Presence of depressive symptoms in patients with a first episode of acute Coronary Syndrome

AIM: to compare possible differences regarding the presence of depressive symptoms according to the clinical diagnosis of Acute Coronary Syndrome, gender and age, one week before the first cardiac event. METHOD: cross-sectional, descriptive and exploratory study, which used the Beck Depression Inventory. The sample consisted of 253 patients. RESULTS: it was found that patients with a clinical diagnosis of unstable angina, female and under 60 years of age reported the presence of depressive symptoms more frequently. CONCLUSION: a high percentage of patients presented depressive symptoms at the time of hospitalization for the first episode of Acute Coronary Syndrome, and this prevalence was significantly higher among women, under 60 years of age, with unstable angina. These results should provide support for the care in the hospitalization, discharge and planning of the rehabilitation of these patients, as it is known that depression impairs the control of coronary disease

The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence

Trost E, Ott L, Schneider J, et al. The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence. BMC Genomics. 2010;11(1): 728

Cost-benefit of hospitalization compared with outpatient care for pregnant women with pregestational and gestational diabetes or with mild hyperglycemia, in Brazil

CONTEXTO E OBJETIVO: Gestações complicadas pelo diabetes estão associadas com aumento de complicações maternas e neonatais. Os custos hospitalares aumentam de acordo com a assistência prestada. O objetivo foi calcular o custo-benefício e a taxa de rentabilidade social da hospitalização comparada ao atendimento ambulatorial em gestantes com diabetes ou com hiperglicemia leve. DESENHO do ESTUDO: Estudo prospectivo, observacional, quantitativo, realizado em hospital universitário, sendo incluídas todas as gestantes com diabetes pregestacional e gestacional ou com hiperglicemia leve que não desenvolveram intercorrências clínicas na gestação e que tiveram parto no Hospital das Clínicas, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (HC-FMB-Unesp). MÉTODOS: Trinta gestantes tratadas com dieta foram acompanhadas em ambulatório e 20 tratadas com dieta e insulina foram abordadas com hospitalizações curtas e frequentes. Foram obtidos custos diretos (pessoal, material e exames) e indiretos (despesas gerais) a partir de dados contidos no prontuário e no sistema de custo por absorção do hospital e posteriormente calculado o custo-benefício. RESULTADOS: O sucesso do tratamento das gestantes diabéticas evitou o gasto de US$1.517,97 e US$ 1.127,43 para pacientes hospitalizadas e ambulatoriais, respectivamente. O custo-benefício da atenção hospitalizada foi US$143.719,16 e ambulatorial, US$ 253.267,22, com rentabilidade social 1,87 e 5,35 respectivamente. CONCLUSÃO: A análise árvore de decisão confirma que o sucesso dos tratamentos elimina custos no hospital. A relação custo-benefício indicou que o tratamento ambulatorial é economicamente mais vantajoso do que a hospitalização. A rentabilidade social de ambos os tratamentos foi maior que 1, indicando que ambos os tipos de atendimento à gestante diabética têm benefício positivo.CONTEXT and OBJECTIVE: Pregnancies complicated by diabetes are associated with increased numbers of maternal and neonatal complications. Hospital costs increase according to the type of care provided. This study aimed to estimate the cost-benefit relationship and social profitability ratio of hospitalization, compared with outpatient care, for pregnant women with diabetes or mild hyperglycemia. STUDY DESIGN: This was a prospective observational quantitative study conducted at a university hospital. It included all pregnant women with pregestational or gestational diabetes, or mild hyperglycemia, who did not develop clinical intercurrences during pregnancy and who delivered at the Botucatu Medical School Hospital (Hospital das Clínicas, Faculdade de Medicina de Botucatu, HC-FMB) of Universidade Estadual de São Paulo (Unesp). METHODS: Thirty pregnant women treated with diet were followed as outpatients, and twenty treated with diet plus insulin were managed through frequent short hospitalizations. Direct costs (personnel, materials and tests) and indirect costs (general expenses) were ascertained from data in the patients' records and the hospital's absorption costing system. The cost-benefit was then calculated. RESULTS: Successful treatment of pregnant women with diabetes avoided expenditure of US$1,517.97 and US$ 1,127.43 for patients treated with inpatient and outpatient care, respectively. The cost-benefit of inpatient care was US$143,719.16, and outpatient care, US$ 253,267.22, with social profitability of 1.87 and 5.35, respectively. CONCLUSION: Decision-tree analysis confirmed that successful treatment avoided costs at the hospital. Cost-benefit analysis showed that outpatient management was economically more advantageous than hospitalization. The social profitability of both treatments was greater than one, thus demonstrating that both types of care for diabetic pregnant women had positive benefits.Univ Estadual Paulista Unesp, FMB, HC, Dept Gynecol & Obstet, Botucatu, SP, BrazilUniv Estadual Paulista Unesp, FMB, HC, Dept Nursing, Botucatu, SP, BrazilUniv Estadual Paulista Unesp, Postgrad Programs, Botucatu, SP, BrazilUniv Estadual Paulista Unesp, FMB, HC, Dept Gynecol & Obstet, Botucatu, SP, Brazi

Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures

Data availability: Raw data are available upon reasonable request pending appropriate study approvals and data transfer agreements between participating institutions. Interested researchers should contact Emily Dennis ([email protected]). Code used for analysis and online tool creation are available upon request.Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. These efforts unveil new questions about how to integrate data across distinct sources and instruments. The goal of this study was to link scores across common auditory verbal learning tasks (AVLTs). This international secondary analysis aggregated multisite raw data for AVLTs across 53 studies totaling 10,505 individuals. Using the ComBat-GAM algorithm, we isolated and removed the component of memory scores associated with site effects while preserving instrumental effects. After adjustment, a continuous item response theory model used multiple memory items of varying difficulty to estimate each individual’s latent verbal learning ability on a single scale. Equivalent raw scores across AVLTs were then found by linking individuals through the ability scale. Harmonization reduced total cross-site score variance by 37% while preserving meaningful memory effects. Age had the largest impact on scores overall (− 11.4%), while race/ethnicity variable was not significant (p > 0.05). The resulting tools were validated on dually administered tests. The conversion tool is available online so researchers and clinicians can convert memory scores across instruments. This work demonstrates that global harmonization initiatives can address reproducibility challenges across the behavioral sciences.Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III: PI15-00852, PI18-00945, JR19-00024, PI17-00481, PI20-00721, Sara Borrell contract (CD19-00149); European Union: NextGenerationEU (PMP21/00051), PI19/01024, Structural Funds, Seventh Framework Program, H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2 (Grant agreement No.101034377), Project AIMS-2-TRIALS (Grant agreement No 777394), Horizon Europe; National Institutes of Health: U01MH124639, P50MH115846, R01MH113827, R25MH080663, K08MH068540, R01NS100973, R01EB006841, P20GM103472, RO1MH083553, T32MH019535, R01 HD061504, RO1MH083553, R01AG050595, R01AG076838, R01AG060470, R01AG064955, P01AG055367, K23MH095661, R01MH094524, R01MH121246, T32MH019535, R01NS124585, R01NS122827, R61NS120249, R01NS122184, U54EB020403, R01MH116147, R56AG058854, P41EB015922, R01MH111671, P41RR14075, M01RR01066, R01EB006841, R01EB005846, R01 EB000840, RC1MH089257, U24 RR021992, NCRR 5 month-RR001066 (MGH General Clinical Research Center); NSF: 2112455; Madrid Regional Government: B2017/BMD-3740 AGES-CM-2; Dalhousie Medical Research Foundation; Research Nova Scotia, RNS-NHIG-2021-1931; US Department of Defense: Award # AZ150145; US Department of Veterans Affairs: 1I01RX003444; NJ Commission on TBI Research Grants: CBIR11PJT020, CBIR13IRG026: Department of Psychology, University of Oslo; Sunnaas Rehabilitation Hospital: HF F32NS119285; Canadian Institutes of Health Research: Grant 166098; Neurological Foundation of New Zealand; Canterbury Medical Research Foundation, University of Otago. Biogen US, Investigator-initiated grant; Italian Ministry of Health: RF-2019-12370182, Ricerca Corrente RC 23; National Institute on Aging: National Health and Medical Research Council, Investigator Grant APP1176426; PA Health Research: Grant SAP #4100077082 to Dr. Hillary; La Caixa Foundation, ID: 100010434, fellowship code: LCF/BQ/PR22/11920017; Research Council of Norway: 248238; Health Research Council of New Zealand: Sir Charles Hercus Early Career Development (17/039), 14-440; South-Eastern Norway Regional Health Authority, 2018076; Norwegian ExtraFoundation for Health and Rehabilitation: 2015/ FO5146, 2015044; Stiftelsen K.G. Jebsen, SKGJ MED-02; German Research Foundation: DFG grant FOR2107 to Andreas Jansen, JA 1890/7-1, JA 1890/7-2, DFG grant FOR2107 to Igor Nenadić, NE2254/1-2,NE2254/3-1,NE2254/4-1, DFG grant FOR2107, KI588/14-1 and FOR2107, KI588/14-2, DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2, SFB-TRR58, Projects C09 and Z02; Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU); National Health and Medical Research Council: APP1020526; Brain Foundation, Wicking Trust, Collie Trust, Sidney and Fiona Myer Family Foundation. U.S. Army Medical Research and Materiel Command (USAMRMC): Award #13129004; Department of Energy: DE- FG02-99ER62764: Mind Research Network, National Association for Research in Schizophrenia and Affective Disorders: Young Investigator Award, Blowitz Ridgeway and Essel Foundations, NOW ZonMw TOP 91211021, UCLA Easton Clinic for Brain Health, UCLA Brain Injury Research Center, Stan and Patty Silver, Clinical and Translational Research Center: UL1RR033176, UL1TR000124; Mount Sinai Institute for NeuroAIDS Disparities, VA Rehab SPIRE, CDMRP PRAP, VA RR&D IK2RX002922, Veski Fellowship, Femino Foundation grant, Fundación Familia Alonso, Fundación Alicia Koplowitz, CIBERSAM, Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), 2019R1C1C1002457, 21-BR-03-01, 2020M3E5D9079910, 21-BR-03-01, Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Münster

Analyses of biofilms accumulated on dental restorative materials

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Purpose: To qualitatively and quantitatively assess the architectural arrangement of microorganisms in biofilm developed on the surface of different restorative materials: ceramic (C), resin composite (RC), conventional (CGIC) and resin-modified glass-ionomer cements (RMGIC). Methods: Streptococcus mutans was used to develop a biofilm that adhered to the surfaces of the selected material disks in 30 days. The specimens were stained and analyzed by confocal laser scanning microscopy and COMSTAT. Among biofilm properties, mean thickness, total bio-volume, roughness coefficient and surface-to-volume ratio were investigated, as well as characteristics of the distribution and architecture of viable/nonviable cells in the biofilm. Results: Only the mean biofilm thickness was statistically significantly different among the restorative materials tested. C and RC accumulated the thickest biofilms. Qualitative analysis showed cellular aggregates and fluid-filled channels penetrating to a considerable depth of the biofilm. In addition, images demonstrated a progression of more viable cells in superficial regions of the biofilm to proportionally more nonviable cells in the deeper regions of the biofilms near the disk. (Am J Dent 2009;22:131-136).223131136Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES