Energiesprong - Betrachtung des ganzheitlichen Konzepts für serielles Sanieren unter den Rahmenbedingungen von Mehrfamilienhäusern

Energiesprong (niederländisch für Energiesprung) ist ein innovatives Konzept für die energetische Sanierung von Wohngebäuden, das schnelle Umsetzung, Kostenreduktion, Nachhaltigkeit und Mieterfreundlichkeit verspricht. Energiesprong setzt auf industrielle Vorfertigung von Fassaden- und Dachelementen (serielle Sanierung) und den Einsatz von regenerativen Energien, um den sogenannten NetZero-Standard (entspricht dem Nullenergiehaus) zu erreichen. Ziel ist es, eine für alle Beteiligten attraktive Sanierung zu ermöglichen. Dies wird unter anderem über erheblich verkürzte Montagezeiten und warmmietenneutrale Refinanzierung angestrebt. Die dafür erforderlichen Kostensenkungen werden beim seriellen Sanieren durch die Automatisierung in der Produktion und Skaleneffekte in der Massenfertigung erreicht. Im Rahmen dieser Arbeit soll das Konzept Energiesprong hinsichtlich der Anwendung auf Mehrfamilienhäuser betrachtet und kritisch hinterfragt werden. Dazu werden zuvorderst die politischen und praktischen Gründe umrissen, die die Notwendigkeit und das Potenzial von innovativen Ansätzen darstellen. Im zweiten Kapitel wird das Energiesprong-Konzept detailliert erläutert; neben den Innovationen im Plan und Bauverfahren werden die Besonderheiten der Gebäudehülle, der Anlagentechnik und des Energiekonzepts beschrieben. Darüber hinaus werden wirtschaftliche Aspekte und die Rolle der verschiedenen Akteure umrissen. Aus der Beschreibung gehen eine Vielzahl an Vorteilen hervor, die Energiesprong gegenüber konventionellen Sanierungsverfahren verspricht. Anschließend werden einige Punkte dieser zentralen Versprechen diskutiert und eine Grundlage für die Entwicklung von Kriterien zukünftiger Evaluationen entwickelt

Enabling Industry 4.0: A Roadmap for Efficient Implementation of 5G Campus Networks in Manufacturing

Private 5G networks, which are localized and designed for specific organizations or facilities, enable industrial production environments to transform by providing unparalleled opportunities for enhanced operational efficiency, flexibility, and digital connectivity. Based on four expert interviews and a detailed literature review for further validation, this paper presents a holistic roadmap for implementing private 5G networks in production settings. This roadmap adopts a phased approach, beginning with awareness and needs assessment, followed by the development of specific technical concepts, pilot implementation, network scalability, and ongoing optimization. Each phase is designed to address unique challenges and critical decisions involved in the successful deployment of 5G, including use case identification (e.g., predictive maintenance and autonomous systems), network architecture, partnership models, and integration with legacy IT infrastructure. This guided approach provides production facilities a pragmatic framework to navigate the technical, organizational, and economic complexities of 5G implementation, ensuring alignment with industry requirements and future technological developments. The proposed roadmap synthesizes insights from subject matter experts and recent literature, providing a sustainable, adaptable, and resilient strategy for 5G network deployment in production environments

Agrivoltaics in Germany - Status Quo and Future Developments: Evaluation of the German Agrivoltaics Innovation Tender 2022 and Overview about the Agrivoltaics Development in Germany

Ground-mounted photovoltaic facilities in open spaces have been common in Germany for many years. However, according to the legislation, these are only supported by the government on poorer quality soils, former military training areas, or along traffic routes. Nevertheless, also on high quality soils it is not forbidden to install ground-mounted photovoltaic facilities. In recent years, Germany has started implementing agrivoltaics, which is an alternative land use concept that combines agriculture and renewable energy production. This opens the possibility to use land of higher soil quality for energy generation without necessarily creating land-use conflicts and being subsidized by the government. This study aims to provide a comprehensive overview of existing and planned agrivoltaic facilities in Germany analyzing them based on various parameters. The data for this study was collected through a community questionnaire and supplemented with data from state institutions. The results indicate that as of March 2023, 21 agrivoltaic facilities with a total capacity of 81.67 MWp have been installed. A strong increase of the installed capacity is expected in 2023 and 2024, reaching approximately 382.59 MWP by the end of 2024. The market development of agrivoltaics is mainly driven by changes in the legal environment which present opportunities for further market ramp-up of agrivoltaics. The adoption of agrivoltaics shows a notable spatial diversity in Germany which appears to be influenced by the interaction between regulatory environments and agricultural structures

Exophiala angulospora infection in hatchery reared lumpfish (Cyclopterus lumpus) broodstock

Funding Information Biotechnology and Biological Sciences Research Council. Grant Numbers: BB/M026566/1, BB/P020224/1 Natural Environment Research Council. Grant Number: NE/P007570/1 University of AberdeenPeer reviewedPublisher PD

Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics

Despite recent experimental and clinical progress in the treatment of tibial and fibular fractures, in clinical practice rates of delayed bone healing and non-union remain high. The aim of this study was to simulate and compare different mechanical conditions after lower leg fractures to assess the effects of postoperative motion, weight-bearing restrictions and fibular mechanics on the strain distribution and the clinical course. Based on the computed tomography (CT) data set of a real clinical case with a distal diaphyseal tibial fracture, a proximal and a distal fibular fracture, finite element simulations were run. Early postoperative motion data, recorded via an inertial measuring unit system and pressure insoles were recorded and processed to study strain. The simulations were used to compute interfragmentary strain and the von Mises stress distribution of the intramedullary nail for different treatments of the fibula, as well as several walking velocities (1.0 km/h; 1.5 km/h; 2.0 km/h) and levels of weight-bearing restriction. The simulation of the real treatment was compared to the clinical course. The results show that a high postoperative walking speed was associated with higher loads in the fracture zone. In addition, a larger number of areas in the fracture gap with forces that exceeded beneficial mechanical properties longer was observed. Moreover, the simulations showed that surgical treatment of the distal fibular fracture had an impact on the healing course, whereas the proximal fibular fracture barely mattered. Weight-bearing restrictions were beneficial in reducing excessive mechanical conditions, while it is known that it is difficult for patients to adhere to partial weight-bearing recommendations. In conclusion, it is likely that motion, weight bearing and fibular mechanics influence the biomechanical milieu in the fracture gap. Simulations may improve decisions on the choice and location of surgical implants, as well as give recommendations for loading in the postoperative course of the individual patient

Investigation of the Crack Behavior of CRC Using 4D Computed Tomography, Photogrammetry, and Fiber Optic Sensing

The highly irregular crack pattern of reinforced concrete has been studied primarily at the surface. The ability to extend image correlation into the interior of structures by using X-ray computed tomography (CT) opens up new possibilities for analyzing the internal mechanics of concrete. In order to enable a complete material characterization, it is necessary to study the crack geometry at the micro level in 3D images over time, i.e., 4D data. This paper presents the results of in situ CT tests that were carried out on carbon-reinforced concrete (CRC) beams subjected to bending load. The main objective of the tests was the experimental analysis of the evolution of individual cracks at different stages of their formation by applying digital volume correlation (DVC) to the 4D image data from the computed tomography. The results obtained from the CT were compared with other measurement techniques, such as distributed fiber optic sensing, clip gauges, and digital image correlation (DIC)

Clinical Relevance of Transjugular Liver Biopsy in Comparison with Percutaneous and Laparoscopic Liver Biopsy

Background. Transjugular liver biopsy (TJLB) is frequently used to obtain liver specimens in high-risk patients. However, TJLB sample size possibly limits their clinical relevance. Methods. 102 patients that underwent TJLB were included. Clinical parameters and outcome of TJLB were analyzed. Control samples consisted of 112 minilaparoscopic liver biopsies (mLLBs) and 100 percutaneous liver biopsies (PLBs). Results. Fewer portal tracts were detected in TJLB (4.3 ± 0.3) in comparison with PLB (11.7 ± 0.5) and mLLB (11.0 ± 0.6). No difference regarding the specification of indeterminate liver disease and staging/grading of chronic hepatitis was observed. In acute liver failure (n = 32), a proportion of hepatocellular necrosis beyond 25% was associated with a higher rate of death or liver transplantation. Conclusions. Despite smaller biopsy samples the impact on the clinical decision process was found to be comparable to PLB and mLLB. TJLB represents a helpful tool to determine hepatocellular necrosis rates in patients with acute liver failure

Economic Transition and Natural Resource Management in East-and Southeast Asia

Abstract: For several decades the effective and efficient dissemination of new agricultural knowledge among farmers in developing countries has been problematic. Two major programs were implemented in Indonesia, namely The Training and Visit (T&V) Extension Program or The Massive Guidance (BIMAS) Program, from the mid 1960s until the end of the1980s, and the Farmer Field School (FFS) Program, during the 1990s. The main difference between these two programs is that, where the T&V was concerned, farmers were instructed what to do, while the FFS program encouraged and stimulated farmers to make their own decisions. This paper aims to discuss and compare the effectiveness of these two programs with reference to rice production in Indonesia. This paper would like to argue that, for regions where the level of development is still very low, implementing a T&V program instructing farmers what to do is probably more appropriate than an FFS. As for regions where agriculture is relatively developed, an effective FFS program is more appropriate

The WERA cancer center matrix: strategic management of patient access to precision oncology in a large and mostly rural area of Germany

Purpose Providing Patient Access to Precision Oncology (PO) is a major challenge of clinical oncologists. Here, we provide an easily transferable model from strategic management science to assess the outreach of a cancer center. Methods As members of the German WERA alliance, the cancer centers in Würzburg, Erlangen, Regensburg and Augsburg merged care data regarding their geographical impact. Specifically, we examined the provenance of patients from WERA´s molecular tumor boards (MTBs) between 2020 and 2022 (n = 2,243). As second dimension, we added the provenance of patients receiving general cancer care by WERA. Clustering our catchment area along these two dimensions set up a four-quadrant matrix consisting of postal code areas with referrals towards WERA. These areas were re-identified on a map of the Federal State of Bavaria. Results The WERA Matrix overlooked an active screening area of 821 postal code areas – representing about 50% of Bavaria´s spatial expansion and more than six million inhabitants. The WERA Matrix identified regions successfully connected to our outreach structures in terms of subsidiarity – with general cancer care mainly performed locally but PO performed in collaboration with WERA. We also detected postal code areas with a potential PO backlog – characterized by high levels of cancer care performed by WERA and low levels or no MTB representation. Conclusions The WERA Matrix provided a transparent portfolio of postal code areas, which helped assessing the geographical impact of our PO program. We believe that its intuitive principle can easily be transferred to other cancer centers

Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers

BACKGROUND: Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS: To assess the frequencies and clinical impact of amplifications, we analyzed 547 invasive breast tumors organized in a tissue microarray (TMA) by fluorescence in situ hybridization (FISH) and calculated correlations with histoclinical features and prognosis. BAC probes were designed for: (i) two 8p12 subregions centered on RAB11FIP1 and FGFR1 loci, respectively; (ii) 11q13 region centered on CCND1; (iii) 12p13 region spanning NOL1; and (iv) three 20q13 subregions centered on MYBL2, ZNF217 and AURKA, respectively. Regions 8q24 and 17q12 were analyzed with MYC and ERBB2 commercial probes, respectively. RESULTS: We observed amplification of 8p12 (amplified at RAB11FIP1 and/or FGFR1) in 22.8%, 8q24 in 6.1%, 11q13 in 19.6%, 12p13 in 4.1%, 17q12 in 9.9%, 20q13(Z )(amplified at ZNF217 only) in 9.9%, and 20q13(Co )(co-amplification of two or three 20q13 loci) in 8.5% of cases. The 8q24, 12p13, and 17q12 amplifications were correlated with high grade. The most frequent single amplifications were 8p12 (9.8%), 8q24 (3.3%) and 12p13 (3.3%), 20q13(Z )and 20q13(Co )(1.6%) regions. The 17q12 and 11q13 regions were never found amplified alone. The most frequent co-amplification was 8p12/11q13. Amplifications of 8p12 and 17q12 were associated with poor outcome. Amplification of 12p13 was associated with basal molecular subtype. CONCLUSION: Our results establish the frequencies, prognostic impacts and subtype associations of various amplifications and co-amplifications in breast cancers