2+ sites and the (001) by a spatial modulation of the t2g occupation.Comment: to appear in Phys. Rev. Let

High-frequency earth rotation variations deduced from altimetry-based ocean tides

A model of diurnal and semi-diurnal variations in Earth rotation parameters (ERP) is constructed based on altimetry-measured tidal heights from a multi-mission empirical ocean tide solution. Barotropic currents contributing to relative angular momentum changes are estimated for nine major tides in a global inversion algorithm that solves the two-dimensional momentum equations on a regular 0.5^\circ grid with a heavily weighted continuity constraint. The influence of 19 minor tides is accounted for by linear admittance interpolation of ocean tidal angular momentum, although the assumption of smooth admittance variations with frequency appears to be a doubtful concept for semi-diurnal mass terms in particular. A validation of the newly derived model based on post-fit corrections to polar motion and universal time (\Delta UT1) from the analysis of Very Long Baseline Interferometry (VLBI) observations shows a variance reduction for semi-diurnal \Delta UT1 residuals that is significant at the 0.05 level with respect to the conventional ERP model. Improvements are also evident for the explicitly modeled K_1, Q_1, and K_2 tides in individual ERP components, but large residuals of more than 15 \upmu as remain at the principal lunar frequencies of O_1 and M_2. We attribute these shortcomings to uncertainties in the inverted relative angular momentum changes and, to a minor extent, to violation of mass conservation in the empirical ocean tide solution. Further dedicated hydrodynamic modeling efforts of these anomalous constituents are required to meet the accuracy standards of modern space geodesy

Onderzoeksrapport CREM

In het rapport dat voor u ligt zullen de resultaten te vinden zijn van het onderzoek naar de invulling van Corporate Real Estate Management van verschillende bedrijven. De aanleiding van dit onderzoek is, het verkrijgen van meer kennis op het gebied van CREM zodat een verdere professionalisering mogelijk is. Om de juiste informatie te krijgen is de volgende onderzoeksvraag geformuleerd:‘Op welke manier wordt CREM door een aantal koplopers in dit vakgebied inhoudelijk en organisatorisch ingevuld en welke factoren, gerelateerd aan kenmerken van de organisatie en de vastgoedportefeuille, kunnen helpen de onderlinge verschillen te verklaren?’ Deze onderzoeksvraag is te veel omvattend en daarom is hij onderverdeelt in drie deelvragen: 1. Wat is de aard en de omvang van de betreffende organisatie? (organisatieprofiel?) 2. Wat is de aard en de omvang van de vastgoedportefeuille van het betreffende bedrijf? (portefeuilleprofiel?) 3. Wat is de wijze waarop CREM inhoudelijk en organisatorisch is ingevuld bij het betreffende bedrijf? (CREM-profiel) In het rapport zullen verschillende aspecten aanbod komen. In hoofdstuk twee wordt achtergrondinformatie gegeven over het onderwerp. Vervolgens wordt in hoofdstuk drie het probleem geformuleerd. Daarna zal in hoofdstuk vier onderzoeksmethode worden toegelicht. Vervolgens staan de resultaten van het onderzoek in hoofdstuk vijf. In hoofdstuk zes wordt vervolgens een interpretatie gegeven van de onderzoeksresultaten. In hoofdstuk zeven wordt er een conclusie gevormd. Tot slot zal in hoofdstuk acht aanbevelingen worden gedaan voor eventueel vervolgonderzoek. Studentenonderzoek in het kader van het thema Leefomgeving